Protein Alignment Mmp2 and mmp14

DIOPT Version :10

• Sequence 1: NP_995788.1
• Gene: Mmp2 / 35997
• FlyBaseID: FBgn0033438
• Length: 758
• Species: Drosophila melanogaster
• Sequence 2: NP_001025559.1
• Gene: mmp14 / 594950
• XenbaseID: XB-GENE-485643
• Length: 578
• Species: Xenopus tropicalis
• Alignment Length: 761
• Identity: 217/761 - (28%)
• Similarity: 311/761 - (40%)
• Gaps: 234/761 - (30%)

  Fly     6 VLATLLALFAQSMCIQELSLPPEGSHSTAATRSKKAKTAISEDIMYNYLMQFDYLPKSDLETGAL 70
            |.|..:.||..|:|           .|::|..|.:|           :|.|:.|||..||.|..|
 Frog     4 VRAAWICLFLCSVC-----------SSSSAKFSPEA-----------WLQQYGYLPPGDLRTHTL 46

  Fly    71 RTEDQLKEAIRSLQSFGNITVTGEIDSATARLIQKPRCGVGDRRSADSFSPDNLYHEIGSNVRVR 135
            |:...:..||.::|.|..:.|||..||.|.|.:::|||||          ||....||.:|||.:
 Frog    47 RSPQSMNAAISAMQKFYGLKVTGSFDSETERAMKRPRCGV----------PDKFGAEIKANVRRK 101

  Fly   136 RFALQGPKWSRTDLTWSMVNRS--MPDASKVERMVQTALDVWANHSKLTFREV--------YSDQ 190
            |:|:||.||...|:|:.:.|.:  :.:.|..| .::.|..||.:.:.|.||||        |:..
 Frog   102 RYAIQGLKWQHKDITFCIQNYTPKIGEYSTYE-AIRRAFKVWESVTPLRFREVRYVDIKDGYTKH 165

  Fly   191 ADIQILFARRAHGDGYKFDGPGQVLAHAFYPGEGRGGDAHFDADETWNFDGESDDSHGTNFLNVA 255
            |||.:.||...|||...|||.|..||||::||.|.|||.|||:.|.|.  ..:||..|.:...||
 Frog   166 ADIMLFFAEGFHGDSTPFDGEGGFLAHAYFPGPGIGGDTHFDSAEPWT--ARNDDLDGNDLFLVA 228

  Fly   256 LHELGHSLGLAHSAIPDAVMFPWYQNNEVAG-NLPDDDRYGIQQLYGTKEKTWGPYKPQTTTTTT 319
            :|||||:|||.||..|.|:|.|:||..:... .||||||.|||||||
 Frog   229 VHELGHALGLEHSNDPSAIMAPFYQWMDTQNFQLPDDDRRGIQQLYG------------------ 275

  Fly   320 TTTTMRAMIYRADKPAYWPWNNPSNNPNNDRNRARERQEEERRRQEKERRRQEEERRHQEEERRR 384
                                      ||:...
 Frog   276 --------------------------PNHGEG--------------------------------- 281

  Fly   385 QVEERQRQEEERWRQEQERQEEENRRRKIEHKSQWERNPSKERNRPRERQEMERRRQEQERQEQE 449
                                                                             
 Frog   282 ----------------------------------------------------------------- 281

  Fly   450 RQEQEDRRRERERDRQLEWERRNRNGAREPVTPTANTTPRPTNKPYPT-VHRQHHHHNKPRKPK- 512
                                           .||  ..||||..|.|| ..|.....:.|..|.
 Frog   282 -------------------------------LPT--RAPRPTRAPRPTQTQRPDDTPHDPNPPTY 313

  Fly   513 -PDSCMTYYDAISIIRGELFIFRGPYLWRIGTSGLYNGYPTEIRRHWSALPENLTKVDAVYENKQ 576
             ||.|...:|.|:::|||:|:|:..:.||:....:.:|||..|.:.|..||   :.:::.||.|.
 Frog   314 GPDICQGNFDTIAMLRGEMFVFKERWFWRVRHKRVMDGYPMPIGQFWRGLP---SSINSAYERKD 375

  Fly   577 RQIVFFIGREYYVFNSVMLAPGFPKPLASLGLPPTLTHIDASFVWGHNNRTYMTSGTLYWRIDDY 641
            .:.|||.|.:::||:..:|.||:||.|..||.......|||:..|..|.:||...||.|:|.::.
 Frog   376 GKFVFFKGDKHWVFDEAILEPGYPKTLKELGRGLPSDRIDAALYWMPNGKTYFFRGTKYYRFNEE 440

  Fly   642 TGQVELDYPRDMSIWSGVGYNIDAAFQYLDGK-TYFFKNLGYWEFNDDRMKVAHARAKLSARRWM 705
            ...|:.|||:.:::|.|:..:|..||...||. |||:|...||:||:..:|......|.....||
 Frog   441 MRAVDPDYPKPVNVWEGIPDSIKGAFMGSDGAFTYFYKGNKYWKFNNQLLKTESGYPKSVLVDWM 505

  Fly   706 QCARSANEVDDEQRWTASLVSEGEETGRSGSRELRINHFILSILLL 751
            .|: :|.:.||:......::...|.:|...:..:     ::.:|||
 Frog   506 GCS-TARQPDDDVDREVVIIEVDEASGGVSAAAI-----VVPVLLL 545

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mmp2	NP_995788.1	PG_binding_1	52..103	CDD:460223	21/50 (42%)
		Peptidase_M10	143..301	CDD:425668	75/168 (45%)
		HX	513..707	CDD:238046	70/194 (36%)
mmp14	NP_001025559.1	PG_binding_1	27..79	CDD:460223	22/62 (35%)
		Peptidase_M10	109..275	CDD:425668	75/168 (45%)
		HX	315..507	CDD:238046	70/194 (36%)
		DUF3377	513..578	CDD:463374	7/38 (18%)