Protein Alignment Mmp2 and Mmp19

DIOPT Version :9

• Sequence 1: NP_995788.1
• Gene: Mmp2 / 35997
• FlyBaseID: FBgn0033438
• Length: 758
• Species: Drosophila melanogaster
• Sequence 2: NP_067387.1
• Gene: Mmp19 / 58223
• MGIID: 1927899
• Length: 527
• Species: Mus musculus
• Alignment Length: 709
• Identity: 172/709 - (24%)
• Similarity: 256/709 - (36%)
• Gaps: 244/709 - (34%)

  Fly    36 TRSKKAKTAISEDIMYNYLMQFDYLPKSDLETGA--LRTEDQLKEAIRSLQSFGNITVTGEIDSA 98
            |.|.:|.....::.:.:||:|:.||.| .|| ||  .|.|| :.||:|:.|....:.::|::|.|
Mouse    15 TVSGRALGPTEKEAVLDYLLQYGYLQK-PLE-GADDFRLED-ITEALRTFQEASGLPISGQMDDA 76

  Fly    99 TARLIQKPRCGVGDRRSADSFSPDNLYHEIGSNVRVRRFALQGPKWSRTDLTWSMVN----RSMP 159
            |...:::||||:     .|.|:..:|           ::.|.| .|.:.:||:.:.|    .|:|
Mouse    77 TRARMKQPRCGL-----EDPFNQKSL-----------KYLLLG-HWRKKNLTFRIFNVPSTLSLP 124

  Fly   160 DASKVERMVQTALDVWANHSKLTFREVYSDQADIQILFARRAHGD-----GYKFDGPGQVLAHAF 219
               :|...:..|...|::.:.||||||.:..|||::.|    ||.     ...|||||:|||||.
Mouse   125 ---RVRAALHQAFKYWSSVAPLTFREVKAGWADIRLSF----HGRQSLYCSNTFDGPGKVLAHAD 182

  Fly   220 YPGEGRGGDAHFDADETWNFDGESDDSHGTNFLNVALHELGHSLGLAHSAIPDAVMFPWYQNNEV 284
            .|   ..|..|||.||.|.    .....|.|...:|.||:||:|||.||....|:|.|.|...:.
Mouse   183 IP---ELGSIHFDKDELWT----EGTYQGVNLRIIAAHEVGHALGLGHSRYTQALMAPVYAGYQP 240

  Fly   285 AGNLPDDDRYGIQQLYGTKEKTWGPYKPQTTTTTTTTTTMRAMIYRADKPAYWPWNNPSNNPNND 349
            ...|..||..|||.|||
Mouse   241 FFKLHPDDVAGIQALYG------------------------------------------------ 257

  Fly   350 RNRARERQEEERRRQEKERRRQEEERRHQEEERRRQVEERQRQEEERWRQEQERQEEENRRRKIE 414
                               :|..|.|..:||.....|
Mouse   258 -------------------KRSPETRDEEEETEMLTV---------------------------- 275

  Fly   415 HKSQWERNPSKERNRPRERQEMERRRQEQERQEQERQEQEDRRRERERDRQLEWERRNRNGAREP 479
                                                                           .|
Mouse   276 ---------------------------------------------------------------SP 277

  Fly   480 VTPTANTTPRPTNKPYPTVHRQHHHHNKPRKPKPDSCMTYYDAISI-IRGELFIFRGPYLWRIGT 543
            ||.                        || .|.|:.|....||:.: .||:.:.|:|.|:|.:..
Mouse   278 VTA------------------------KP-GPMPNPCSGEVDAMVLGPRGKTYAFKGDYVWTVTD 317

  Fly   544 SGLYNGYPTEIRRHWSALPENLTKVDAVYENKQRQIVFFIGREYYVFNSVMLAPGFPKPLASLGL 608
            ||  .|...:|...|..||.||..  |||..:.|:..||.|.:.:.:....::||||.....  :
Mouse   318 SG--PGPLFQISALWEGLPGNLDA--AVYSPRTRRTHFFKGNKVWRYVDFKMSPGFPMKFNR--V 376

  Fly   609 PPTLTHIDASFVWGHNNRTYMTSGTLYWRIDDYTGQVELDYPRDM-SIWSGVGYNIDAAFQYLDG 672
            .|.|   ||:..|..|.:.::..|:.||:.|:........||:.: .:::||.....||..:.||
Mouse   377 EPNL---DAALYWPVNQKVFLFKGSGYWQWDELARTDLSRYPKPIKELFTGVPDRPSAAMSWQDG 438

  Fly   673 KTYFFKNLGYWEFNDDRMKVAHARAKLSARRWMQCARSANEVDDEQRWTASLVSEGEET 731
            :.||||...||..| .:::||....: :...||.|   .::..|....|..:.....:|
Mouse   439 QVYFFKGKEYWRLN-QQLRVAKGYPR-NTTHWMHC---GSQTPDTNSSTGDVTPSTTDT 492

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mmp2	NP_995788.1	Peptidase_M10	143..301	CDD:278824	62/166 (37%)
		ZnMc_MMP	143..301	CDD:239805	62/166 (37%)
		HX	513..707	CDD:238046	59/195 (30%)
Mmp19	NP_067387.1	PG_binding_1	32..81	CDD:279773	21/51 (41%)
		Cysteine switch. /evidence=ECO:0000250	84..91		4/11 (36%)
		Peptidase_M10	104..257	CDD:278824	62/166 (37%)
		ZnMc_MMP	105..257	CDD:239805	62/165 (38%)
		HX	286..471	CDD:238046	59/195 (30%)
		Hemopexin 1	286..333		15/48 (31%)
		Hemopexin 2	334..372		14/39 (36%)
		Hemopexin 3	377..425		12/50 (24%)
		Hemopexin 4	426..471		15/46 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	473..500		3/20 (15%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1565
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1075463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10201
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X44
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.920