DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Mmp2 and Mmp2

DIOPT Version :9

Sequence 1:NP_995788.1 Gene:Mmp2 / 35997 FlyBaseID:FBgn0033438 Length:758 Species:Drosophila melanogaster
Sequence 2:NP_112316.2 Gene:Mmp2 / 81686 RGDID:621316 Length:662 Species:Rattus norvegicus


Alignment Length:783 Identity:186/783 - (23%)
Similarity:286/783 - (36%) Gaps:217/783 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 VLATLLALFAQSMCIQE--LSLPPEGSHSTAATRSKKAKTAISEDIMYNYLMQFDYLPKSDLETG 68
            ||..|..|...::....  :..|.:.|..|            .:::...||..|...||......
  Rat    16 VLCVLCCLLGHAIAAPSPIIKFPGDVSPKT------------DKELAVQYLNTFYGCPKESCNLF 68

  Fly    69 ALRTEDQLKEAIRSLQSFGNITVTGEIDSATARLIQKPRCGVGDRRSADSFSPDNLYHEIGSNVR 133
            .      ||:.::.:|.|..:..||::|..|...::|||||          :||         |.
  Rat    69 V------LKDTLKKMQKFFGLPQTGDLDQNTIETMRKPRCG----------NPD---------VA 108

  Fly   134 VRRFALQGPKWSRTDLTWSMVNRSMP-DASKVERMVQTALDVWANHSKLTFREVYSDQADIQILF 197
            ...|..:.|||.:..:|:.::..:.. |...|:.....||.||::.:.|.|..::..:|||.|.|
  Rat   109 NYNFFPRKPKWDKNQITYRIIGYTPDLDPETVDDAFARALKVWSDVTPLRFSRIHDGEADIMINF 173

  Fly   198 ARRAHGDGYKFDGPGQVLAHAFYPGEGRGGDAHFDADETW-------------NFDGESDD---- 245
            .|..|||||.|||...:|||||.||.|.|||:|||.||.|             |.|||...    
  Rat   174 GRWEHGDGYPFDGKDGLLAHAFAPGTGVGGDSHFDDDELWTLGEGQVVRVKYGNADGEYCKFPFL 238

  Fly   246 SHGTNFLNVALHELGHSLGLAHSAIPDAVMFPWYQNNEVAGNLPDDDRYGI---QQLY-----GT 302
            .:|..:.:..  :.|.|.|           |.|.....   |...|.:||.   :.|:     |.
  Rat   239 FNGREYSSCT--DTGRSDG-----------FLWCSTTY---NFEKDGKYGFCPHEALFTMGGNGD 287

  Fly   303 KEKTWGPYKPQTTTTTTTTTTMRAMIYR---------ADK--------------------PAYWP 338
            .:....|::.|.|:..:.||..|...||         .||                    |..:|
  Rat   288 GQPCKFPFRFQGTSYNSCTTEGRTDGYRWCGTTEDYDRDKKYGFCPETAMSTVGGNSEGAPCVFP 352

  Fly   339 WNNPSNNPNNDRNRARERQEEERRRQEKERRRQEEERRHQEEERRRQVEERQRQEEERWRQEQER 403
            :....|...:..:..|                        .:.:..........::.:|....::
  Rat   353 FTFLGNKYESCTSAGR------------------------SDGKVWCATTTNYDDDRKWGFCPDQ 393

  Fly   404 --------QEEENRRRKIEHKSQ----------WERNPSKERNRPRERQEMERRRQEQERQEQER 450
                    ..|......:||...          :.:|.....:..:..||:              
  Rat   394 GYSLFLVAAHEFGHAMGLEHSQDPGALMAPIYTYTKNFRLSNDDIKGIQEL-------------- 444

  Fly   451 QEQEDRRRERERDRQLEWERRNRNGAREPVTPTANTTPRPTNKPYPTVHRQHHHHNKPRKPKPDS 515
                                   .|..........|.|.||..|.                .|:.
  Rat   445 -----------------------YGPSPDADTDTGTGPTPTLGPV----------------TPEI 470

  Fly   516 CM--TYYDAISIIRGELFIFRGPYLWRIGTSGLYNGYPTEIRRHWSALPENLTKVDAVYENKQRQ 578
            |.  ..:|.|:.||||:|.|:..::||..|.......|..:...|..|||   |:|||||..|.:
  Rat   471 CKQDIVFDGIAQIRGEIFFFKDRFIWRTVTPRDKPTGPLLVATFWPELPE---KIDAVYEAPQEE 532

  Fly   579 -IVFFIGREYYVFNSVMLAPGFPKPLASLGLPPTLTHIDASFVWGHNNRTYMTSGTLYWRIDDYT 642
             .|||.|.||:|:::..|..|:||||.||||||.:..:||:|.|..|.:||:.||..:||.::..
  Rat   533 KAVFFAGNEYWVYSASTLERGYPKPLTSLGLPPDVQQVDAAFNWSKNKKTYIFSGDKFWRYNEVK 597

  Fly   643 GQVELDYPRDMS-IWSGVGYNIDAAFQYL-DGKTYFFKNLGYWEFNDDRMK-VAHARAKLSARRW 704
            .:::..:|:.:: .|:.:..|:||..... .|.:||||...|.:..:..:| |.....|..   |
  Rat   598 KKMDPGFPKLIADSWNAIPDNLDAVVDLQGGGHSYFFKGAYYLKLENQSLKSVKFGSIKSD---W 659

  Fly   705 MQC 707
            :.|
  Rat   660 LGC 662

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Mmp2NP_995788.1 Peptidase_M10 143..301 CDD:278824 57/183 (31%)
ZnMc_MMP 143..301 CDD:239805 57/183 (31%)
HX 513..707 CDD:238046 70/199 (35%)
Mmp2NP_112316.2 PG_binding_1 <70..97 CDD:396175 5/26 (19%)
Cysteine switch. /evidence=ECO:0000250 100..107 2/6 (33%)
Collagenase-like 1 110..221 34/111 (31%)
Peptidase_M10 118..446 CDD:395334 85/400 (21%)
Collagen-binding 222..396 47/227 (21%)
FN2 226..274 CDD:128373 23/64 (36%)
FN2 284..332 CDD:128373 11/55 (20%)
FN2 342..390 CDD:128373 6/67 (9%)
Collagenase-like 2 397..467 7/87 (8%)
Required for inhibitor TIMP2 binding. /evidence=ECO:0000250 414..662 68/260 (26%)
HX 468..662 CDD:238046 62/196 (32%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1565
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1075463at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR10201
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X44
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
65.920

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