DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mmp2 and MMP26

DIOPT Version :9

Sequence 1:	NP_995788.1	Gene:	Mmp2 / 35997	FlyBaseID:	FBgn0033438	Length:	758	Species:	Drosophila melanogaster
Sequence 2:	NP_068573.2	Gene:	MMP26 / 56547	HGNCID:	14249	Length:	261	Species:	Homo sapiens

Alignment Length:	284	Identity:	94/284 - (33%)
Similarity:	128/284 - (45%)	Gaps:	53/284 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 LPPEGSHSTAATRSKKAKTAISEDIMYNYLMQFDYLPKSDLETGALRTEDQLKEAIRSLQSFGNI 89
            :||...|.             ..|.:..|..|| :|.|.:.......|:.||      ||.| :.
Human    20 VPPAADHK-------------GWDFVEGYFHQF-FLTKKESPLLTQETQTQL------LQQF-HR 63

  Fly    90 TVTGEIDSATARLIQKPRCGVGDRRSADSFSPDNLYHEIGSNVRVRRFALQGPKWSRTDLTWSMV 154
            ..|..:|.....|:.:|.|||.| .|..|.||...                  ||::..||:.::
Human    64 NGTDLLDMQMHALLHQPHCGVPD-GSDTSISPGRC------------------KWNKHTLTYRII 109

  Fly   155 NRSMP---DASKVERMVQTALDVWANHSKLTFREVYSDQADIQILFARRAHGDGYKFDGPGQVLA 216
            |  .|   ..|.|:..:..|:.:|:|.:.|.|::|.:..|||::.|.:.||.||:.|||||.:|.
Human   110 N--YPHDMKPSAVKDSIYNAVSIWSNVTPLIFQQVQNGDADIKVSFWQWAHEDGWPFDGPGGILG 172

  Fly   217 HAFYPGEGRGGDAHFDADETWNFDGESDDSHGTNFLNVALHELGHSLGLAHSAIPDAVMFP--WY 279
            |||.|..|..|..|||.:|.|     |....|.|...||.||:||||||.||....::|:|  ||
Human   173 HAFLPNSGNPGVVHFDKNEHW-----SASDTGYNLFLVATHEIGHSLGLQHSGNQSSIMYPTYWY 232

  Fly   280 QNNEVAGNLPDDDRYGIQQLYGTK 303
            .:.... .|..||...||.|||.|
Human   233 HDPRTF-QLSADDIQRIQHLYGEK 255

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mmp2	NP_995788.1	Peptidase_M10	143..301	CDD:278824	64/162 (40%)
		ZnMc_MMP	143..301	CDD:239805	64/162 (40%)
		HX	513..707	CDD:238046
MMP26	NP_068573.2	Cysteine switch. /evidence=ECO:0000250	80..87		5/7 (71%)
MMP26	NP_068573.2	Peptidase_M10	98..253	CDD:306839	64/162 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1565
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1075463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10201
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.920