DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Uba1 and LOC103694557

DIOPT Version :9

Sequence 1:	NP_477310.2	Gene:	Uba1 / 35998	FlyBaseID:	FBgn0023143	Length:	1191	Species:	Drosophila melanogaster
Sequence 2:	XP_008771915.1	Gene:	LOC103694557 / 103694557	RGDID:	9252298	Length:	1057	Species:	Rattus norvegicus

Alignment Length:	1066	Identity:	607/1066 - (56%)
Similarity:	771/1066 - (72%)	Gaps:	31/1066 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly   145 SQEASSSASATSNSNNNVSSSNNNSNNSTNNRQLEGSSNMAGNSAAAGGDIDESLYSRQLYVLGH 209
            |....|.....|..::.|.||.:::::.........:|.|:.|...   ||||||||||||||||
  Rat     2 SSSVLSKKRRVSGPDSKVDSSWSSTHSVMFGVPPGPNSGMSKNKEM---DIDESLYSRQLYVLGH 63

  Fly   210 DAMRRMANSDILLSGLGGLGLEIAKNVILGGVKSITLHDTATCGLHDLSSQFYLTEADIGKNRAE 274
            :||:.:..|.:|:|||.|||:|||||:||||||::||||..|....||||||||.|.||||||||
  Rat    64 EAMKHLQTSSVLISGLQGLGVEIAKNIILGGVKAVTLHDQGTAQWADLSSQFYLHEEDIGKNRAE 128

  Fly   275 ASCAQLAELNNYVRTVSHTGPLTEEFLRKFRVVVLTNSDGEEQQRIAKFAHENGIALIIAETRGL 339
            .|..:|||||:||...::||||.::||..|:||||||:..|.|.::.:|.|.:||.|::|:||||
  Rat   129 VSQPRLAELNSYVPVHTYTGPLVDDFLSGFQVVVLTNTPLEYQLQVGEFCHSHGIKLVVADTRGL 193

  Fly   340 FAKVFCDFGESFTIYDQDGTQPISTMIASITHDAQGVVTCLDETRHGFNDGDYVTFSEVQGMQEL 404
            ..::||||||...:.|.:|.||:|.|::.||.:..|:||||:||||||..||:|:|:|||||.||
  Rat   194 VGQLFCDFGEEMILTDANGEQPLSAMVSMITKENPGIVTCLEETRHGFESGDFVSFTEVQGMSEL 258

  Fly   405 NGCQPLKITVLGPYTFSIGDTSKFGEYKSGGVATQVKMPKTISFKPLAQATEEPEFLISDFAKLD 469
            ||..|::|.|||||:|||.|||.|.||..||:.:|||:.:.||||.|..:..||||:|:||||..
  Rat   259 NGIGPMEIKVLGPYSFSICDTSSFSEYTRGGIVSQVKVSQKISFKSLVASLAEPEFVITDFAKCC 323

  Fly   470 SPATLHVAFNALSCYRKAHNGALPRPWNEEDANSFLEVVRASSNAE---------VDEKLVLQFA 525
            .||.||:.|.||..:...|:.. |||.|||||...:.:.:| .||:         :|..|:.:.|
  Rat   324 RPAQLHIGFQALHQFCTQHSRP-PRPHNEEDAAEMVTLAQA-VNAQSLPAVQQDCLDIDLIRKLA 386

  Fly   526 KICSGNTCPLDAAVGGIVAQEVLKACSGKFTPIYQWLYFDALECLPTEGVE--EADAQPVGSRYD 588
            .:.:|:..|:.|.:||:.||||:|||||||.||.||||||||||||...|.  |....|..:|||
  Rat   387 YVAAGDLAPMSAFIGGLAAQEVMKACSGKFMPIRQWLYFDALECLPEHRVAFMEDKCLPRQNRYD 451

  Fly   589 SQIAIFGKKFQEKLADSKWFIVGAGAIGCELLKNFGMLGLGTG-NGQIFVTDMDLIEKSNLNRQF 652
            .|:|:||...||||...|:|:||||||||||||||.|:|||.| .|:|.|||||.||||||||||
  Rat   452 GQVAVFGSDLQEKLGKQKYFLVGAGAIGCELLKNFAMIGLGCGEGGEITVTDMDTIEKSNLNRQF 516

  Fly   653 LFRPHDVQKPKSMTAADAIKRMNPEVNVTAYELRVGAETEKVFSEDFFGKLDGVANALDNVDARI 717
            ||||.||.|.||.|||.|::.:||.:.|.:::.|||.|||.|:.:|||..||||||||||||||:
  Rat   517 LFRPWDVTKLKSETAAAAVRDINPHIRVCSHQNRVGPETEHVYDDDFFQNLDGVANALDNVDARL 581

  Fly   718 YMDRKCIFNRIPLVETGTLGTLGNVQVIVPFATESYSSSQDPPEKSIPICTLKNFPNAIEHTLQW 782
            ||||:|::.|.||:|:|||||.|||||:|||.|||||||||||||||||||||||||||||||||
  Rat   582 YMDRRCVYYRKPLLESGTLGTKGNVQVVVPFLTESYSSSQDPPEKSIPICTLKNFPNAIEHTLQW 646

  Fly   783 ARDAFEGVFKQSAENAAQYIADPQFTERIAKLPGIQPLEILDSIKKALIDDKPKSFAHCVEWARL 847
            |||.|||:|||||||..||:.||:|.||..:|.|.||||:|::|:.:|:..:|:::|.||.||..
  Rat   647 ARDEFEGLFKQSAENVNQYLMDPKFMERTLQLAGTQPLEVLEAIQCSLVLQRPQTWADCVTWAYQ 711

  Fly   848 YWEDQYVNQIKQLLFNFPPDQITSSGQPFWSGPKRCPDPLVFDVNDPMHLDFIYAAANLRAEVYG 912
            :|..||.:.|:|||.||||||:||||..|||||||||.||.||.|:|:|||::.|||||.|:.||
  Rat   712 HWHTQYSHNIQQLLHNFPPDQLTSSGVLFWSGPKRCPHPLTFDTNNPLHLDYVMAAANLFAQTYG 776

  Fly   913 IEQVRNRETIAELVQKVKVPEFKPRSGVKIETNEAAAAASANNFDDGELDQDRVDKIISELLKNA 977
            :|..::...:..|:|.:..|:|.|:||::|..:|....:::...||..|::      :...|...
  Rat   777 LEGSQDCAAVTTLLQSLPAPKFAPKSGIRIHVSEQELQSTSATVDDSHLEE------LKTSLPTP 835

  Fly   978 DK--SSKITPLEFEKDDDSNLHMDFIVACSNLRAANYKIPPADRHKSKLIAGKIIPAIATTTSVL 1040
            ||  ..|:.|::||||||||.|||||||.|||||.||.|||||||||||||||||||||||||.:
  Rat   836 DKMLGFKMHPIDFEKDDDSNFHMDFIVAASNLRAENYDIPPADRHKSKLIAGKIIPAIATTTSAV 900

  Fly  1041 SGLAVLEVIKLIVGHRDLVKFKNGFANLALPFMAFSEPLPAAKNTYYGKEWTLWDRFEVTG---- 1101
            .||..||:.|::.||:.|..|||.|.||||||.:||.||....:.||.|:|||||||:|.|
  Rat   901 VGLVCLELYKVVQGHQQLDSFKNSFINLALPFFSFSAPLAPGYHQYYDKKWTLWDRFDVQGLQPS 965

  Fly  1102 --ELSLQEFLNYFEENEKLKITMLSQGVSMLYSFFMPKAKCSERLPLPMSEVVRRVSKRRLEPHE 1164
              |::|::||:||:...||:|||||||||||||||||..|..|||..||:|:|.|||||:|..|.
  Rat   966 GEEMTLKQFLDYFKTEHKLEITMLSQGVSMLYSFFMPATKLQERLDQPMTEIVSRVSKRKLGQHV 1030

  Fly  1165 RSLVFEICCNDVDGEDVEVPYVRYTL 1190
            :|||||:|||:..|:|:|||||||.:
  Rat  1031 KSLVFELCCNNESGDDIEVPYVRYII 1056

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Uba1	NP_477310.2	Ube1	194..1188	CDD:273603	596/1013 (59%)
		Ube1_repeat1	199..574	CDD:238768	212/383 (55%)
		E1_4HB	447..510	CDD:292809	29/62 (47%)
		Ube1_repeat2	606..1144	CDD:238767	337/546 (62%)
LOC103694557	XP_008771915.1	Ube1	48..1054	CDD:273603	596/1013 (59%)
		Ube1_repeat1	53..433	CDD:238768	211/381 (55%)
		E1_4HB	301..365	CDD:292809	30/65 (46%)
		Ube1_repeat2	469..1010	CDD:238767	337/546 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D139631at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010