DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mmp2 and Hpx

DIOPT Version :9

Sequence 1:NP_995788.1 Gene:Mmp2 / 35997 FlyBaseID:FBgn0033438 Length:758 Species:Drosophila melanogaster
Sequence 2:NP_445770.1 Gene:Hpx / 58917 RGDID:62040 Length:460 Species:Rattus norvegicus


Alignment Length:358 Identity:89/358 - (24%)
Similarity:134/358 - (37%) Gaps:104/358 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   395 ERWRQEQERQEEENRRRK----IEHKSQWERNPSKERN-RPRERQE------------MERRRQE 442
            |||:......:...|...    |:....|...|.|:.| .|:..||            :|..|.|
  Rat    88 ERWKNPVTSVDAAFRGPDSVFLIKEDKVWVYPPEKKENGYPKLFQEESPGIPYPPDAAVECHRGE 152

  Fly   443 QERQ-----EQERQEQED--RRRERERD--------RQLEWERR------NRNGAREPVTPTANT 486
            .:.:     :..|:...|  .|.::||.        ..|.|..|      |:.....||  |...
  Rat   153 CQSEGVLFFQGNRKWFWDFATRTQKERSWPAVGNCTAALRWLERYYCFQGNKFLRFNPV--TGEV 215

  Fly   487 TPRPTNKPYPTVHRQH------HHHNKPRK---------PKPDSCMTYYDAISII---RGELFIF 533
            .||     ||...|.:      ..|.|.|.         |....|.......:::   ||..:.|
  Rat   216 PPR-----YPLDARDYFISCPGRGHGKLRNGTAHGNSTHPMHSRCNADPGLSALLSDHRGATYAF 275

  Fly   534 RGPYLWRIGTS--GLYNGYPTEIRRHWSALPENLTKVDAVYENKQRQIVFFI-GREYYVF----- 590
            .|.:.||:.:|  | ::.:|  |..||   |:..:.|||.:...::  |:.| |.:.|||     
  Rat   276 SGSHYWRLDSSRDG-WHSWP--IAHHW---PQGPSAVDAAFSWDEK--VYLIQGTQVYVFLTKGG 332

  Fly   591 NSVMLAPGFPKPL-ASLGLPP--TLTHIDASFVWGHNNRTYMTSGTLYWRIDDYTGQ----VELD 648
            |:  |..|:||.| ..||.||  :|..|||:|....:::.|:|||...|.:|..:|.    .||.
  Rat   333 NN--LVSGYPKRLEKELGSPPGISLDTIDAAFSCPGSSKLYVTSGRRLWWLDLKSGAQATWAELS 395

  Fly   649 YPRDMSIWSGVGYNIDAAFQYLDGKTYFFKNLG 681
            :|.:.                :||.....|:||
  Rat   396 WPHEK----------------VDGALCLEKSLG 412

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Mmp2NP_995788.1 Peptidase_M10 143..301 CDD:278824
ZnMc_MMP 143..301 CDD:239805
HX 513..707 CDD:238046 53/187 (28%)
HpxNP_445770.1 HX 52..230 CDD:238046 32/148 (22%)
Hemopexin 1 53..93 3/4 (75%)
Hemopexin 2 94..138 9/43 (21%)
Hemopexin 3 139..183 8/43 (19%)
Hemopexin 4 184..230 12/52 (23%)
Hemopexin 5 257..302 13/50 (26%)
HX 269..458 CDD:238046 52/170 (31%)
Hemopexin 6 303..350 17/50 (34%)
Hemopexin 7 355..394 12/38 (32%)
Hemopexin 8 398..448 5/31 (16%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1565
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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