DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Mmp2 and Mmp14

DIOPT Version :9

Sequence 1:NP_995788.1 Gene:Mmp2 / 35997 FlyBaseID:FBgn0033438 Length:758 Species:Drosophila melanogaster
Sequence 2:NP_112318.1 Gene:Mmp14 / 81707 RGDID:620198 Length:582 Species:Rattus norvegicus


Alignment Length:718 Identity:200/718 - (27%)
Similarity:296/718 - (41%) Gaps:221/718 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly    53 YLMQFDYLPKSDLETGALRTEDQLKEAIRSLQSFGNITVTGEIDSATARLIQKPRCGVGDRRSAD 117
            :|.|:.|||..||.|...|:...|..||.::|.|..:.|||:.||.|.:.:::|||||       
  Rat    38 WLQQYGYLPPGDLRTHTQRSPQSLSAAIAAMQRFYGLQVTGKADSDTMKAMRRPRCGV------- 95

  Fly   118 SFSPDNLYHEIGSNVRVRRFALQGPKWSRTDLTWSMVNRSMPDASKVE--RMVQTALDVWANHSK 180
               ||....||.:|||.:|:|:||.||...::|:.:.|.: |...:..  ..::.|..||.:.:.
  Rat    96 ---PDKFGTEIKANVRRKRYAIQGLKWQHNEITFCIQNYT-PKVGEYATFEAIRKAFRVWESATP 156

  Fly   181 LTFREV--------YSDQADIQILFARRAHGDGYKFDGPGQVLAHAFYPGEGRGGDAHFDADETW 237
            |.||||        :..||||.||||...|||...|||.|..||||::||...|||.|||:.|.|
  Rat   157 LRFREVPYAYIREGHEKQADIMILFAEGFHGDSTPFDGEGGFLAHAYFPGPNIGGDTHFDSAEPW 221

  Fly   238 NFDGESDDSHGTNFLNVALHELGHSLGLAHSAIPDAVMFPWYQ----NNEVAGNLPDDDRYGIQQ 298
            ..  :::|.:|.:...||:|||||:|||.||..|.|:|.|:||    .|.|   ||||||.||||
  Rat   222 TV--QNEDLNGNDIFLVAVHELGHALGLEHSNDPSAIMAPFYQWMDTENFV---LPDDDRRGIQQ 281

  Fly   299 LYGTKEKTWGPYKPQTTTTTTTTTTMRAMIYRADKPAYWPWNNPSNNPNNDRNRARERQEEERRR 363
            |||:|.                                   .:|:..|                 
  Rat   282 LYGSKS-----------------------------------GSPTKMP----------------- 294

  Fly   364 QEKERRRQEEERRHQEEERRRQVEERQRQEEERWRQEQERQEEENRRRKIEHKSQWERNPSKERN 428
                                                                             
  Rat   295 ----------------------------------------------------------------- 294

  Fly   429 RPRERQEMERRRQEQERQEQERQEQEDRRRERERDRQLEWERRNRNGAREPVTPTANTTPRPTNK 493
                                                                 |...||.||:  
  Rat   295 -----------------------------------------------------PQPRTTSRPS-- 304

  Fly   494 PYPTVHRQHHHHNKPRKPK--PDSCMTYYDAISIIRGELFIFRGPYLWRIGTSGLYNGYPTEIRR 556
             .|         :|||.|.  |:.|...:|.::::|||:|:|:..:.||:..:.:.:|||..|.:
  Rat   305 -VP---------DKPRNPTYGPNICDGNFDTVAMLRGEMFVFKERWFWRVRNNQVMDGYPMPIGQ 359

  Fly   557 HWSALPENLTKVDAVYENKQRQIVFFIGREYYVFNSVMLAPGFPKPLASLGLPPTLTHIDASFVW 621
            .|..||   ..::..||.|..:.|||.|.:::||:...|.||:||.:..||.......|||:..|
  Rat   360 FWRGLP---ASINTAYERKDGKFVFFKGDKHWVFDEASLEPGYPKHIKELGRGLPTDKIDAALFW 421

  Fly   622 GHNNRTYMTSGTLYWRIDDYTGQVELDYPRDMSIWSGVGYNIDAAFQYLDGK-TYFFKNLGYWEF 685
            ..|.:||...|..|:|.::....|:.:||:::.:|.|:..:...:|...|.. |||:|...||:|
  Rat   422 MPNGKTYFFRGNKYYRFNEEFRAVDSEYPKNIKVWEGIPESPRGSFMGSDEVFTYFYKGNKYWKF 486

  Fly   686 NDDRMKVAHARAKLSARRWMQCARSANEVDDEQRWTASLVSEGEETGRSGSRELRINHFILSILL 750
            |:.::||.....|.:.|.||.|.......:..:..|..::.|.:|   .||..:.....:|.:||
  Rat   487 NNQKLKVEPGYPKSALRDWMGCPSGGRPDEGTEEETEVIIIEVDE---EGSGAVSAAAVVLPVLL 548

  Fly   751 LAI 753
            |.:
  Rat   549 LLL 551

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Mmp2NP_995788.1 Peptidase_M10 143..301 CDD:278824 75/171 (44%)
ZnMc_MMP 143..301 CDD:239805 75/171 (44%)
HX 513..707 CDD:238046 64/194 (33%)
Mmp14NP_112318.1 PG_binding_1 36..88 CDD:396175 20/49 (41%)
Cysteine switch. /evidence=ECO:0000250 91..98 6/16 (38%)
Peptidase_M10 118..284 CDD:395334 75/171 (44%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 280..317 18/218 (8%)
HX 316..508 CDD:238046 64/194 (33%)
Hemopexin 1 316..364 15/47 (32%)
Hemopexin 2 365..410 17/47 (36%)
Hemopexin 3 412..460 15/47 (32%)
Hemopexin 4 461..508 16/46 (35%)
DUF3377 <560..582 CDD:403153
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 148 1.000 Domainoid score I4331
eggNOG 1 0.900 - - E1_KOG1565
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1075463at2759
OrthoFinder 1 1.000 - - FOG0000840
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR10201
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X44
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
98.920

Return to query results.
Submit another query.