Protein Alignment Uba1 and UBA2

DIOPT Version :9

• Sequence 1: NP_477310.2
• Gene: Uba1 / 35998
• FlyBaseID: FBgn0023143
• Length: 1191
• Species: Drosophila melanogaster
• Sequence 2: XP_005258461.2
• Gene: UBA2 / 10054
• HGNCID: 30661
• Length: 752
• Species: Homo sapiens
• Alignment Length: 600
• Identity: 167/600 - (27%)
• Similarity: 263/600 - (43%)
• Gaps: 132/600 - (22%)

  Fly   625 MLGLGTGNGQIFVTDMDLIEKSNLNRQFLFRPHDVQKPKSMTAADAIKRMNPEVNVTAYELRVGA 689
            :|||     ||   |:|.|:.|||||||||:...|.:.|:..|.:::.:..|:.|:.||.
Human   154 VLGL-----QI---DLDTIDVSNLNRQFLFQKKHVGRSKAQVAKESVLQFYPKANIVAYH----- 205

  Fly   690 ETEKVFSED----FFGKLDGVANALDNVDARIYMDRKCIFNRIPLVETGTLGTLGNVQVIVPFAT 750
              :.:.:.|    ||.:...|.|||||..||.:::|.|:...:||:|:||.|.||.|..|....|
Human   206 --DSIMNPDYNVEFFRQFILVMNALDNRAARNHVNRMCLAADVPLIESGTAGYLGQVTTIKKGVT 268

  Fly   751 ESYSSSQDPPEKSIPICTLKNFPNAIEHTLQWARDAFEGVFKQSAENAAQYI----ADPQFTERI 811
            |.|.....|.:::.|.||::|.|:...|.:.||:..|..:|.:  |:|.|.:    |||:
Human   269 ECYECHPKPTQRTFPGCTIRNTPSEPIHCIVWAKYLFNQLFGE--EDADQEVSPDRADPE----- 326

  Fly   812 AKLPGIQPLEILDSIKKALIDDKPKSFAHCVEWARLYWEDQ-------YVNQIKQLLFNFPPDQI 869
               ...:|.| .::..:|..:|.........|||:....|.       :.:.|:.||
Human   327 ---AAWEPTE-AEARARASNEDGDIKRISTKEWAKSTGYDPVKLFTKLFKDDIRYLL-------- 379

  Fly   870 TSSGQPFWSGPKRCPDPLVFDVNDPMHLDFIYAAANLRAEVYGIEQVRNRETIAELVQKVKVPEF 934
              :....|.  ||.|         |:.||:        |||    |.:..||.|...|.
Human   380 --TMDKLWR--KRKP---------PVPLDW--------AEV----QSQGEETNASDQQN------ 413

  Fly   935 KPRSGVKIETNEAAAAASANNFDDGELDQDRVDKIISELLKN-----ADKSSKITPLEFEKDDDS 994
            :|:.|:|               |...||.....::.|:.::.     |:|... ..|.::|||.|
Human   414 EPQLGLK---------------DQQVLDVKSYARLFSKSIETLRVHLAEKGDG-AELIWDKDDPS 462

  Fly   995 NLHMDFIVACSNLRAANYKIPPADRHKSKLIAGKIIPAIATTTSVLSGLAVLEVIKLIVGHRD-- 1057
              .|||:.:.:|||...:.:....|...|.:||.||||||||.:|::||.|||.:|::.|..|
Human   463 --AMDFVTSAANLRMHIFSMNMKSRFDIKSMAGNIIPAIATTNAVIAGLIVLEGLKILSGKIDQC 525

  Fly  1058 ----LVKFKNGFANLALPFMAFSEPLPAAKNTYYGKEWTLWDRFEVTGELSLQE--FLNYFEENE 1116
                |.|..|....|.:| .|...|.|   |.|     ....:.|||..|::.:  .|...::..
Human   526 RTIFLNKQPNPRKKLLVP-CALDPPNP---NCY-----VCASKPEVTVRLNVHKVTVLTLQDKIV 581

  Fly  1117 KLKITMLSQGV-------SMLYSFFMPKAKCSERLPLPMSEV-VRRVSKRRLEP--HERSLVFEI 1171
            |.|..|::..|       ::|.|....:.:.:....|  ||. :|..|:.:.:.  .:.:|:..|
Human   582 KEKFAMVAPDVQIEDGKGTILISSEEGETEANNHKKL--SEFGIRNGSRLQADDFLQDYTLLINI 644

  Fly  1172 CCNDVDGEDVEVPYV 1186
            ..::..|:|||...|
Human   645 LHSEDLGKDVEFEVV 659

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Uba1	NP_477310.2	Ube1	194..1188	CDD:273603	166/599 (28%)
		Ube1_repeat1	199..574	CDD:238768
		E1_4HB	447..510	CDD:292809
		Ube1_repeat2	606..1144	CDD:238767	155/553 (28%)
UBA2	XP_005258461.2	Uba2_SUMO	159..556	CDD:238766	140/483 (29%)
		UBA_e1_thiolCys	291..474	CDD:287545	56/250 (22%)
		UAE_UbL	564..650	CDD:291402	15/87 (17%)
		UBA2_C	661..747	CDD:292812

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0476
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810