DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mmp2 and mmp14b

DIOPT Version :9

Sequence 1:	NP_995788.1	Gene:	Mmp2 / 35997	FlyBaseID:	FBgn0033438	Length:	758	Species:	Drosophila melanogaster
Sequence 2:	NP_919395.1	Gene:	mmp14b / 566945	ZFINID:	ZDB-GENE-030901-2	Length:	621	Species:	Danio rerio

Alignment Length:	721	Identity:	206/721 - (28%)
Similarity:	290/721 - (40%)	Gaps:	236/721 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 SHSTAATRSKKAKTAISEDIMYNYLMQFDYLPKSDLETGALRTEDQLKEAIRSLQSFGNITVTGE 94
            :|.:::.:..|.:.         :|.|:.|||..||.|...|:...:..||.::|.|..:||||.
Zfish    17 AHRSSSKQDMKPEA---------WLQQYGYLPPGDLRTHTARSPQSVPSAIAAMQRFYGLTVTGN 72

  Fly    95 IDSATARLIQKPRCGVGDRRSADSFSPDNLYHEIGSNVRVRRFALQGPKWSRTDLTWSMVNRSMP 159
            :|:.|...:::|||||          ||....|:.||:|.:|:|:||.||.:.::|:.:.|.: |
Zfish    73 LDANTLEAMKRPRCGV----------PDKFGSELKSNLRKKRYAIQGLKWDKNEITFCIQNYT-P 126

  Fly   160 DASKVE--RMVQTALDVWANHSKLTFREV-YS-------DQADIQILFARRAHGDGYKFDGPGQV 214
            ...:.|  ..::.|..||.:.:.|.|||: ||       |.|||.:.||...|||...|||.|..
Zfish   127 KVGEYETFEAIRKAFKVWESVTPLRFREISYSDIRDKVVDFADIMLFFADGFHGDASPFDGEGGF 191

  Fly   215 LAHAFYPGEGRGGDAHFDADETWNFDGESDDSHGTNFLNVALHELGHSLGLAHSAIPDAVMFPWY 279
            ||||::||.|.|||.||||.|.|....:  |..|.:...||:|||||:||:.||..|.|:|.|:|
Zfish   192 LAHAYFPGNGIGGDTHFDAAEPWTIGNK--DLLGNDVFLVAVHELGHALGMEHSNDPSAIMAPFY 254

  Fly   280 QNNEVAG-NLPDDDRYGIQQLYGTKEKTWGPYKPQTTTTTTTTTTMRAMIYRADKPAYWPWNNPS 343
            |..|... .||||||.|||:|||                                        |.
Zfish   255 QWMETDHFVLPDDDRKGIQKLYG----------------------------------------PG 279

  Fly   344 NNPNNDRNRARERQEEERRRQEKERRRQEEERRHQEEERRRQVEERQRQEEERWRQEQERQEEEN 408
            :..:
Zfish   280 SGGH------------------------------------------------------------- 283

  Fly   409 RRRKIEHKSQWERNPSKERNRPRERQEMERRRQEQERQEQERQEQEDRRRERERDRQLEWERRNR 473

Zfish   284 ----------------------------------------------------------------- 283

  Fly   474 NGAREPVTPTANTTPRPTNKPYPTVHRQHHHHNKPRKPK--PDSCMTYYDAISIIRGELFIFRGP 536
              .|.||:|   .||..|  ||||.:|       |..|.  |:.|..::|.|.|.|||:|:|:|.
Zfish   284 --PRPPVSP---ETPHHT--PYPTPYR-------PGGPSYGPNICEGHFDTIGIFRGEMFVFKGK 334

  Fly   537 YLWRIGTSGLYNGYPTEIRRHWSALPENLTKVDAVYENKQRQIVFFIGREYYVFNSVMLAPGFPK 601
            :.||:..:.:...||..|...|..||   |.::|.||.:..:.|||.|..::||....|.||:||
Zfish   335 WFWRVRNNQVMENYPMPIGHFWRGLP---TDINAAYEREDGKFVFFKGDRHWVFTESNLEPGYPK 396

  Fly   602 PLASLGLPPTLTHIDASFVWGHNNRTYMTSGTLYWRIDDYTGQVELDYPRDMSIWSGVGYNIDAA 666
            .|..||.......:||:.::.....||...|..|:|.::.|..|:.|||:.:|.|.||..||.||
Zfish   397 VLGELGTGVPKDKLDAALLYTPTGYTYFFRGNKYYRYNEDTHSVDPDYPKPISKWQGVPDNIKAA 461

  Fly   667 FQYLD-GKTYFFKNLGYWEFNDDRMKVAHARAKLSARRWMQCARSANEVDDEQRWTASLVSEGEE 730
            |...| |.|||:|...||:||:..:||.....|.:.:.||.|.                 :|...
Zfish   462 FMSRDQGYTYFYKANKYWKFNNQLLKVEPGYPKSALKDWMGCP-----------------NEDSN 509

  Fly   731 TGRSGS 736
            ||..||
Zfish   510 TGGGGS 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mmp2	NP_995788.1	Peptidase_M10	143..301	CDD:278824	74/168 (44%)
		ZnMc_MMP	143..301	CDD:239805	74/168 (44%)
		HX	513..707	CDD:238046	73/194 (38%)
mmp14b	NP_919395.1	PG_binding_1	29..81	CDD:279773	19/60 (32%)
		Peptidase_M10	111..277	CDD:278824	74/168 (44%)
		ZnMc_MMP	111..277	CDD:239805	74/168 (44%)
		HX	311..503	CDD:238046	73/194 (38%)
		DUF3377	563..621	CDD:288690
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1565
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1075463at2759
OrthoFinder	1	1.000	-	-		FOG0000840
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10201
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3504
SonicParanoid	1	1.000	-	-		X44
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.950