Protein Alignment Mmp2 and MMP26

DIOPT Version :10

• Sequence 1: NP_995788.1
• Gene: Mmp2 / 35997
• FlyBaseID: FBgn0033438
• Length: 758
• Species: Drosophila melanogaster
• Sequence 2: NP_068573.2
• Gene: MMP26 / 56547
• HGNCID: 14249
• Length: 261
• Species: Homo sapiens
• Alignment Length: 283
• Identity: 94/283 - (33%)
• Similarity: 128/283 - (45%)
• Gaps: 51/283 - (18%)

  Fly    25 LPPEGSHSTAATRSKKAKTAISEDIMYNYLMQFDYLPKSDLETGALRTEDQLKEAIRSLQSFGNI 89
            :||...|.             ..|.:..|..|| :|.|.:.......|:.||      ||.| :.
Human    20 VPPAADHK-------------GWDFVEGYFHQF-FLTKKESPLLTQETQTQL------LQQF-HR 63

  Fly    90 TVTGEIDSATARLIQKPRCGVGDRRSADSFSPDNLYHEIGSNVRVRRFALQGPKWSRTDLTWSMV 154
            ..|..:|.....|:.:|.|||.| .|..|.||...                  ||::..||:.::
Human    64 NGTDLLDMQMHALLHQPHCGVPD-GSDTSISPGRC------------------KWNKHTLTYRII 109

  Fly   155 N--RSMPDASKVERMVQTALDVWANHSKLTFREVYSDQADIQILFARRAHGDGYKFDGPGQVLAH 217
            |  ..| ..|.|:..:..|:.:|:|.:.|.|::|.:..|||::.|.:.||.||:.|||||.:|.|
Human   110 NYPHDM-KPSAVKDSIYNAVSIWSNVTPLIFQQVQNGDADIKVSFWQWAHEDGWPFDGPGGILGH 173

  Fly   218 AFYPGEGRGGDAHFDADETWNFDGESDDSHGTNFLNVALHELGHSLGLAHSAIPDAVMFP--WYQ 280
            ||.|..|..|..|||.:|.|     |....|.|...||.||:||||||.||....::|:|  ||.
Human   174 AFLPNSGNPGVVHFDKNEHW-----SASDTGYNLFLVATHEIGHSLGLQHSGNQSSIMYPTYWYH 233

  Fly   281 NNEVAGNLPDDDRYGIQQLYGTK 303
            :.... .|..||...||.|||.|
Human   234 DPRTF-QLSADDIQRIQHLYGEK 255

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mmp2	NP_995788.1	PG_binding_1	52..103	CDD:460223	13/50 (26%)
		Peptidase_M10	143..301	CDD:425668	64/161 (40%)
		HX	513..707	CDD:238046
MMP26	NP_068573.2	Cysteine switch. /evidence=ECO:0000250	80..87		5/7 (71%)
		Peptidase_M10	98..253	CDD:425668	64/161 (40%)