DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mmp2 and Mmp1a

DIOPT Version :9

Sequence 1:	NP_995788.1	Gene:	Mmp2 / 35997	FlyBaseID:	FBgn0033438	Length:	758	Species:	Drosophila melanogaster
Sequence 2:	NP_114395.1	Gene:	Mmp1a / 83995	MGIID:	1933846	Length:	464	Species:	Mus musculus

Alignment Length:	674	Identity:	166/674 - (24%)
Similarity:	237/674 - (35%)	Gaps:	253/674 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 DIMYNYLMQFDYLPKSDLETGALRTEDQLKEAIRSLQSFGNITVTGEIDSATARLIQKPRCGVGD 112
            :.::.||..:..|.| :::...:..::.:.|.:|.:|....:.|||..|..|.|.::||||||.|
Mouse    30 ETVWKYLENYYNLGK-NMQAKNVNGKEMMAEKLRQMQQLFGLKVTGNSDPETLRAMKKPRCGVPD 93

  Fly   113 RRSADSFSPDNLYHEIGSNVRVRRFALQGPKWSRTDLTWSMVNRS--MPDASKVERMVQTALDVW 175
                  .:|..:.|             ..|:|::|.||:|::|.:  :|.| .||..:..|..||
Mouse    94 ------VAPYAITH-------------NNPRWTKTHLTYSILNYTPYLPKA-VVEDAIARAFRVW 138

  Fly   176 ANHSKLTFREVYSDQADIQILFARRAHGDGYKFDGPGQVLAHAFYPGEGRGGDAHFDADETWNFD 240
            ::.:.|||:.|:.::.||.:.|.|..|||...||||...|||.|.||.|.|||.|:|.||||
Mouse   139 SDVTPLTFQRVFEEEGDIVLSFHRGDHGDNNPFDGPNYKLAHTFQPGPGLGGDVHYDLDETW--- 200

  Fly   241 GESDDSHGTNFLNVALHELGHSLGLAHSAIPDAVMFP---WYQNNEVAGNLPDDDRYGIQQLYGT 302
              ::.|...|...|..|||||||||.||:...|:|||   ||..:.|   |..||...||.|||
Mouse   201 --TNSSENFNLFYVTAHELGHSLGLTHSSDIGALMFPSYTWYTEDFV---LNQDDINRIQDLYG- 259

  Fly   303 KEKTWGPYKPQTTTTTTTTTTMRAMIYRADKPAYWPWNNPSNNPNNDRNRARERQEEERRRQEKE 367
                                                   ||.|
Mouse   260 ---------------------------------------PSPN---------------------- 263

  Fly   368 RRRQEEERRHQEEERRRQVEERQRQEEERWRQEQERQEEENRRRKIEHKSQWERNPSKERNRPRE 432

Mouse   264 ----------------------------------------------------------------- 263

  Fly   433 RQEMERRRQEQERQEQERQEQEDRRRERERDRQLEWERRNRNGAREPVTPTANTTPRPTNKPYPT 497
                                                          |:.||..|||.|.|....
Mouse   264 ----------------------------------------------PIQPTGATTPHPCNGDLT- 281

  Fly   498 VHRQHHHHNKPRKPKPDSCMTYYDAISIIRGELFIFRGPYLWRIGTSGLYNGYPTE-----IRRH 557
                                  :|||:..|||:|.|:|.:..|:      |.:..|     |...
Mouse   282 ----------------------FDAITTFRGEVFFFKGRFYIRV------NRFMPEPELNLIGIL 318

  Fly   558 WSALPENLTKVDAVYENKQ-RQIVFFIGREYYVFNSVMLAPGFPKPLAS-LGLPPTLTHIDASFV 620
            |..||   .|:||.||... .|:.:|.|.:.:......:..|||:.:.| .|.|..:|||||:..
Mouse   319 WPNLP---VKLDAAYEASMIDQVRYFKGSKVWAVQEQSVLRGFPRDIHSFFGFPSNVTHIDAAVC 380

  Fly   621 WGHNNRTYMTSGTLYWRIDDYTGQVELDYPR-DMSIWSGVGYNIDAAFQYLDGKT-YFFKNLGYW 683
            .....:||.....:|||.|:.|..::..||| ....:.|:...:|..||  .|:. |||......
Mouse   381 EEETGKTYFFVDHMYWRYDENTQSMDPGYPRLTAEDFPGIDDKVDDVFQ--KGENFYFFHQSVQH 443

  Fly   684 EFNDDRMKVAHARAKLSARRWMQC 707
            .||....:|..:|   .:..|..|
Mouse   444 RFNLQIRRVDDSR---DSSTWFNC 464

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mmp2	NP_995788.1	Peptidase_M10	143..301	CDD:278824	71/162 (44%)
		ZnMc_MMP	143..301	CDD:239805	71/162 (44%)
		HX	513..707	CDD:238046	58/202 (29%)
Mmp1a	NP_114395.1	PG_binding_1	26..84	CDD:279773	13/54 (24%)
		Cysteine switch. /evidence=ECO:0000250	87..94		6/12 (50%)
		Metalloprotease	95..274		84/373 (23%)
		Peptidase_M10	105..259	CDD:278824	71/162 (44%)
		ZnMc_MMP	105..259	CDD:239805	71/162 (44%)
		HX	273..464	CDD:238046	61/227 (27%)
		Hemopexin 1	273..322		17/77 (22%)
		Hemopexin 2	323..369		14/48 (29%)
		Hemopexin 3	372..420		15/47 (32%)
		Hemopexin 4	421..464		12/47 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	149	1.000	Domainoid score	I4394
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1075463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10201
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3504
SonicParanoid	1	1.000	-	-		X44
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	7.050