DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mmp2 and mmp16b

DIOPT Version :9

Sequence 1:	NP_995788.1	Gene:	Mmp2 / 35997	FlyBaseID:	FBgn0033438	Length:	758	Species:	Drosophila melanogaster
Sequence 2:	XP_009295076.1	Gene:	mmp16b / 572034	ZFINID:	ZDB-GENE-061009-22	Length:	618	Species:	Danio rerio

Alignment Length:	695	Identity:	193/695 - (27%)
Similarity:	280/695 - (40%)	Gaps:	203/695 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 YLMQFDYLPKSDLETGALRTEDQLKEAIRSLQSFGNITVTGEIDSATARLIQKPRCGVGDRRSAD 117
            :|.::.||..:.....|.|:...:..||.::|....:.:||.::..|...::||||||.|:..|.
Zfish    42 WLQKYGYLHPTPPNMAAQRSAQTMHSAIAAMQHKYGLNITGTLNKYTIDWMKKPRCGVPDQLKAG 106

  Fly   118 SFSPDNLYHEIGSNVRVRRFALQGPKWSRTDLTWSMVNRSMPDASKVER--MVQTALDVWANHSK 180
            |.|.           |.:|:||.|.||.|..:::|:.|.: |.....|.  .::.|.|||...:.
Zfish   107 SASR-----------RKKRYALTGQKWQREHISYSIKNVT-PKVGNQETHDAIRRAFDVWQGVTP 159

  Fly   181 LTFREV-YSD------QADIQILFARRAHGDGYKFDGPGQVLAHAFYPGEGRGGDAHFDADETW- 237
            |.|..| :.|      ..||.|:||...|||...|||.|..||||::||.|.|||.|||:||.|
Zfish   160 LRFEAVPFRDLDSGKRDVDITIIFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWT 224

  Fly   238 ----NFDGESDDSHGTNFLNVALHELGHSLGLAHSAIPDAVMFPWYQNNEVAG-NLPDDDRYGIQ 297
                |.|||.  :.|.:...||:|||||:|||.||:.|.|:|.|:||..:... .||.||..|||
Zfish   225 LGNPNHDGER--TAGNDLFLVAVHELGHALGLEHSSDPTAIMAPFYQYMDTESFKLPHDDLQGIQ 287

  Fly   298 QLYGTKEKTWGPYKPQTTTTTTTTTTMRAMIYRADKPAYWPWNNPSNNPNNDRNRARERQEEERR 362
            ::||...|     .||.|...||.|..|..:             ||
Zfish   288 KIYGPPNK-----NPQPTRLLTTATPPRLHL-------------PS------------------- 315

  Fly   363 RQEKERRRQEEERRHQEEERRRQVEERQRQEEERWRQEQERQEEENRRRKIEHKSQWERNPSKER 427
                      :.|:|                                                ||
Zfish   316 ----------DPRKH------------------------------------------------ER 322

  Fly   428 NRPRERQEMERRRQEQERQEQERQEQEDRRRERERDRQLEWERRNRNGAREPVTPTANTTPRPTN 492
            :||.                                                         ||..
Zfish   323 SRPH---------------------------------------------------------RPPQ 330

  Fly   493 KPYPTVHRQHHHHNKPRKP--KPDSCMTYYDAISIIRGELFIFRGPYLWRIGTSGLYNGYPTEIR 555
            |            |||..|  |||.|...::.::|:|.|||:|:..:.||:..:.:..|||.:|.
Zfish   331 K------------NKPSHPNSKPDICDGGFNTLAILRNELFVFKDQWFWRVRDNSVVPGYPMQIS 383

  Fly   556 RHWSALPENLTKVDAVYENKQRQIVFFIGREYYVFNSVMLAPGFPKPLASLGLPPTLTHIDASFV 620
            ..|..||   .|:||||||.:.:.|||.|..::||....|.|.:|:.::..|.......|:.:..
Zfish   384 YFWRGLP---PKIDAVYENSEGKFVFFKGNRFWVFKDTTLQPTYPQDISLFGSGMPTQSIETAVW 445

  Fly   621 WGHNNRTYMTSGTLYWRIDDYTGQVELDYPRDMSIWSGVGYNIDAAF-QYLDGKTYFFKNLGYWE 684
            |....:||...|..|||.::....::..||:.:::|.|:..:...|| ...:|.|||:|...||:
Zfish   446 WEDVAKTYFFKGDRYWRYNEDMRTMDPGYPQPITVWKGIPDSPQGAFVDKANGFTYFYKGKEYWK 510

  Fly   685 FNDDRMKVAHARAKLSARRWMQCARSANEVDDEQRWTASLVSEGE 729
            ||:.|::|.....:...|.:|.|.....:.|    |..|...|.|
Zfish   511 FNNQRLRVEPGYPRSILRDFMGCDGLPTDPD----WDWSPPQEEE 551

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mmp2	NP_995788.1	Peptidase_M10	143..301	CDD:278824	73/172 (42%)
		ZnMc_MMP	143..301	CDD:239805	73/172 (42%)
		HX	513..707	CDD:238046	62/194 (32%)
mmp16b	XP_009295076.1	PG_binding_1	39..92	CDD:279773	11/49 (22%)
		Peptidase_M10	121..291	CDD:278824	73/172 (42%)
		ZnMc_MMP	121..291	CDD:239805	73/172 (42%)
		HX	341..533	CDD:238046	62/194 (32%)
		DUF3377	549..618	CDD:288690	2/3 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1565
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1075463at2759
OrthoFinder	1	1.000	-	-		FOG0000840
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10201
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3504
SonicParanoid	1	1.000	-	-		X44
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.950