DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mmp2 and mmp14b

DIOPT Version :10

Sequence 1:NP_995788.1 Gene:Mmp2 / 35997 FlyBaseID:FBgn0033438 Length:758 Species:Drosophila melanogaster
Sequence 2:NP_919395.1 Gene:mmp14b / 566945 ZFINID:ZDB-GENE-030901-2 Length:621 Species:Danio rerio


Alignment Length:721 Identity:206/721 - (28%)
Similarity:290/721 - (40%) Gaps:236/721 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly    30 SHSTAATRSKKAKTAISEDIMYNYLMQFDYLPKSDLETGALRTEDQLKEAIRSLQSFGNITVTGE 94
            :|.:::.:..|.:.         :|.|:.|||..||.|...|:...:..||.::|.|..:||||.
Zfish    17 AHRSSSKQDMKPEA---------WLQQYGYLPPGDLRTHTARSPQSVPSAIAAMQRFYGLTVTGN 72

  Fly    95 IDSATARLIQKPRCGVGDRRSADSFSPDNLYHEIGSNVRVRRFALQGPKWSRTDLTWSMVNRSMP 159
            :|:.|...:::|||||          ||....|:.||:|.:|:|:||.||.:.::|:.:.|.: |
Zfish    73 LDANTLEAMKRPRCGV----------PDKFGSELKSNLRKKRYAIQGLKWDKNEITFCIQNYT-P 126

  Fly   160 DASKVE--RMVQTALDVWANHSKLTFREV-YS-------DQADIQILFARRAHGDGYKFDGPGQV 214
            ...:.|  ..::.|..||.:.:.|.|||: ||       |.|||.:.||...|||...|||.|..
Zfish   127 KVGEYETFEAIRKAFKVWESVTPLRFREISYSDIRDKVVDFADIMLFFADGFHGDASPFDGEGGF 191

  Fly   215 LAHAFYPGEGRGGDAHFDADETWNFDGESDDSHGTNFLNVALHELGHSLGLAHSAIPDAVMFPWY 279
            ||||::||.|.|||.||||.|.|....:  |..|.:...||:|||||:||:.||..|.|:|.|:|
Zfish   192 LAHAYFPGNGIGGDTHFDAAEPWTIGNK--DLLGNDVFLVAVHELGHALGMEHSNDPSAIMAPFY 254

  Fly   280 QNNEVAG-NLPDDDRYGIQQLYGTKEKTWGPYKPQTTTTTTTTTTMRAMIYRADKPAYWPWNNPS 343
            |..|... .||||||.|||:|||                                        |.
Zfish   255 QWMETDHFVLPDDDRKGIQKLYG----------------------------------------PG 279

  Fly   344 NNPNNDRNRARERQEEERRRQEKERRRQEEERRHQEEERRRQVEERQRQEEERWRQEQERQEEEN 408
            :..:                                                             
Zfish   280 SGGH------------------------------------------------------------- 283

  Fly   409 RRRKIEHKSQWERNPSKERNRPRERQEMERRRQEQERQEQERQEQEDRRRERERDRQLEWERRNR 473
                                                                             
Zfish   284 ----------------------------------------------------------------- 283

  Fly   474 NGAREPVTPTANTTPRPTNKPYPTVHRQHHHHNKPRKPK--PDSCMTYYDAISIIRGELFIFRGP 536
              .|.||:|   .||..|  ||||.:|       |..|.  |:.|..::|.|.|.|||:|:|:|.
Zfish   284 --PRPPVSP---ETPHHT--PYPTPYR-------PGGPSYGPNICEGHFDTIGIFRGEMFVFKGK 334

  Fly   537 YLWRIGTSGLYNGYPTEIRRHWSALPENLTKVDAVYENKQRQIVFFIGREYYVFNSVMLAPGFPK 601
            :.||:..:.:...||..|...|..||   |.::|.||.:..:.|||.|..::||....|.||:||
Zfish   335 WFWRVRNNQVMENYPMPIGHFWRGLP---TDINAAYEREDGKFVFFKGDRHWVFTESNLEPGYPK 396

  Fly   602 PLASLGLPPTLTHIDASFVWGHNNRTYMTSGTLYWRIDDYTGQVELDYPRDMSIWSGVGYNIDAA 666
            .|..||.......:||:.::.....||...|..|:|.::.|..|:.|||:.:|.|.||..||.||
Zfish   397 VLGELGTGVPKDKLDAALLYTPTGYTYFFRGNKYYRYNEDTHSVDPDYPKPISKWQGVPDNIKAA 461

  Fly   667 FQYLD-GKTYFFKNLGYWEFNDDRMKVAHARAKLSARRWMQCARSANEVDDEQRWTASLVSEGEE 730
            |...| |.|||:|...||:||:..:||.....|.:.:.||.|.                 :|...
Zfish   462 FMSRDQGYTYFYKANKYWKFNNQLLKVEPGYPKSALKDWMGCP-----------------NEDSN 509

  Fly   731 TGRSGS 736
            ||..||
Zfish   510 TGGGGS 515

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Mmp2NP_995788.1 PG_binding_1 52..103 CDD:460223 19/50 (38%)
Peptidase_M10 143..301 CDD:425668 74/168 (44%)
HX 513..707 CDD:238046 73/194 (38%)
mmp14bNP_919395.1 PG_binding_1 29..81 CDD:460223 19/60 (32%)
Peptidase_M10 111..277 CDD:425668 74/168 (44%)
HX 311..503 CDD:238046 73/194 (38%)
DUF3377 563..621 CDD:463374
Blue background indicates that the domain is not in the aligned region.

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