DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Uba1 and Uba6

DIOPT Version :9

Sequence 1:	NP_477310.2	Gene:	Uba1 / 35998	FlyBaseID:	FBgn0023143	Length:	1191	Species:	Drosophila melanogaster
Sequence 2:	NP_766300.1	Gene:	Uba6 / 231380	MGIID:	1913894	Length:	1053	Species:	Mus musculus

Alignment Length:	1080	Identity:	456/1080 - (42%)
Similarity:	654/1080 - (60%)	Gaps:	78/1080 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   143 IESQEASSSASATSNSNNNVSSSNNNSNNSTNNRQLEGSSNMAGNSAAAGGDIDESLYSRQLYVL 207
            :..:|||.|:.....::.|:.:....|        ||               ||:.|||||.|||
Mouse    10 LSCEEASCSSWGACGASKNLPTMTTES--------LE---------------IDDGLYSRQRYVL 51

  Fly   208 GHDAMRRMANSDILLSGLGGLGLEIAKNVILGGVKSITLHDTATCGLHDLSSQFYLTEADI--GK 270
            |..||::||.|.:.|||:||||:|||||::|.|:|::|:|||..|...||.:.|:|.|.|:  .:
Mouse    52 GDTAMQKMAKSCVFLSGMGGLGVEIAKNLVLAGIKALTIHDTKKCQAWDLGTNFFLCEDDVVNER 116

  Fly   271 NRAEASCAQLAELNNYVRTVSHTGPLTE----EFLRKFRVVVLTNSDGEEQQRIAKFAHEN--GI 329
            |||||...::||||.||:..|.:.||.|    .||.|::.||||......|::|..|.|.:  .|
Mouse   117 NRAEAVLHRIAELNPYVQVSSSSAPLDETTDLSFLEKYQCVVLTEIKLTLQKKINNFCHSHCPPI 181

  Fly   330 ALIIAETRGLFAKVFCDFGESFTIYDQDGTQPISTMIASITHDAQGVVTCLDETRHGFNDGDYVT 394
            ..|.|:..|:::::|||||:.|.:.|..|.:|....|::||....|:||||:...|....|.::|
Mouse   182 KFISADVHGIWSRLFCDFGDEFEVSDTTGEEPKEIFISNITQANPGIVTCLESHPHKLETGQFLT 246

  Fly   395 FSEVQGMQELNGCQPLKITVLGPYTFSIGDTSKFGEYKSGGVATQVKMPKTISFKPLAQATEEPE 459
            |.|:.||..||| ...:|||:.|::||||||:|...|..||:|.|||.|||..|:||....:.|.
Mouse   247 FREIHGMTGLNG-SVQQITVISPFSFSIGDTTKLDPYLHGGIAVQVKTPKTFCFEPLESQIKHPR 310

  Fly   460 FLISDFAKLDSPATLHVAFNALSCYRKAHNGALPRPWNEEDANSFLEVVRASSNAEVDEK----- 519
            .||:||:|.::|..:|:|..||..:::.:| ..|....::|::..|::. .|.|..::||
Mouse   311 CLIADFSKPEAPLEIHLAMLALDQFQENYN-RKPNIRCQQDSDELLKLT-VSINETLEEKPEVNA 373

  Fly   520 -LVLQFAKICSGNTCPLDAAVGGIVAQEVLKACSGKFTPIYQWLYF---DALECLPTEGVEEADA 580
             :|...:....|...||.|||||:.:||||||.:|||:|:.||||.   |.:|.|...|.||  .
Mouse   374 DIVHWLSWTAQGFLPPLAAAVGGVASQEVLKAVTGKFSPLCQWLYLEAADTVESLGNPGHEE--F 436

  Fly   581 QPVGSRYDSQIAIFGKKFQEKLADSKWFIVGAGAIGCELLKNFGMLGLGTG--NGQIFVTDMDLI 643
            .|.|.|||:..|..|....:||.:...|:||.||||||:||||.:||:|||  .|.:.|||.|||
Mouse   437 LPRGDRYDAIRACIGNTLCQKLQNLNIFLVGCGAIGCEMLKNFALLGVGTGREKGMVTVTDPDLI 501

  Fly   644 EKSNLNRQFLFRPHDVQKPKSMTAADAIKRMNPEVNVTAYELRVGAETEKVFSEDFFGKLDGVAN 708
            ||||||||||||||.:|||||.|||:|..::||::.:.|:..:|...||.::|::|:.|.|.:..
Mouse   502 EKSNLNRQFLFRPHHIQKPKSYTAAEATLKINPQLKIDAHLNKVCPATESIYSDEFYTKQDIIIT 566

  Fly   709 ALDNVDARIYMDRKCIFNRIPLVETGTLGTLGNVQVIVPFATESYSSSQDPPEKSIPICTLKNFP 773
            |||||:||.|:|.:|:.|..||:::||:||.|:.::|||..||||:|.:||||:.||.||||:||
Mouse   567 ALDNVEARRYVDSRCLANLRPLLDSGTMGTKGHTEIIVPQLTESYNSHRDPPEEEIPFCTLKSFP 631

  Fly   774 NAIEHTLQWARDAFEGVF--KQSAENAAQYIADPQFTERIAKLPGIQPLEILDSIKKALIDDKPK 836
            .|||||:|||||.||..|  |.|..|.. :.|.|...:.:.|:...|.||....:.| |:..:|:
Mouse   632 AAIEHTIQWARDKFESSFSHKPSLFNKF-WQAYPSAEDVLQKIQNGQSLEGCFQVIK-LLSRRPR 694

  Fly   837 SFAHCVEWARLYWEDQYVNQIKQLLFNFPPDQITSSGQPFWSGPKRCPDPLVFDVNDPMHLDFIY 901
            .::.|||.|||.:|..:.::..|||..||.:.....|..||..|||.|.|:.||:|:|:||.|:.
Mouse   695 IWSQCVELARLKFEKYFNHKALQLLHCFPLETRLKDGSLFWQSPKRPPSPIKFDLNEPLHLSFLQ 759

  Fly   902 AAANLRAEVYGI---EQVRNRETIAELVQKVKVPEFKPRSGVKIETNEAAAAASANNFD----DG 959
            :||.|.|.||.|   |:..:..::.:::.:||:.||||.:.| ::|:|     :|...|    ..
Mouse   760 SAAKLYATVYCIPFSEKDLSVNSLMDILSEVKIEEFKPSNKV-VQTDE-----TARKPDHVPVSS 818

  Fly   960 ELDQDRVDKIISELLKN-ADKSS-KITPLEFEKDDDSNLHMDFIVACSNLRAANYKIPPADRHKS 1022
            |.:::.|.::...|..| |.||. ::|.|.||||||.|.|:|||.|.|||||..|.|.||||.|:
Mouse   819 EDERNAVFQLEEALSSNKATKSDLQMTVLSFEKDDDRNGHIDFITAASNLRAKMYSIEPADRFKT 883

  Fly  1023 KLIAGKIIPAIATTTSVLSGLAVLEVIKLIVGHRDLVKFKNGFANLALPFMAFSEPLPAAKNTY- 1086
            |.|||||||||||:|:.:|||..||:|| :.|......:||.|.|||:|.:.|:|.....|...
Mouse   884 KRIAGKIIPAIATSTAAVSGLVALEMIK-VAGGYPFDAYKNCFLNLAIPIIVFTETSEVRKTEIR 947

  Fly  1087 YGKEWTLWDRFEVTG--ELSLQEFLNYFEENEKLKITMLSQGVSMLYSFFMPKAKCSERLPLPMS 1149
            .|..:|:|||:.|.|  :.:|.:|:|..:||..::.||:.|||.|||...||..  ::||.|.|.
Mouse   948 NGISFTIWDRWTVHGKEDFTLSDFINAVKENYGIEPTMVVQGVKMLYVPVMPGH--AKRLKLTMH 1010

  Fly  1150 EVVRRVSKRRLEPHERSLVFEICCNDVDG-EDVEVPYVRY 1188
            ::|:..::::..  :.::.|   ..|.|| ||:..|.|||
Mouse  1011 KLVKPSTEKKYV--DLTVSF---APDADGDEDLPGPPVRY 1045

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Uba1	NP_477310.2	Ube1	194..1188	CDD:273603	446/1027 (43%)
		Ube1_repeat1	199..574	CDD:238768	166/391 (42%)
		E1_4HB	447..510	CDD:292809	18/62 (29%)
		Ube1_repeat2	606..1144	CDD:238767	253/553 (46%)
Uba6	NP_766300.1	Ube1	38..1046	CDD:273603	449/1044 (43%)
		Ube1_repeat1	43..432	CDD:238768	166/391 (42%)
		E1_4HB	299..362	CDD:292809	19/64 (30%)
		Ube1_repeat2	462..1005	CDD:238767	253/553 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0476
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54221
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001106
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100444
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.720