DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Uba1 and uba-2

DIOPT Version :9

Sequence 1:	NP_477310.2	Gene:	Uba1 / 35998	FlyBaseID:	FBgn0023143	Length:	1191	Species:	Drosophila melanogaster
Sequence 2:	NP_001293154.1	Gene:	uba-2 / 24104970	WormBaseID:	WBGene00006700	Length:	582	Species:	Caenorhabditis elegans

Alignment Length:	475	Identity:	136/475 - (28%)
Similarity:	215/475 - (45%)	Gaps:	105/475 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   600 EKLADSKWFIVGAGAIGCELLKNFGMLGLGTGNGQIFVTDMDLIEKSNLNRQFLFRPHDVQKPKS 664
            ||:..||..::|||.||||||||..:    ||..::.|.|:|.|:.||||||||||...|...|:
Worm     9 EKIVQSKILVIGAGGIGCELLKNLAV----TGFRKVHVIDLDTIDISNLNRQFLFRKEHVSSSKA 69

  Fly   665 MTAADAIKRMNPEVNVTAYELRVGAETEKVFSEDFFGKLDGVANALDNVDARIYMDRKCIFNRIP 729
            .||...:|:..|::.:|.....:   .||.::.:||...|.|.|||||..||.|::|.|.....|
Worm    70 ATATQVVKQFCPQIELTFDHDSI---FEKKYNMEFFQAYDIVLNALDNRAARNYVNRMCHAANRP 131

  Fly   730 LVETGTLGTLGNVQVIVPFATESYSSSQDPPEK-SIPICTLKNFPNAIEHTLQWARDAFEGVFKQ 793
            |:::|:.|..|.|.||:...||.|.....|.:: :.|.||::|.|:...|...||:..|..:|.:
Worm   132 LIDSGSGGYFGQVSVIMRGKTECYECVDKPVQQTTYPGCTIRNTPSEHIHCTVWAKHVFNQLFGE 196

  Fly   794 -------SAENAAQYIADPQFTERIAKLPGIQPLEILDSIKKALIDDK----PKSFAHCVEW--- 844
                   |.:..|   .||..||.:.          .:..|:|:.::.    .:.:|..|::
Worm   197 VDIDDDVSPDMDA---VDPDNTEAVT----------TEKEKEAMKEEPAPVGTRQWAESVDYDAA 248

  Fly   845 ---ARLYWED-QYVNQIKQLLFNFPPDQITSSGQPFWSGPKRCPDPLVFDVNDPMHLDFIYAAAN 905
               .:|:..| :|:.:::.|                |...|| |.||.|           :.|::
Worm   249 KVFDKLFLHDIEYLCKMEHL----------------WKQRKR-PSPLEF-----------HTASS 285

  Fly   906 LRAEVYGI-EQVRNRETIAELVQKVKVPEFKPRSGVKIETNEAAAAASANNFDDGELDQDRVDKI 969
            ...|...: :..|:..:|..|....||                                  ....
Worm   286 TGGEPQSLCDAQRDDTSIWTLSTCAKV----------------------------------FSTC 316

  Fly   970 ISELLKNADKSSKITPLEFEKDDDSNLHMDFIVACSNLRAANYKIPPADRHKSKLIAGKIIPAIA 1034
            |.|||:.. ::.....|.|:|  |..:.|.|:.||:|:||..:.||...:...|.:||.||||||
Worm   317 IQELLEQI-RAEPDVKLAFDK--DHAIIMSFVAACANIRAKIFGIPMKSQFDIKAMAGNIIPAIA 378

  Fly  1035 TTTSVLSGLAVLEVIKLIVG 1054
            :|.::::|:.|.|.:::|.|
Worm   379 STNAIVAGIIVTEAVRVIEG 398

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Uba1	NP_477310.2	Ube1	194..1188	CDD:273603	136/475 (29%)
		Ube1_repeat1	199..574	CDD:238768
		E1_4HB	447..510	CDD:292809
		Ube1_repeat2	606..1144	CDD:238767	133/469 (28%)
uba-2	NP_001293154.1	ThiF	9..>172	CDD:279270	68/169 (40%)
		E1_enzyme_family	15..434	CDD:304554	133/469 (28%)
		UAE_UbL	442..526	CDD:291402
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0476
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810