DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mmp2 and mmp11b

DIOPT Version :9

Sequence 1:	NP_995788.1	Gene:	Mmp2 / 35997	FlyBaseID:	FBgn0033438	Length:	758	Species:	Drosophila melanogaster
Sequence 2:	XP_694153.4	Gene:	mmp11b / 565793	ZFINID:	ZDB-GENE-070817-2	Length:	506	Species:	Danio rerio

Alignment Length:	707	Identity:	195/707 - (27%)
Similarity:	272/707 - (38%)	Gaps:	252/707 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LLALFAQSMCIQELSLPPEGSHSTAATRSKKAKTAISEDIMYNYLMQFDYLPKSD---------- 64
            |.|||....||..|.:|...||.                          |.|.:|
Zfish     7 LSALFYCIACIHSLPVPDGNSHR--------------------------YRPAADWPQKTHHHGL 45

  Fly    65 LETGAL-RTEDQLKEAIRSLQSFGNITVTGEIDSATARLIQKPRCGVGDRRSADSFSPDNLY--- 125
            .:.|.| ..:|.|.|      .|.|     :......:...:|||||.|..|....|  :|:
Zfish    46 KKRGRLHHVQDTLNE------DFSN-----KRAQPHTQFWNRPRCGVPDYPSEKGGS--SLHFSA 97

  Fly   126 HE---IGSNVRVRRFALQGPKWSRTDLTWSMVN--RSMPDASKVERMVQTALDVWANHSKLTFRE 185
            |:   :|...|.:||.|...:|.:||||:.::.  |.| :..:|..:::.||..|::.:.|.|.|
Zfish    98 HKGGLLGGRHRRKRFDLFPGRWDKTDLTYKIIQSPRQM-NLERVRYVIREALRAWSDETPLNFTE 161

  Fly   186 VYSDQADIQILFARRAHGDGYKFDGPGQVLAHAFYPGEGRGGDAHFDADETWNFDGESDDSHGTN 250
            |.|.:|||...|.|.:|||...|||||.:|||||:|...|.|:.|||.||:|..    .:|.||:
Zfish   162 VLSGRADIMFDFYRYSHGDYLNFDGPGGILAHAFFPRTYREGEIHFDMDESWTL----GNSMGTD 222

  Fly   251 FLNVALHELGHSLGLAHSAIPDAVMFPWYQ-NNEVAGNLPDDDRYGIQQLYGTKEKTWGPYKPQT 314
            .|.||.||:||.|||.||.:|.|||.|:|. :|.|  .|.:||:.|||.|||:|
Zfish   223 LLQVATHEIGHVLGLQHSKVPGAVMAPFYTFSNPV--RLSEDDKRGIQALYGSK----------- 274

  Fly   315 TTTTTTTTTMRAMIYRADKPAYWPWNNPSNNPNNDRNRARERQEEERRRQEKERRRQEEERRHQE 379
                           |:|:..                :|.||
Zfish   275 ---------------RSDETV----------------KAAER----------------------- 285

  Fly   380 EERRRQVEERQRQEEERWRQEQERQEEENRRRKIEHKSQWERNPSKERNRP--RERQEMERRRQE 442
                                                             ||  .||.|::...
Zfish   286 -------------------------------------------------RPTFTERNEIDATF-- 299

  Fly   443 QERQEQERQEQEDRRRERERDRQLEWERRNRNGAREPVTPTANTTPRPTNKPYPTVHRQHHHHNK 507
                                                                :|.||
Zfish   300 ----------------------------------------------------FPPVH-------- 304

  Fly   508 PRKPKPDSCMTYYDAISIIRGELFIFRGPYLWRIGTSGLYNGYPTEIRRHWSALPENLTKVDAVY 572
            |....||:|.|.:||:|:||||||.|:..|:|||....|..|||....|||..:|:|   :||.:
Zfish   305 PNPSHPDACQTNFDAVSMIRGELFFFKSGYVWRIRDGKLQAGYPALASRHWRGIPDN---IDAAF 366

  Fly   573 ENKQRQIVFFIGREYYVFNSVMLAPGFPKPLASLGLPPTLTHIDASFVWGHN--NRTYMTSGTLY 635
            |:....|.||.|:.|:||::.....| |..:..|||  .:..|.|:.:||..  .:.|......|
Zfish   367 EDMSGNIWFFQGQNYWVFDAERQITG-PDSVQRLGL--LVNDIQAALMWGDTKAQKIYFFKKGSY 428

  Fly   636 WRIDDYTGQVELDYPRDMSIWSGVGYNIDAAFQYLDGKTYFFKNLGYWEFNDDRMKV 692
            ||.:....:||..:||.||.|.|:..:||||||...|..:|.:...||:|:...::|
Zfish   429 WRFNLKENRVESMHPRSMSDWRGIPSDIDAAFQDRFGFAHFLRGKQYWKFDPVEVRV 485

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mmp2	NP_995788.1	Peptidase_M10	143..301	CDD:278824	73/160 (46%)
		ZnMc_MMP	143..301	CDD:239805	73/160 (46%)
		HX	513..707	CDD:238046	70/182 (38%)
mmp11b	XP_694153.4	Peptidase_M10	118..272	CDD:278824	73/160 (46%)
		ZnMc_MMP	118..272	CDD:239805	73/160 (46%)
		HX	310..500	CDD:238046	70/182 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1565
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1075463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10201
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X44
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	6	5.880