DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mmp2 and Mmp16

DIOPT Version :9

Sequence 1:	NP_995788.1	Gene:	Mmp2 / 35997	FlyBaseID:	FBgn0033438	Length:	758	Species:	Drosophila melanogaster
Sequence 2:	NP_542954.2	Gene:	Mmp16 / 65205	RGDID:	620199	Length:	607	Species:	Rattus norvegicus

Alignment Length:	671	Identity:	195/671 - (29%)
Similarity:	287/671 - (42%)	Gaps:	200/671 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 YLMQFDYLPKSDLETGALRTEDQLKEAIRSLQSFGNITVTGEIDSATARLIQKPRCGVGDR-RSA 116
            :|.::.|||.:|.....||:.:.::.|:.::|.|..|.:||::|..|...::||||||.|: |.:
  Rat    46 WLQKYGYLPPTDPRMSVLRSAETMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCGVPDQTRGS 110

  Fly   117 DSFSPDNLYHEIGSNVRVRRFALQGPKWSRTDLTWSMVNRSMPDASKVE--RMVQTALDVWANHS 179
            ..|           |:|.:|:||.|.||....:|:|:.|.: |.....|  |.::.|.|||.|.:
  Rat   111 SKF-----------NIRRKRYALTGQKWQHKHITYSIKNVT-PKVGDPETRRAIRRAFDVWQNVT 163

  Fly   180 KLTFREV-YSD------QADIQILFARRAHGDGYKFDGPGQVLAHAFYPGEGRGGDAHFDADETW 237
            .|||.|| ||:      ..||.|:||...|||...|||.|..||||::||.|.|||.|||:||.|
  Rat   164 PLTFEEVPYSELENGKRDVDITIIFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPW 228

  Fly   238 NFDGESDDSHGTNFLNVALHELGHSLGLAHSAIPDAVMFPWYQNNEVAG-NLPDDDRYGIQQLYG 301
            .....:.|  |.:...||:|||||:|||.||..|.|:|.|:||..|... .||:||..|||::||
  Rat   229 TLGNPNHD--GNDLFLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFKLPNDDLQGIQKIYG 291

  Fly   302 TKEKTWGPYKPQTTTTTTTTTTMRAMIYRADKPAYWPWNNPSNNPNNDRNRARERQEEERRRQEK 366
            ..:|...|.:|..|...          :|:..||     :|..|
  Rat   292 PPDKIPPPTRPLPTVPP----------HRSVPPA-----DPRKN--------------------- 320

  Fly   367 ERRRQEEERRHQEEERRRQVEERQRQEEERWRQEQERQEEENRRRKIEHKSQWERNPSKERNRPR 431
                                                                         :||:
  Rat   321 -------------------------------------------------------------DRPK 324

  Fly   432 ERQEMERRRQEQERQEQERQEQEDRRRERERDRQLEWERRNRNGAREPVTPTANTTPRPTNKP-Y 495
                                                           |..|       ||.:| |
  Rat   325 -----------------------------------------------PPRP-------PTGRPSY 335

  Fly   496 PTVHRQHHHHNKPRKPKPDSCMTYYDAISIIRGELFIFRGPYLWRIGTSGLYNGYPTEIRRHWSA 560
            |..             ||:.|...::.::|:|.|:|:|:..:.||:..:.:.:|||.:|...|..
  Rat   336 PGA-------------KPNICDGNFNTLAILRREMFVFKDQWFWRVRNNRVMDGYPMQITYFWRG 387

  Fly   561 LPENLTKVDAVYENKQRQIVFFIGREYYVFNSVMLAPGFPKPLASL--GLPPTLTH-IDASFVWG 622
            ||.:   :||||||.....|||.|.:|:||....|.||:|..|.:|  |:||   | ||::..|.
  Rat   388 LPPS---IDAVYENSDGNFVFFKGNKYWVFKDTTLQPGYPHDLITLGNGIPP---HGIDSAIWWE 446

  Fly   623 HNNRTYMTSGTLYWRIDDYTGQVELDYPRDMSIWSGVGYNIDAAFQYLD-GKTYFFKNLGYWEFN 686
            ...:||...|..|||..:....::..||:.::||.|:..:...||.:.: |.|||:|...||:||
  Rat   447 DVGKTYFFKGDRYWRYSEEMKTMDPGYPKPITIWKGIPESPQGAFVHKENGFTYFYKGKEYWKFN 511

  Fly   687 DDRMKVAHARAKLSARRWMQC 707
            :..:||.....:...:.:|.|
  Rat   512 NQILKVEPGYPRSILKDFMGC 532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mmp2	NP_995788.1	Peptidase_M10	143..301	CDD:278824	76/167 (46%)
		ZnMc_MMP	143..301	CDD:239805	76/167 (46%)
		HX	513..707	CDD:238046	67/197 (34%)
Mmp16	NP_542954.2	PG_binding_1	46..96	CDD:396175	15/49 (31%)
		Cysteine switch. /evidence=ECO:0000250	99..106		5/6 (83%)
		Peptidase_M10	126..291	CDD:395334	76/167 (46%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	281..340		25/222 (11%)
		PHA03247	<292..338	CDD:223021	18/196 (9%)
		HX	340..532	CDD:238046	67/197 (34%)
		Hemopexin 1	340..388		14/47 (30%)
		Hemopexin 2	389..434		20/47 (43%)
		Hemopexin 3	436..484		16/50 (32%)
		Hemopexin 4	485..532		14/46 (30%)
		DUF3377	537..607	CDD:403153
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	148	1.000	Domainoid score	I4331
eggNOG	1	0.900	-	-		E1_KOG1565
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1075463at2759
OrthoFinder	1	1.000	-	-		FOG0000840
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10201
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X44
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.920