DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mmp2 and MMP25

DIOPT Version :9

Sequence 1:NP_995788.1 Gene:Mmp2 / 35997 FlyBaseID:FBgn0033438 Length:758 Species:Drosophila melanogaster
Sequence 2:NP_071913.1 Gene:MMP25 / 64386 HGNCID:14246 Length:562 Species:Homo sapiens


Alignment Length:759 Identity:212/759 - (27%)
Similarity:291/759 - (38%) Gaps:258/759 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 VLATLLALFAQSMCIQELSLPPEGSHSTAATRSKKAKTAISEDIM--YNYLMQFDYLPKSDLETG 68
            :||.||.|.|          ||           .:|....::|:.  .::|.::.|||.......
Human     7 LLALLLLLLA----------PP-----------ARAPKPSAQDVSLGVDWLTRYGYLPPPHPAQA 50

  Fly    69 ALRTEDQLKEAIRSLQSFGNITVTGEIDSATARLIQKPRCGVGDRRSADSFSPDNLYHEIGSNVR 133
            .|::.::|::||:.:|.|..:..||.:|..|...::||||.:          ||.| ...|...|
Human    51 QLQSPEKLRDAIKVMQRFAGLPETGRMDPGTVATMRKPRCSL----------PDVL-GVAGLVRR 104

  Fly   134 VRRFALQGPKWSRTDLTWSMVNRSMPDASKVER-----MVQTALDVWANHSKLTFREVYSDQA-- 191
            .||:||.|..|.:..|||.:  ||.|.:|::.:     ::..||..|...|.|||.||.|.|.  
Human   105 RRRYALSGSVWKKRTLTWRV--RSFPQSSQLSQETVRVLMSYALMAWGMESGLTFHEVDSPQGQE 167

  Fly   192 -DIQILFARRAHGDGYKFDGPGQVLAHAFYPGEGR-GGDAHFDADETWNFDGESDDSHGTNFLNV 254
             ||.|.|||..|.|.|.|||.|..|||||:|||.. .||.|||.:|||.|.  |.|..||:...|
Human   168 PDILIDFARAFHQDSYPFDGLGGTLAHAFFPGEHPISGDTHFDDEETWTFG--SKDGEGTDLFAV 230

  Fly   255 ALHELGHSLGLAHSAIPDAVMFPWYQNNEVAGN-----LPDDDRYGIQQLYGTKEKTWGPYKPQT 314
            |:||.||:|||.||:.|:::|.|:||.  ..|:     |..|||.|:|||||...:|  ||    
Human   231 AVHEFGHALGLGHSSAPNSIMRPFYQG--PVGDPDKYRLSQDDRDGLQQLYGKAPQT--PY---- 287

  Fly   315 TTTTTTTTTMRAMIYRADKPAYWPWNNPSNNPNNDRNRARERQEEERRRQEKERRRQEEERRHQE 379
                             |||                                             
Human   288 -----------------DKP--------------------------------------------- 290

  Fly   380 EERRRQVEERQRQEEERWRQEQERQEEENRRRKIEHKSQWERNPSKERNRPRERQEMERRRQEQE 444
                                                                             
Human   291 ----------------------------------------------------------------- 290

  Fly   445 RQEQERQEQEDRRRERERDRQLEWERRNRNGAREPVTPTANTTPRPTNKPYPTVHRQHHHHNKPR 509
                                           .|:|:.|    .|:|...|          .:.|.
Human   291 -------------------------------TRKPLAP----PPQPPASP----------THSPS 310

  Fly   510 KPKPDSCMTYYDAISIIRGELFIFRGPYLWRIGTSG-LYNGYPTEIRRHWSALPENLTKVDAVY- 572
            .|.||.|...:|||:.||||.|.|:||:.||:..|| |.:..|..:.|.|..||..:..|.|.| 
Human   311 FPIPDRCEGNFDAIANIRGETFFFKGPWFWRLQPSGQLVSPRPARLHRFWEGLPAQVRVVQAAYA 375

  Fly   573 ENKQRQIVFFIGREYYVFNSVMLAPGFPKPLASLGLPPTLTHIDASFVWGHNNRTYMTSGTLYWR 637
            .::..:|:.|.|.:::||....|..| .:||..|||||. ..:||.|.|..|.:||:..|..|||
Human   376 RHRDGRILLFSGPQFWVFQDRQLEGG-ARPLTELGLPPG-EEVDAVFSWPQNGKTYLVRGRQYWR 438

  Fly   638 IDDYTGQVELDYPRDMSIWSGVGYNIDAAFQYLDGKTYFFKNLGYWEFNDDRMKVAHARAKLSAR 702
            .|:...:.:..||||:|:|.|...:.|.......|.|||||...||.|..:.:|......:....
Human   439 YDEAAARPDPGYPRDLSLWEGAPPSPDDVTVSNAGDTYFFKGAHYWRFPKNSIKTEPDAPQPMGP 503

  Fly   703 RWMQC--------------ARSANEVDDEQ--------RWTASL 724
            .|:.|              |...:|..|.|        ||.|.:
Human   504 NWLDCPAPSSGPRAPRPPKATPVSETCDCQCELNQAAGRWPAPI 547

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Mmp2NP_995788.1 Peptidase_M10 143..301 CDD:278824 78/171 (46%)
ZnMc_MMP 143..301 CDD:239805 78/171 (46%)
HX 513..707 CDD:238046 72/195 (37%)
MMP25NP_071913.1 PG_binding_1 25..85 CDD:279773 15/59 (25%)
Cysteine switch. /evidence=ECO:0000250 88..95 4/16 (25%)
Peptidase_M10 115..280 CDD:278824 78/170 (46%)
ZnMc_MMP 115..280 CDD:239805 78/170 (46%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 278..313 16/212 (8%)
HX 314..508 CDD:238046 72/195 (37%)
Hemopexin 1 314..363 22/48 (46%)
Hemopexin 2 367..412 15/45 (33%)
Hemopexin 3 413..461 19/48 (40%)
Hemopexin 4 462..508 12/45 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 490..526 4/35 (11%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 49 1.000 Domainoid score I11824
eggNOG 1 0.900 - - E1_KOG1565
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1075463at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3504
SonicParanoid 1 1.000 - - X44
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
87.850

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