DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mmp2 and mmp13

DIOPT Version :9

Sequence 1:	NP_995788.1	Gene:	Mmp2 / 35997	FlyBaseID:	FBgn0033438	Length:	758	Species:	Drosophila melanogaster
Sequence 2:	NP_001027506.1	Gene:	mmp13 / 613098	XenbaseID:	XB-GENE-6540414	Length:	261	Species:	Xenopus tropicalis

Alignment Length:	304	Identity:	114/304 - (37%)
Similarity:	153/304 - (50%)	Gaps:	57/304 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 ATLLALFAQSMCIQELSLPPEGSHSTAATRSKKAKTAISEDIMYNYLMQF--DYLPKSDLETGAL 70
            |.:.|:.|.| ||..:..|...::.:.:.|                  ||  .||.|..|.|.
Frog     4 AIVFAILALS-CIHAMPAPITDNNISPSDR------------------QFAEGYLDKYYLMTA-- 47

  Fly    71 RTEDQLKEAIRSLQSFGNITVTGEIDSATARLIQKPRCGVGDRRSADSFSPDNLYHEIGSNVRVR 135
            ::::...|.|:.:|.|..::|||.:||.|..:::.||||:.|                     |.
Frog    48 KSKNTFAEKIKEMQKFFGMSVTGRLDSDTMAMMKTPRCGMPD---------------------VA 91

  Fly   136 RFALQGP---KWSRTDLTWSMVNRSMPD--ASKVERMVQTALDVWANHSKLTFREVYSDQADIQI 195
            .|. |.|   :|::|.||:.:||.: ||  .|.|:..::.|..||::.:.|.|..:.|.:|||.|
Frog    92 EFR-QFPGRQRWTKTQLTYRIVNYT-PDLPRSMVDEAIRLAFKVWSDVTPLKFTRISSRRADIMI 154

  Fly   196 LFARRAHGDGYKFDGPGQVLAHAFYPGEGRGGDAHFDADETWNFDGESDDSHGTNFLNVALHELG 260
            .|..|:|||...||||..||||||.||.|.|||||||.||.|     :..|.|.|...||.||.|
Frog   155 QFGARSHGDFIPFDGPNGVLAHAFAPGSGIGGDAHFDEDERW-----TSTSAGFNLFLVAAHEFG 214

  Fly   261 HSLGLAHSAIPDAVMFPWYQ-NNEVAGNLPDDDRYGIQQLYGTK 303
            |||||.||..|.|:|||.|: .|.....||.||..|||.:||.|
Frog   215 HSLGLDHSRDPRALMFPSYRYMNTRNFRLPQDDVNGIQSIYGRK 258

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mmp2	NP_995788.1	Peptidase_M10	143..301	CDD:278824	77/160 (48%)
		ZnMc_MMP	143..301	CDD:239805	77/160 (48%)
		HX	513..707	CDD:238046
mmp13	NP_001027506.1	PG_binding_1	30..80	CDD:396175	18/69 (26%)
mmp13	NP_001027506.1	Peptidase_M10	101..256	CDD:395334	77/160 (48%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	145	1.000	Domainoid score	I4538
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1075463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10201
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3504
SonicParanoid	1	1.000	-	-		X44
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.050