Protein Alignment Uba1 and rfl-1

DIOPT Version :10

• Sequence 1: NP_477310.2
• Gene: Uba1 / 35998
• FlyBaseID: FBgn0023143
• Length: 1191
• Species: Drosophila melanogaster
• Sequence 2: NP_498534.2
• Gene: rfl-1 / 175982
• WormBaseID: WBGene00004341
• Length: 430
• Species: Caenorhabditis elegans
• Alignment Length: 609
• Identity: 134/609 - (22%)
• Similarity: 208/609 - (34%)
• Gaps: 257/609 - (42%)

  Fly   600 EKLADSKWFIVGAGAIGCELLKNFGMLGLGTGNGQIFVTDMDLIEKSNLNRQFLFRPHDVQKPKS 664
            |.|.::|..::|||.:|||||||..:.|..|    |.|.|||.|:.||||||||||..||.|.|:
 Worm    38 EALQNTKILVIGAGGLGCELLKNLALSGFRT----IEVIDMDTIDVSNLNRQFLFRESDVGKSKA 98

  Fly   665 MTAADAIKRMNPEVNVTAYELRVGAETEKVFSEDFFGKLDGVANALDNVDARIYM---------- 719
            ..||..:::......|||:..|:..:     .::|:.|...:...||::.||.::
 Worm    99 EVAAAFVQQRVVGCQVTAHNCRIEDK-----GQEFYRKFSIIICGLDSIPARRWINGMLCDLVLE 158

  Fly   720 ------DRKCIFNRIPLVETGTLGTLGNVQVIVPFATESYSSSQD--PPEKSIPICTLKNFPNAI 776
                  |...|   ||:::.||.|..||.:||.|..|.....:.|  ||:.:.|:||:.:.|
 Worm   159 MADGKPDENTI---IPMIDGGTEGFKGNARVIYPKFTACIDCTLDLYPPQVNFPLCTIAHTP--- 217

  Fly   777 EHTLQWARDAFEGVFKQSAENAAQYIADPQFTERIAKLPGIQPLEILDSIKKALIDDKPKSFAHC 841
                                                :||                       .||
 Worm   218 ------------------------------------RLP-----------------------EHC 223

  Fly   842 VEWAR-LYWEDQYVNQIKQLLFNFPPDQITSSGQPFWSGPKRCPDPLVFDVNDPMHLDFIYAAAN 905
            :|:.: :.|.::                     :||        :.:..|.:||:|::::...|:
 Worm   224 IEYIKVVVWPEE---------------------KPF--------EGVSLDADDPIHVEWVLERAS 259

  Fly   906 LRAEVYGIEQVRNRETIAELVQKVKVPEFKPRSGVKIETNEAAAAASANNFDDGELDQDRVDKII 970
            ||||.|.|..|..|.|                |||
 Worm   260 LRAEKYNIRGVDRRLT----------------SGV------------------------------ 278

  Fly   971 SELLKNADKSSKITPLEFEKDDDSNLHMDFIVACSNLRAANYKIPPADRHKSKLIAGKIIPAIAT 1035
               ||                                                    :||||:|:
 Worm   279 ---LK----------------------------------------------------RIIPAVAS 288

  Fly  1036 TTSVLSGLAVLEVIKLIVGHRDLVKFKNGFANLALPFMAFSEPLPAAKN----TYYGKEWTLWDR 1096
            |.:|::....||.:||..   ::.|..:.:.|......|::..:...|:    |..|....
 Worm   289 TNAVIAASCALEALKLAT---NIAKPIDNYLNFTQIHGAYTSVVSMMKDDNCLTCSGGRLP---- 346

  Fly  1097 FEVTGELSLQEFLNYFEENEKLKITMLSQGVSMLY--SFFMPKAKCSERLPLPMSEVVRRVSKRR 1159
            |||:...:|:..:....|...||...|:.....||  |.|||:              ..:.||..
 Worm   347 FEVSPSSTLESLIIRLSERFHLKHPTLATSTRKLYCISSFMPQ--------------FEQESKEN 397

  Fly  1160 LEPHERSLVFEICCNDVDGEDVEV 1183
            |....:.||       .|||::.|
 Worm   398 LHTSMKDLV-------SDGEEILV 414

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Uba1	NP_477310.2	Ube1	194..1188	CDD:273603	134/609 (22%)
rfl-1	NP_498534.2	Uba3_RUB	44..341	CDD:238765	108/503 (21%)
		E2_bind	349..429	CDD:462611	21/87 (24%)