DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Uba1 and Uba1y

DIOPT Version :9

Sequence 1:	NP_477310.2	Gene:	Uba1 / 35998	FlyBaseID:	FBgn0023143	Length:	1191	Species:	Drosophila melanogaster
Sequence 2:	XP_008771907.1	Gene:	Uba1y / 25225	RGDID:	3925	Length:	1057	Species:	Rattus norvegicus

Alignment Length:	1066	Identity:	606/1066 - (56%)
Similarity:	770/1066 - (72%)	Gaps:	31/1066 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly   145 SQEASSSASATSNSNNNVSSSNNNSNNSTNNRQLEGSSNMAGNSAAAGGDIDESLYSRQLYVLGH 209
            |....|.....|..::.|.||..::::.........:|.|:.|...   ||||||||||||||||
  Rat     2 SSSVLSKKRRVSGPDSEVDSSWPSTHSVMFGAPPGPNSGMSKNKEM---DIDESLYSRQLYVLGH 63

  Fly   210 DAMRRMANSDILLSGLGGLGLEIAKNVILGGVKSITLHDTATCGLHDLSSQFYLTEADIGKNRAE 274
            :||:.:..|.:|:|||.|||:|||||:||||||::||||..|....||||||||.|.||||||||
  Rat    64 EAMKHLQTSSVLISGLQGLGVEIAKNIILGGVKAVTLHDQGTAQWADLSSQFYLHEEDIGKNRAE 128

  Fly   275 ASCAQLAELNNYVRTVSHTGPLTEEFLRKFRVVVLTNSDGEEQQRIAKFAHENGIALIIAETRGL 339
            .|..:|||||:||...::||||.::||..|:||||||:..|.|.::.:|.|.:||.|::|:||||
  Rat   129 VSQPRLAELNSYVPVHTYTGPLVDDFLSGFQVVVLTNTPLEYQLQVGEFCHSHGIKLVVADTRGL 193

  Fly   340 FAKVFCDFGESFTIYDQDGTQPISTMIASITHDAQGVVTCLDETRHGFNDGDYVTFSEVQGMQEL 404
            ..::||||||...:.|.:|.||:|.|::.||.:..|:||||:||||||..||:|:|:|||||.||
  Rat   194 VGQLFCDFGEEMILTDANGEQPLSAMVSMITKENPGIVTCLEETRHGFESGDFVSFTEVQGMSEL 258

  Fly   405 NGCQPLKITVLGPYTFSIGDTSKFGEYKSGGVATQVKMPKTISFKPLAQATEEPEFLISDFAKLD 469
            ||..|::|.|||||:|||.|||.|.||..||:.:|||:.:.||||.|..:..||||:|:||||..
  Rat   259 NGIGPMEIKVLGPYSFSICDTSSFSEYTRGGIVSQVKVSQKISFKSLVASLAEPEFVITDFAKCC 323

  Fly   470 SPATLHVAFNALSCYRKAHNGALPRPWNEEDANSFLEVVRASSNAE---------VDEKLVLQFA 525
            .||.||:.|.||..:...|:.. |||.|||||...:.:.:| .||:         :|..|:.:.|
  Rat   324 RPAQLHIGFQALHQFCTQHSRP-PRPHNEEDAAEMVTLAQA-VNAQSLPAVQQDCLDIDLIRKLA 386

  Fly   526 KICSGNTCPLDAAVGGIVAQEVLKACSGKFTPIYQWLYFDALECLPTEGVE--EADAQPVGSRYD 588
            .:.:|:..|:.|.:||:.||||:|||||||.||.||||||||||||...|.  |....|..:|||
  Rat   387 YVAAGDLAPMSAFIGGLAAQEVMKACSGKFMPIRQWLYFDALECLPEHRVAFMEDKCLPRQNRYD 451

  Fly   589 SQIAIFGKKFQEKLADSKWFIVGAGAIGCELLKNFGMLGLGTG-NGQIFVTDMDLIEKSNLNRQF 652
            .|:|:||...||||...|:|:||||||||||||||.|:|||.| .|:|.|||||.||||||||||
  Rat   452 GQVAVFGSDLQEKLGKQKYFLVGAGAIGCELLKNFAMIGLGCGEGGEITVTDMDTIEKSNLNRQF 516

  Fly   653 LFRPHDVQKPKSMTAADAIKRMNPEVNVTAYELRVGAETEKVFSEDFFGKLDGVANALDNVDARI 717
            ||||.||.|.||.|||.|::.:||.:.|.:::.|||.|||.|:.:|||..||||||||||||||:
  Rat   517 LFRPWDVTKLKSETAAAAVRDINPHIRVCSHQNRVGPETEHVYDDDFFQNLDGVANALDNVDARL 581

  Fly   718 YMDRKCIFNRIPLVETGTLGTLGNVQVIVPFATESYSSSQDPPEKSIPICTLKNFPNAIEHTLQW 782
            ||||:|::.|.||:|:|||||.|||||:|||.|||||||||||||||||||||||||||||||||
  Rat   582 YMDRRCVYYRKPLLESGTLGTKGNVQVVVPFLTESYSSSQDPPEKSIPICTLKNFPNAIEHTLQW 646

  Fly   783 ARDAFEGVFKQSAENAAQYIADPQFTERIAKLPGIQPLEILDSIKKALIDDKPKSFAHCVEWARL 847
            |||.|||:|||||||..||:.||:|.||..:|.|.||||:|::|:.:|:..:|:::|.||.||..
  Rat   647 ARDEFEGLFKQSAENVNQYLMDPKFMERTLQLAGTQPLEVLEAIQCSLVLQRPQTWADCVTWAYQ 711

  Fly   848 YWEDQYVNQIKQLLFNFPPDQITSSGQPFWSGPKRCPDPLVFDVNDPMHLDFIYAAANLRAEVYG 912
            :|..||.:.|:|||.||||||:||||..|||||||||.||.||.|:|:|||::.|||||.|:.||
  Rat   712 HWHTQYSHNIQQLLHNFPPDQLTSSGVLFWSGPKRCPHPLTFDTNNPLHLDYVMAAANLFAQTYG 776

  Fly   913 IEQVRNRETIAELVQKVKVPEFKPRSGVKIETNEAAAAASANNFDDGELDQDRVDKIISELLKNA 977
            :|..::...:..|:|.:..|:|.|:||::|..:|....:::...||..|::      :...|...
  Rat   777 LEGSQDCAAVTTLLQSLPAPKFAPKSGIRIHVSEQELQSTSATVDDSHLEE------LKTSLPTP 835

  Fly   978 DK--SSKITPLEFEKDDDSNLHMDFIVACSNLRAANYKIPPADRHKSKLIAGKIIPAIATTTSVL 1040
            ||  ..|:.|::||||||||.|||||||.|||||.||.|||||||||||||||||||||||||.:
  Rat   836 DKMLGFKMHPIDFEKDDDSNFHMDFIVAASNLRAENYDIPPADRHKSKLIAGKIIPAIATTTSAV 900

  Fly  1041 SGLAVLEVIKLIVGHRDLVKFKNGFANLALPFMAFSEPLPAAKNTYYGKEWTLWDRFEVTG---- 1101
            .||..||:.|::.||:.|..|||.|.||||||.:||.||....:.||.|:|||||||:|.|
  Rat   901 VGLVCLELYKVVQGHQQLDSFKNSFINLALPFFSFSAPLAPGYHQYYDKKWTLWDRFDVQGLQPS 965

  Fly  1102 --ELSLQEFLNYFEENEKLKITMLSQGVSMLYSFFMPKAKCSERLPLPMSEVVRRVSKRRLEPHE 1164
              |::|::||:||:...||:||:||||||||||||||..|..|||..||:|:|.|||||:|..|.
  Rat   966 GEEMTLKQFLDYFKTEHKLEITILSQGVSMLYSFFMPATKLQERLDQPMTEIVSRVSKRKLGQHV 1030

  Fly  1165 RSLVFEICCNDVDGEDVEVPYVRYTL 1190
            :|||||:|||:..|:|:|||||||.:
  Rat  1031 KSLVFELCCNNESGDDIEVPYVRYII 1056

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Uba1	NP_477310.2	Ube1	194..1188	CDD:273603	595/1013 (59%)
		Ube1_repeat1	199..574	CDD:238768	212/383 (55%)
		E1_4HB	447..510	CDD:292809	29/62 (47%)
		Ube1_repeat2	606..1144	CDD:238767	336/546 (62%)
Uba1y	XP_008771907.1	Ube1	48..1054	CDD:273603	595/1013 (59%)
		Ube1_repeat1	53..433	CDD:238768	211/381 (55%)
		E1_4HB	301..365	CDD:292809	30/65 (46%)
		Ube1_repeat2	469..1010	CDD:238767	336/546 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	640	1.000	Domainoid score	I158
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1245	1.000	Inparanoid score	I165
OMA	1	1.010	-	-		QHG54221
OrthoDB	1	1.010	-	-		D139631at33208
OrthoFinder	1	1.000	-	-		FOG0001106
OrthoInspector	1	1.000	-	-		otm44707
orthoMCL	1	0.900	-	-		OOG6_100444
Panther	1	1.100	-	-	O	PTHR10953
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1782
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.980