DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mmp2 and Mmp1b

DIOPT Version :9

Sequence 1:	NP_995788.1	Gene:	Mmp2 / 35997	FlyBaseID:	FBgn0033438	Length:	758	Species:	Drosophila melanogaster
Sequence 2:	NP_114396.3	Gene:	Mmp1b / 83996	MGIID:	1933847	Length:	463	Species:	Mus musculus

Alignment Length:	711	Identity:	167/711 - (23%)
Similarity:	246/711 - (34%)	Gaps:	261/711 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LATLLALFAQSMCIQELSLPPEGSHSTAATR---SKKAKTAISEDIMYNYLMQFDYLPKSDLETG 68
            |..||.|:|.|            |:|....:   .|..||      ::.||..:..|.| :::..
Mouse     4 LPLLLLLWAAS------------SYSFPVIQDGLQKNVKT------VWKYLENYYNLGK-NMQAK 49

  Fly    69 ALRTEDQLKEAIRSLQSFGNITVTGEIDSATARLIQKPRCGVGDRRSADSFSPDNLYHEIGSNVR 133
            .:..::.:.|.:|.:|....:.|||..|..|.|.::||||||.|      .:|..:.|
Mouse    50 NVNGKEVMAEKLRQMQQLFGLKVTGNSDPETLRAMKKPRCGVPD------VAPYAITH------- 101

  Fly   134 VRRFALQGPKWSRTDLTWSMVNRSMPDASK--VERMVQTALDVWANHSKLTFREVYSDQADIQIL 196
                  ..|:|::|.||:|::|.: |..||  ||..:..|..||::.:.|||:.|:.::.||.:.
Mouse   102 ------NNPRWTKTHLTYSILNYT-PYLSKAVVEDAIARAFRVWSDVTPLTFQRVFEEEGDIVLS 159

  Fly   197 FARRAHGDGYKFDGPGQVLAHAFYPGEGRGGDAHFDADETWNFDGESDDSHGTNFLNVALHELGH 261
            |.|..|||.|.|||.....||||.||.|.||:.|:|.|:.|     :|::...|...|..|||||
Mouse   160 FHRGDHGDLYTFDGSKYHFAHAFLPGLGLGGNVHYDLDQKW-----TDNNEDFNLFYVTAHELGH 219

  Fly   262 SLGLAHSAIPDAVMFPWY--QNNEVAGNLPDDDRYGIQQLYGTKEKTWGPYKPQTTTTTTTTTTM 324
            ||||:||...:|:|||.|  .|.:...|..|.:|  ||.|||
Mouse   220 SLGLSHSNDEEALMFPSYTWSNKDFVLNQDDINR--IQALYG----------------------- 259

  Fly   325 RAMIYRADKPAYWPWNNPSNNPNNDRNRARERQEEERRRQEKERRRQEEERRHQEEERRRQVEER 389
                             ||.||
Mouse   260 -----------------PSPNP------------------------------------------- 264

  Fly   390 QRQEEERWRQEQERQEEENRRRKIEHKSQWERNPSKERNRPRERQEMERRRQEQERQEQERQEQE 454

Mouse   265 ----------------------------------------------------------------- 264

  Fly   455 DRRRERERDRQLEWERRNRNGAREPVTPTANTTPRPTNKPYPTVHRQHHHHNKPRKPKPDSCMTY 519
                                      ....:.|..|.|                      |.:|
Mouse   265 --------------------------IQLTDATLDPCN----------------------SGLT- 280

  Fly   520 YDAISIIRGELFIFRGPYLWRIGTSGLYNGYPTEIRRHWSALPENLTKVDAVYE-NKQRQIVFFI 583
            :|||...|||:..|:..:..|: .|.|.......|...|..||   .|.||.|| :...::.||.
Mouse   281 FDAIITYRGEVIFFKDRFYIRV-ISFLPEPLIDVIDLIWPNLP---GKFDAAYEVSGVDELRFFK 341

  Fly   584 GREYYVFNSVMLAPGFPKPLAS-LGLPPTLTHIDASFVWGHNNRTYMTSGTLYWRIDDYTGQVEL 647
            |.:.:......:..|||..:.| .|.|..:|:|||:.......:||.....:|||.|:.|..::.
Mouse   342 GSKVWAVQEQNVLEGFPMDIQSFFGFPSNVTNIDAAVCEEETGKTYFFVDHMYWRYDENTRSMDP 406

  Fly   648 DYPRDMS-IWSGVGYNIDAAFQYLDGKTYFFKNLGYWEFNDDRMKVAHARAKLSARRWMQC 707
            .|||.:: .:.|:.|.:|...|..|...:|.:::.| .||   :|............|..|
Mouse   407 GYPRLIAEDFPGIDYKVDDVIQKEDNFYFFHQSIQY-RFN---LKTRRIDDSSDINTWFNC 463

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mmp2	NP_995788.1	Peptidase_M10	143..301	CDD:278824	68/161 (42%)
		ZnMc_MMP	143..301	CDD:239805	68/161 (42%)
		HX	513..707	CDD:238046	55/196 (28%)
Mmp1b	NP_114396.3	PG_binding_1	28..84	CDD:279773	15/62 (24%)
		Cysteine switch. /evidence=ECO:0000250	87..94		6/12 (50%)
		Metalloprotease. /evidence=ECO:0000250	95..273		78/372 (21%)
		Peptidase_M10	105..259	CDD:278824	68/161 (42%)
		ZnMc_MMP	105..259	CDD:239805	68/161 (42%)
		HX	273..463	CDD:238046	57/220 (26%)
		Hemopexin 1	278..321		13/44 (30%)
		Hemopexin 2	322..368		14/48 (29%)
		Hemopexin 3	371..419		14/47 (30%)
		Hemopexin 4	420..463		10/46 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	149	1.000	Domainoid score	I4394
eggNOG	1	0.900	-	-		E1_KOG1565
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1075463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10201
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X44
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.920