DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Uba1 and Uba1

DIOPT Version :9

Sequence 1:	NP_477310.2	Gene:	Uba1 / 35998	FlyBaseID:	FBgn0023143	Length:	1191	Species:	Drosophila melanogaster
Sequence 2:	NP_033483.2	Gene:	Uba1 / 22201	MGIID:	98890	Length:	1118	Species:	Mus musculus

Alignment Length:	1067	Identity:	626/1067 - (58%)
Similarity:	785/1067 - (73%)	Gaps:	31/1067 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly   148 ASSSASATSNSNNNVSSSN--NNSNNSTNNRQLEGSSNMAGNSAAAGG---DIDESLYSRQLYVL 207
            |...:|:..:....||..:  ..||.|.....|...|::..|..|..|   ||||||||||||||
Mouse    58 ALGMSSSPLSKKRRVSGPDPKPGSNCSPAQSALSEVSSVPTNGMAKNGSEADIDESLYSRQLYVL 122

  Fly   208 GHDAMRRMANSDILLSGLGGLGLEIAKNVILGGVKSITLHDTATCGLHDLSSQFYLTEADIGKNR 272
            ||:||:.:..|.:|:|||.|||:|||||:||||||::||||..|....||||||||.|.||||||
Mouse   123 GHEAMKMLQTSSVLVSGLRGLGVEIAKNIILGGVKAVTLHDQGTTQWADLSSQFYLREEDIGKNR 187

  Fly   273 AEASCAQLAELNNYVRTVSHTGPLTEEFLRKFRVVVLTNSDGEEQQRIAKFAHENGIALIIAETR 337
            ||.|..:|||||:||...::||||.|:||..|:|||||||..|.|.|:.:|.|..||.|::|:||
Mouse   188 AEVSQPRLAELNSYVPVTAYTGPLVEDFLSSFQVVVLTNSPLEAQLRVGEFCHSRGIKLVVADTR 252

  Fly   338 GLFAKVFCDFGESFTIYDQDGTQPISTMIASITHDAQGVVTCLDETRHGFNDGDYVTFSEVQGMQ 402
            |||.::||||||...:.|.:|.||:|.|::.:|.|..||||||||.||||..||:|:|||||||.
Mouse   253 GLFGQLFCDFGEEMVLTDSNGEQPLSAMVSMVTKDNPGVVTCLDEARHGFETGDFVSFSEVQGMI 317

  Fly   403 ELNGCQPLKITVLGPYTFSIGDTSKFGEYKSGGVATQVKMPKTISFKPLAQATEEPEFLISDFAK 467
            :||||||::|.|||||||||.|||.|.:|..||:.:|||:||.||||.|..:..||:|:::||||
Mouse   318 QLNGCQPMEIKVLGPYTFSICDTSNFSDYIRGGIVSQVKVPKKISFKSLPASLVEPDFVMTDFAK 382

  Fly   468 LDSPATLHVAFNALSCYRKAHNGALPRPWNEEDANSFL---EVVRASSNAEV-----DEKLVLQF 524
            ...||.||:.|.||..:...||.. |||.|||||...:   :.|.|.|...|     ||.|:.:.
Mouse   383 YSRPAQLHIGFQALHQFCALHNQP-PRPRNEEDATELVGLAQAVNARSPPSVKQNSLDEDLIRKL 446

  Fly   525 AKICSGNTCPLDAAVGGIVAQEVLKACSGKFTPIYQWLYFDALECLP--TEGVEEADAQPVGSRY 587
            |.:.:|:..|::|.:||:.||||:|||||||.||.||||||||||||  .|.:.|....|..:||
Mouse   447 AYVAAGDLAPINAFIGGLAAQEVMKACSGKFMPIMQWLYFDALECLPEDKEALTEEKCLPRQNRY 511

  Fly   588 DSQIAIFGKKFQEKLADSKWFIVGAGAIGCELLKNFGMLGLGTG-NGQIFVTDMDLIEKSNLNRQ 651
            |.|:|:||..|||||:..|:|:||||||||||||||.|:|||.| .|::.|||||.|||||||||
Mouse   512 DGQVAVFGSDFQEKLSKQKYFLVGAGAIGCELLKNFAMIGLGCGEGGEVVVTDMDTIEKSNLNRQ 576

  Fly   652 FLFRPHDVQKPKSMTAADAIKRMNPEVNVTAYELRVGAETEKVFSEDFFGKLDGVANALDNVDAR 716
            |||||.||.|.||.|||.|:::|||.:.||:::.|||.:||:::.:|||..||||||||||:|||
Mouse   577 FLFRPWDVTKLKSDTAAAAVRQMNPYIQVTSHQNRVGPDTERIYDDDFFQNLDGVANALDNIDAR 641

  Fly   717 IYMDRKCIFNRIPLVETGTLGTLGNVQVIVPFATESYSSSQDPPEKSIPICTLKNFPNAIEHTLQ 781
            :||||:|::.|.||:|:|||||.|||||::||.||||||||||||||||||||||||||||||||
Mouse   642 MYMDRRCVYYRKPLLESGTLGTKGNVQVVIPFLTESYSSSQDPPEKSIPICTLKNFPNAIEHTLQ 706

  Fly   782 WARDAFEGVFKQSAENAAQYIADPQFTERIAKLPGIQPLEILDSIKKALIDDKPKSFAHCVEWAR 846
            ||||.|||:|||.|||..||:.|.:|.||..:|.|.||||:|::::::|:..:|:::..||.||.
Mouse   707 WARDEFEGLFKQPAENVNQYLTDSKFVERTLRLAGTQPLEVLEAVQRSLVLQRPQTWGDCVTWAC 771

  Fly   847 LYWEDQYVNQIKQLLFNFPPDQITSSGQPFWSGPKRCPDPLVFDVNDPMHLDFIYAAANLRAEVY 911
            .:|..||.|.|:|||.||||||:||||.||||||||||.||.||||:.:|||::.|||||.|:.|
Mouse   772 HHWHTQYCNNIRQLLHNFPPDQLTSSGAPFWSGPKRCPHPLTFDVNNTLHLDYVMAAANLFAQTY 836

  Fly   912 GIEQVRNRETIAELVQKVKVPEFKPRSGVKIETNEAAAAASANNFDDGELDQDRVDKIISELLKN 976
            |:...::|..:|.|:|.|:||||.|:|||||..::....::..:.||..|::      :...|.:
Mouse   837 GLTGSQDRAAVASLLQSVQVPEFTPKSGVKIHVSDQELQSANASVDDSRLEE------LKATLPS 895

  Fly   977 ADK--SSKITPLEFEKDDDSNLHMDFIVACSNLRAANYKIPPADRHKSKLIAGKIIPAIATTTSV 1039
            .||  ..|:.|::||||||||.|||||||.|||||.||.|.||||||||||||||||||||||:.
Mouse   896 PDKLPGFKMYPIDFEKDDDSNFHMDFIVAASNLRAENYDISPADRHKSKLIAGKIIPAIATTTAA 960

  Fly  1040 LSGLAVLEVIKLIVGHRDLVKFKNGFANLALPFMAFSEPLPAAKNTYYGKEWTLWDRFEVTG--- 1101
            :.||..||:.|::.||:.|..:||||.||||||..|||||.|.::.||.:||||||||||.|
Mouse   961 VVGLVCLELYKVVQGHQQLDSYKNGFLNLALPFFGFSEPLAAPRHQYYNQEWTLWDRFEVQGLQP 1025

  Fly  1102 ---ELSLQEFLNYFEENEKLKITMLSQGVSMLYSFFMPKAKCSERLPLPMSEVVRRVSKRRLEPH 1163
               |::|::||:||:...||:|||||||||||||||||.||..|||..||:|:|.|||||:|..|
Mouse  1026 NGEEMTLKQFLDYFKTEHKLEITMLSQGVSMLYSFFMPAAKLKERLDQPMTEIVSRVSKRKLGRH 1090

  Fly  1164 ERSLVFEICCNDVDGEDVEVPYVRYTL 1190
            .|:||.|:||||..||||||||||||:
Mouse  1091 VRALVLELCCNDESGEDVEVPYVRYTI 1117

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Uba1	NP_477310.2	Ube1	194..1188	CDD:273603	611/1012 (60%)
		Ube1_repeat1	199..574	CDD:238768	222/384 (58%)
		E1_4HB	447..510	CDD:292809	29/65 (45%)
		Ube1_repeat2	606..1144	CDD:238767	339/546 (62%)
Uba1	NP_033483.2	ThiF	109..1115	CDD:330201	609/1011 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	642	1.000	Domainoid score	I165
eggNOG	1	0.900	-	-		E1_COG0476
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H22002
Inparanoid	1	1.050	1245	1.000	Inparanoid score	I181
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54221
OrthoDB	1	1.010	-	-		D139631at33208
OrthoFinder	1	1.000	-	-		FOG0001106
OrthoInspector	1	1.000	-	-		otm42640
orthoMCL	1	0.900	-	-		OOG6_100444
Panther	1	1.100	-	-	O	PTHR10953
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1577
SonicParanoid	1	1.000	-	-		X1782
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.870