Protein Alignment Mmp2 and Mmp8

DIOPT Version :10

• Sequence 1: NP_995788.1
• Gene: Mmp2 / 35997
• FlyBaseID: FBgn0033438
• Length: 758
• Species: Drosophila melanogaster
• Sequence 2: NP_071557.2
• Gene: Mmp8 / 63849
• RGDID: 631408
• Length: 466
• Species: Rattus norvegicus
• Alignment Length: 716
• Identity: 189/716 - (26%)
• Similarity: 266/716 - (37%)
• Gaps: 269/716 - (37%)

  Fly     7 LATL-LALFAQSMCIQELSLPPEGSHSTAATRSKKAKTAISEDIMYNYLMQFDYLPKSDLETGAL 70
            |.|| ...|..:.....|.:|||  |    ...|..|||      .|||.:|.:||.:...:.
  Rat     4 LKTLPFLFFFHTQLATALPVPPE--H----LEEKNMKTA------ENYLRKFYHLPSNQFRSA-- 54

  Fly    71 RTEDQLKEAIRSLQSFGNITVTGEIDSATARLIQKPRCGVGDRRSADSFSPDNLYHEIGSNVRVR 135
            |....:.|.::.:|.|..:..||:.|:||..:::||||||.|  |.|
  Rat    55 RNATMIAEKLKEMQRFFGLPETGKPDAATIEIMEKPRCGVPD--SGD------------------ 99

  Fly   136 RFALQ--GPKWSRTDLTWSMVNRSMPDASK--VERMVQTALDVWANHSKLTFREVYSDQADIQIL 196
             |.|.  .|||:.|:||:.::|.: |..||  |:..::.|..:|:..|.|||.|....:|||.|.
  Rat   100 -FLLTPGSPKWTHTNLTYRIINHT-PQMSKAEVKTEIEKAFKIWSVPSTLTFTETLEGEADINIA 162

  Fly   197 FARRAHGDGYKFDGPGQVLAHAFYPGEGRGGDAHFDADETWNFDGESDDSHGTNFLNVALHELGH 261
            |..|.|||...||||..:|||||.||.|.|||||||::|||     :.||:..|...||.||.||
  Rat   163 FVSRDHGDNSPFDGPNGILAHAFQPGRGIGGDAHFDSEETW-----TQDSNNYNLFLVAAHEFGH 222

  Fly   262 SLGLAHSAIPDAVMFPWYQNNEVAG-NLPDDDRYGIQQLYGTKEKTWGPYKPQTTTTTTTTTTMR 325
            ||||:||..|.|:|:|.|...|.:. :||.||..|||.:||
  Rat   223 SLGLSHSTDPGALMYPNYAYREPSTYSLPQDDINGIQTIYG------------------------ 263

  Fly   326 AMIYRADKPAYWPWNNPSNNPNNDRNRARERQEEERRRQEKERRRQEEERRHQEEERRRQVEERQ 390
                            ||:|
  Rat   264 ----------------PSDN--------------------------------------------- 267

  Fly   391 RQEEERWRQEQERQEEENRRRKIEHKSQWERNPSKERNRPRERQEMERRRQEQERQEQERQEQED 455
                                                                             
  Rat   268 ----------------------------------------------------------------- 267

  Fly   456 RRRERERDRQLEWERRNRNGAREPVTPTANTTPRPTNKPYPTVHRQHHHHNKPRKPKPDSCMTY- 519
                                   ||.||..:|                         |.:|..:
  Rat   268 -----------------------PVQPTGPST-------------------------PTACDPHL 284

  Fly   520 -YDAISIIRGELFIFRGPYLWR----IGTSGLYNGYPTEIRRHWSALPENLTKVDAVYENKQRQI 579
             :||.:.:|||::.|:..|.||    :.|..|     ..|...|..||..|   .|.||:..|.:
  Rat   285 RFDAATTLRGEIYFFKDKYFWRRHPQLRTVDL-----NFISLFWPFLPNGL---QAAYEDFDRDL 341

  Fly   580 VF-FIGREYYVFNSVMLAPGFPKPLASLGLPPTLTHIDASFVWGHNNRTYMTSGTLYWRIDDYTG 643
            || |.||:|:..::..|..|:|:.:::.|.|.::..|||:.  .:|.:||.......||.|:...
  Rat   342 VFLFKGRQYWALSAYDLQQGYPRDISNYGFPRSVQAIDAAV--SYNGKTYFFVNNQCWRYDNQRR 404

  Fly   644 QVELDYPRDM-SIWSGVGYNIDAAFQYLDGKTYFFKNLGYWEFNDDRMKVAH-ARAKLSARRWMQ 706
            .::..||..: |::.|:...|||.||. |....||....|:.||....:|.. ||:.|    |:.
  Rat   405 SMDPGYPTSIASVFPGINCRIDAVFQQ-DSFFLFFSGPQYFAFNLVSRRVTRVARSNL----WLN 464

  Fly   707 C 707
            |
  Rat   465 C 465

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mmp2	NP_995788.1	PG_binding_1	52..103	CDD:460223	15/50 (30%)
		Peptidase_M10	143..301	CDD:425668	76/160 (48%)
		HX	513..707	CDD:238046	62/202 (31%)
Mmp8	NP_071557.2	PG_binding_1	32..87	CDD:460223	18/62 (29%)
		Cysteine switch. /evidence=ECO:0000250	90..97		6/8 (75%)
		Peptidase_M10	108..263	CDD:425668	76/160 (48%)
		HX	277..465	CDD:238046	62/202 (31%)
		Hemopexin 1	277..326		15/53 (28%)
		Hemopexin 2	327..373		16/48 (33%)
		Hemopexin 3	375..421		12/47 (26%)
		Hemopexin 4	422..465		16/47 (34%)