Protein Alignment Mmp2 and Mmp24

DIOPT Version :10

• Sequence 1: NP_995788.1
• Gene: Mmp2 / 35997
• FlyBaseID: FBgn0033438
• Length: 758
• Species: Drosophila melanogaster
• Sequence 2: NP_113945.1
• Gene: Mmp24 / 83513
• RGDID: 620202
• Length: 618
• Species: Rattus norvegicus
• Alignment Length: 723
• Identity: 197/723 - (27%)
• Similarity: 288/723 - (39%)
• Gaps: 207/723 - (28%)

  Fly    10 LLALFAQSMCIQELSLPPEGSHSTAATRSKKAKTAISEDIMYNYLMQFDYLPKSDLETGALRTED 74
            ||.|.....|:            .||..:.|...|.:.....|:|..:.||...:....||.:..
  Rat    26 LLPLLPALCCL------------AAAAGAGKPAGADAPFAGQNWLKSYGYLLPYESRASALHSGK 78

  Fly    75 QLKEAIRSLQSFGNITVTGEIDSATARLIQKPRCGVGDRRSADSFSPDNLYHEIGSNVRVRRFAL 139
            .|:.|:.::|.|..|.|||.:|..|...::||||||.|            :..:....|.:|:||
  Rat    79 ALQSAVSTMQQFYGIPVTGVLDQTTIEWMKKPRCGVPD------------HPHLSRRRRNKRYAL 131

  Fly   140 QGPKWSRTDLTWSMVNRSMPDASKVE--RMVQTALDVWANHSKLTFREV-----YSD--QADIQI 195
            .|.||.:..:|:|:.|.: |...:::  :.::.|.|||...:.|||.||     .||  :|||.|
  Rat   132 TGQKWRQKHITYSIHNYT-PKVGELDTRKAIRQAFDVWQKVTPLTFEEVPYHEIKSDRKEADIMI 195

  Fly   196 LFARRAHGDGYKFDGPGQVLAHAFYPGEGRGGDAHFDADETWNFDGESDDSHGTNFLNVALHELG 260
            .||...|||...|||.|..||||::||.|.|||.|||:||.|.....:.|  |.:...||:||||
  Rat   196 FFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNANHD--GNDLFLVAVHELG 258

  Fly   261 HSLGLAHSAIPDAVMFPWYQNNEVAG-NLPDDDRYGIQQLYGTKEKTWGPYKPQTTTTTTTTTTM 324
            |:|||.||..|.|:|.|:||..|... .||.||..|||::||.      |.:|...|....|..:
  Rat   259 HALGLEHSNDPSAIMAPFYQYMETHNFKLPQDDLQGIQKIYGP------PAEPLEPTRPLPTLPV 317

  Fly   325 RAMIYRADKPAYWPWNNPSNNPNNDRNRARERQEEERRRQEKERRRQEEERRHQEEERRRQVEER 389
            |.:            ::||                              ||:|
  Rat   318 RRI------------HSPS------------------------------ERKH------------ 328

  Fly   390 QRQEEERWRQEQERQEEENRRRKIEHKSQWERNPSKERNRPRERQEMERRRQEQERQEQERQEQE 454
                                                                       |||
  Rat   329 -----------------------------------------------------------ERQ--- 331

  Fly   455 DRRRERERDRQLEWERRNRNGAREPVTPTANTTPRPTNKPYPTVHRQHHHHNKPRKP--KPDSCM 517
                                             |||...|.         .::|..|  ||:.|.
  Rat   332 ---------------------------------PRPPRPPL---------GDRPSTPGAKPNICD 354

  Fly   518 TYYDAISIIRGELFIFRGPYLWRIGTSGLYNGYPTEIRRHWSALPENLTKVDAVYENKQRQIVFF 582
            ..::.:::.|||:|:|:..:.||:..:.:..|||.:|.:.|..||   .::||.||....:.|||
  Rat   355 GNFNTVALFRGEMFVFKDRWFWRLRNNRVQEGYPMQIEQFWKGLP---ARIDAAYERADGRFVFF 416

  Fly   583 IGREYYVFNSVMLAPGFPKPLASLGLPPTLTHIDASFVWGHNNRTYMTSGTLYWRIDDYTGQVEL 647
            .|.:|:||..|.:.||:|..|..||.......||.:..|....:||...|..|||..:.....:.
  Rat   417 KGDKYWVFKEVTVEPGYPHSLGELGSCLPREGIDTALRWEPVGKTYFFKGERYWRYSEERRATDP 481

  Fly   648 DYPRDMSIWSGVGYNIDAAFQYLDG-KTYFFKNLGYWEFNDDRMKVAHARAKLSARRWMQCARSA 711
            .||:.:::|.|:......||...:| .|||:|...||:|::.::.|.....:...|.||.|.:..
  Rat   482 GYPKPITVWKGIPQAPQGAFISKEGYYTYFYKGRDYWKFDNQKLSVEPGYPRNILRDWMGCKQKE 546

  Fly   712 NEVDDEQR 719
            .|...|:|
  Rat   547 VERRKERR 554

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mmp2	NP_995788.1	PG_binding_1	52..103	CDD:460223	16/50 (32%)
		Peptidase_M10	143..301	CDD:425668	74/167 (44%)
		HX	513..707	CDD:238046	61/194 (31%)
Mmp24	NP_113945.1	PG_binding_1	55..107	CDD:460223	16/51 (31%)
		Cysteine switch. /evidence=ECO:0000250	110..117		6/18 (33%)
		Peptidase_M10	135..300	CDD:425668	74/167 (44%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	296..352		24/219 (11%)
		HX	350..542	CDD:238046	61/194 (31%)
		Hemopexin 1	350..398		14/47 (30%)
		Hemopexin 2	399..444		19/47 (40%)
		Hemopexin 3	446..494		13/47 (28%)
		Hemopexin 4	495..542		14/46 (30%)
		DUF3377	548..618	CDD:463374	3/7 (43%)
		PDZ-binding	616..618