DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mmp2 and mmp15a

DIOPT Version :9

Sequence 1:	NP_995788.1	Gene:	Mmp2 / 35997	FlyBaseID:	FBgn0033438	Length:	758	Species:	Drosophila melanogaster
Sequence 2:	XP_001924042.4	Gene:	mmp15a / 561041	ZFINID:	ZDB-GENE-070817-4	Length:	651	Species:	Danio rerio

Alignment Length:	683	Identity:	199/683 - (29%)
Similarity:	288/683 - (42%)	Gaps:	180/683 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 AKTAISEDIMYN---YLMQFDYLPKSDLETGALRTEDQLKEAIRSLQSFGNITVTGEIDSATARL 102
            |:|: :||..:|   :|..:.||.::..:...:::...|..|||.:|.|..:..||.:||.|.|.
Zfish    24 AETS-AEDEDFNAESWLRTYGYLSQASRQMSTMQSSQILSSAIRDMQRFYGLQETGHMDSETLRA 87

  Fly   103 IQKPRCGVGDRRSADSFSPDNLYHEIGSNVRVRRFALQGPKWSRTDLTWSMVNRSMPDASKVE-- 165
            :::|||||.|.....|          ....|.:||||.|.||::.:||:|:.|.| |...:.:
Zfish    88 MKRPRCGVADHFEESS----------EGAARRKRFALTGHKWNQNNLTYSIQNHS-PKVGQQQTY 141

  Fly   166 RMVQTALDVWANHSKLTFREV-Y------SDQADIQILFARRAHGDGYKFDGPGQVLAHAFYPGE 223
            ..::.|..||...:.|.|.|| |      |:..||.:|||...|||...|||.|..|||||:||.
Zfish   142 EAIRKAFRVWEKVTPLQFEEVPYHKIKNGSEGPDIILLFASGYHGDMSLFDGEGGSLAHAFFPGP 206

  Fly   224 GRGGDAHFDADETWNFDGESDDSHGTNFLNVALHELGHSLGLAHSAIPDAVMFPWYQNNEVAG-N 287
            |.|||.|||.||.|..:  ..:..|.:...||:|||||:|||.||..|.|:|.|:||..:... .
Zfish   207 GMGGDTHFDTDEPWTLN--QQEGSGVDLFLVAVHELGHALGLEHSNNPSAIMAPFYQWMDTESFA 269

  Fly   288 LPDDDRYGIQQLYGTKEKTWGPYKPQTTTTTTTTTTMRAMIYRADKPAYWPWNNPSNNPNNDRNR 352
            |.|||..||.|:||:.|.......|.||..|||.           ||      .|:..
Zfish   270 LADDDINGIHQIYGSPETVTTQAAPTTTLFTTTA-----------KP------EPTTT------- 310

  Fly   353 ARERQEEERRRQEKERRRQEEERRHQEEERRRQVEERQRQEEERWRQEQERQEEENRRRKIEHKS 417
                                                             |.|.:..|
Zfish   311 -------------------------------------------------EAQPKTTR-------- 318

  Fly   418 QWERNPSKERNRPRERQEMERRRQEQERQEQERQEQEDRRRERERDRQLEWERRNRNGAREPVTP 482
                 ||.:..||                                     |.        .||.|
Zfish   319 -----PSLQPTRP-------------------------------------WV--------PPVNP 333

  Fly   483 TANTTPRPTNKPYPTVHRQHHHHNKPRKPKPDSCMTYYDAISIIRGELFIFRGPYLWRIGTSGLY 547
            |     |.|.:|.||        ::..:..||.|...:|.::::|||:|:|:|.:.||:..:.:.
Zfish   334 T-----RRTYRPQPT--------SRSNQDAPDICEGNFDTVTMLRGEMFVFKGRWFWRVRRNRVL 385

  Fly   548 NGYPTEIRRHWSALPENLTKVDAVYENKQRQIVFFIGREYYVFNSVMLAPGFPKPL--ASLGLPP 610
            :.||..|...|..|||:   :||.||....:.|||.|.:|::|....:.||:|:.|  ...|:|
Zfish   386 DNYPMPISFFWMGLPED---IDAAYERHDGKFVFFKGSKYWLFREADVEPGYPQDLFRYGQGMP- 446

  Fly   611 TLTHIDASFVWGHNNRTYMTSGTLYWRIDDYTGQVELDYPRDMSIWSGVGYNIDAAFQYLDGK-T 674
              ..:|.:..|..:..||...|..|||..:.:..::.|||:.:|:|..:..:...||...||. |
Zfish   447 --ERVDTAVWWEPSGYTYFFRGDRYWRFSEESRAMDKDYPKPVSVWGSIPVSPKGAFLSDDGAYT 509

  Fly   675 YFFKNLGYWEFNDDRMKVAHARAKLSARRWMQC 707
            ||:|...||.|::.||||.....:.....:|.|
Zfish   510 YFYKGTKYWRFDNKRMKVDSGYPRSILNDFMGC 542

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mmp2	NP_995788.1	Peptidase_M10	143..301	CDD:278824	72/167 (43%)
		ZnMc_MMP	143..301	CDD:239805	72/167 (43%)
		HX	513..707	CDD:238046	64/196 (33%)
mmp15a	XP_001924042.4	PG_binding_1	34..88	CDD:279773	16/53 (30%)
		Peptidase_M10	118..283	CDD:278824	72/167 (43%)
		ZnMc_MMP	118..283	CDD:239805	72/167 (43%)
		HX	351..542	CDD:238046	64/196 (33%)
		DUF3377	589..651	CDD:288690
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1565
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1075463at2759
OrthoFinder	1	1.000	-	-		FOG0000840
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10201
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X44
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.920