DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mmp2 and mmp24

DIOPT Version :9

Sequence 1:	NP_995788.1	Gene:	Mmp2 / 35997	FlyBaseID:	FBgn0033438	Length:	758	Species:	Drosophila melanogaster
Sequence 2:	XP_699803.4	Gene:	mmp24 / 571143	ZFINID:	ZDB-GENE-040724-262	Length:	606	Species:	Danio rerio

Alignment Length:	680	Identity:	185/680 - (27%)
Similarity:	273/680 - (40%)	Gaps:	188/680 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 IMYNYLMQFDYLPKSDLETGALRTEDQLKEAIRSLQSFGNITVTGEIDSATARLIQKPRCGVGDR 113
            |:..:|..:.||...|:.|..||:|..::.|:.::|.|..|.|||.:|..|...::||||||.|
Zfish    40 IVETWLKNYGYLLPHDIRTSDLRSEKAMQSAVAAMQRFYGIPVTGILDQTTIEWMRKPRCGVPD- 103

  Fly   114 RSADSFSPDNLYHEIGSNVRVRRFALQGPKWSRTDLTWSMVNRSMPDASK-VERMVQTALDVWAN 177
                       :..|....|.:|:||.|.||....:|:|:.|.:.....| .:|.::.|.|||..
Zfish   104 -----------HPHISRRRRNKRYALTGQKWRDKKITYSIHNFTPKVGEKDTQRAIRQAFDVWQT 157

  Fly   178 HSKLTFREV-YSD------QADIQILFARRAHGDGYKFDGPGQVLAHAFYPGEGRGGDAHFDADE 235
            .:.|:|:|| ||:      :|||.|.||...|||...|||.|..||||::||.|.|||.|||:||
Zfish   158 VTPLSFQEVAYSEIKNEGKEADIMIFFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDE 222

  Fly   236 TWNFDGESDDSHGTNFLNVALHELGHSLGLAHSAIPDAVMFPWYQNNEVAG-NLPDDDRYGIQQL 299
            .|.....:.|  |.:...||:|||||:|||.||:.|.|:|.|:||..|... .||.||..|||::
Zfish   223 PWTLGNANHD--GNDLFLVAVHELGHALGLEHSSDPSAIMAPFYQYMETHNFKLPLDDLQGIQKI 285

  Fly   300 YGTKEKTWGPYKPQTTTTTTTTTTMRAMIYRADKPAYWPWNNPSNNPNNDRNRARERQEEERRRQ 364
            ||.......|.:|..|.                         |:..|::
Zfish   286 YGIPTAMLEPTRPLPTF-------------------------PARRPHS---------------- 309

  Fly   365 EKERRRQEEERRHQEEERRRQVEERQRQEEERWRQEQERQEEENRRRKIEHKSQWERNPSKERNR 429
                   ..||:|:.:.|
Zfish   310 -------TSERKHERQSR----------------------------------------------- 320

  Fly   430 PRERQEMERRRQEQERQEQERQEQEDRRRERERDRQLEWERRNRNGAREPVTPTANTTPRPTNKP 494
                                                             |..|:|...|
Zfish   321 -------------------------------------------------PGRPSAGDRP------ 330

  Fly   495 YPTVHRQHHHHNKPRKPKPDSCMTYYDAISIIRGELFIFRGPYLWRIGTSGLYNGYPTEIRRHWS 559
                       :.|...||:.|...::.::..|.|:|:|:..:.||:..:.:..|||..|...|.
Zfish   331 -----------SSPGHGKPNICDGNFNTVAFFRREMFVFKDRWFWRLRNNKVQEGYPMLIDHFWK 384

  Fly   560 ALPENLTKVDAVYENKQRQIVFFIGREYYVFNSVMLAPGFPKPLASLGLPPTLTHIDASFVWGHN 624
            .||.   ::||.||....:.|||.|.:|::|..|...||:|..|..||.......||.:..|...
Zfish   385 GLPH---RIDAAYERSDGKFVFFKGDKYWIFKEVTAEPGYPHSLVELGSYLPSDGIDTALRWESV 446

  Fly   625 NRTYMTSGTLYWRIDDYTGQVELDYPRDMSIWSGVGYNIDAAFQYLDG-KTYFFKNLGYWEFNDD 688
            .:||...|..|||.::.....:..||:.:.||.|:......||...:| .|||:|...||:|::.
Zfish   447 GKTYFFKGDQYWRYNEEKRTTDPGYPKPIGIWKGIPDAPQGAFVSREGFYTYFYKGKDYWKFDNQ 511

  Fly   689 RMKVAHARAKLSARRWMQCARSANEVDDEQ 718
            ::.|.....|...:.||.|.:|..|.:.::
Zfish   512 KLTVEPGYPKSILKDWMGCDQSEVEKNKDR 541

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mmp2	NP_995788.1	Peptidase_M10	143..301	CDD:278824	74/166 (45%)
		ZnMc_MMP	143..301	CDD:239805	74/166 (45%)
		HX	513..707	CDD:238046	60/194 (31%)
mmp24	XP_699803.4	PG_binding_1	41..94	CDD:279773	17/52 (33%)
		Peptidase_M10	122..287	CDD:278824	74/166 (45%)
		ZnMc_MMP	122..287	CDD:239805	74/166 (45%)
		HX	338..530	CDD:238046	60/194 (31%)
		DUF3377	536..606	CDD:288690	1/6 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1565
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1075463at2759
OrthoFinder	1	1.000	-	-		FOG0000840
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10201
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3504
SonicParanoid	1	1.000	-	-		X44
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.950