DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mmp2 and VTN

DIOPT Version :9

Sequence 1:	NP_995788.1	Gene:	Mmp2 / 35997	FlyBaseID:	FBgn0033438	Length:	758	Species:	Drosophila melanogaster
Sequence 2:	NP_000629.3	Gene:	VTN / 7448	HGNCID:	12724	Length:	478	Species:	Homo sapiens

Alignment Length:	229	Identity:	60/229 - (26%)
Similarity:	86/229 - (37%)	Gaps:	72/229 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   474 NGAREPVTPTANTTPRP---TNKPYPTVHRQHHHHNKPRKPKP----DSCM-TYYDAISIIR-GE 529
            |..:.||.......|.|   .:||.....|....|  |.:|:|    :.|. ..:||.:.:: |.
Human   109 NPEQTPVLKPEEEAPAPEVGASKPEGIDSRPETLH--PGRPQPPAEEELCSGKPFDAFTDLKNGS 171

  Fly   530 LFIFRGPYLWRIGTSGLYNGYPTEIRRHWSALPENLTKVDAVYENKQRQIVFFIGREYYVFNSVM 594
            ||.|||.|.:.:....:..|||..||..|
Human   172 LFAFRGQYCYELDEKAVRPGYPKLIRDVW------------------------------------ 200

  Fly   595 LAPGFPKPLASLGLPPTLTHIDASFV-WGHNNRTYMTSGTLYWRIDDYTGQVELDYPRDMSI-WS 657
               |...|            |||:|. .....:||:..|:.|||.:|  |.::.||||::|. :.
Human   201 ---GIEGP------------IDAAFTRINCQGKTYLFKGSQYWRFED--GVLDPDYPRNISDGFD 248

  Fly   658 GVGYNIDAAF----QYLDG--KTYFFKNLGYWEF 685
            |:..|:|||.    ....|  :.||||...|||:
Human   249 GIPDNVDAALALPAHSYSGRERVYFFKGKQYWEY 282

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mmp2	NP_995788.1	Peptidase_M10	143..301	CDD:278824
		ZnMc_MMP	143..301	CDD:239805
		HX	513..707	CDD:238046	49/187 (26%)
VTN	NP_000629.3	SO	20..62	CDD:197571
		Cell attachment site	64..66
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	91..158		13/50 (26%)
		HX	154..472	CDD:238046	48/182 (26%)
		Hemopexin 1	158..202		15/82 (18%)
		Hemopexin 2	203..250		18/60 (30%)
		Hemopexin 3	251..305		12/32 (38%)
		Heparin-binding	362..395
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	364..398
		Hemopexin 4	419..472
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1565
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810