Protein Alignment Mmp2 and mmp15a

DIOPT Version :10

• Sequence 1: NP_995788.1
• Gene: Mmp2 / 35997
• FlyBaseID: FBgn0033438
• Length: 758
• Species: Drosophila melanogaster
• Sequence 2: XP_001924042.5
• Gene: mmp15a / 561041
• ZFINID: ZDB-GENE-070817-4
• Length: 651
• Species: Danio rerio
• Alignment Length: 683
• Identity: 198/683 - (28%)
• Similarity: 288/683 - (42%)
• Gaps: 180/683 - (26%)

  Fly    41 AKTAISEDIMYN---YLMQFDYLPKSDLETGALRTEDQLKEAIRSLQSFGNITVTGEIDSATARL 102
            |:|: :||..:|   :|..:.||.::..:...:::...|..|||.:|.|..:..||.:||.|.|.
Zfish    24 AETS-AEDEDFNAESWLRTYGYLSQASRQMSTMQSSQILSSAIRDMQRFYGLQETGHMDSETLRA 87

  Fly   103 IQKPRCGVGDRRSADSFSPDNLYHEIGSNVRVRRFALQGPKWSRTDLTWSMVNRSMPDASKVE-- 165
            :::|||||.|.....|          ....|.:||||.|.||::.:||:|:.|.| |...:.:
Zfish    88 MKRPRCGVADHFEESS----------EGAARRKRFALTGHKWNQNNLTYSIQNHS-PKVGQQQTY 141

  Fly   166 RMVQTALDVWANHSKLTFREV-Y------SDQADIQILFARRAHGDGYKFDGPGQVLAHAFYPGE 223
            ..::.|..||...:.|.|.|: |      |:..||.:|||...|||...|||.|..|||||:||.
Zfish   142 EAIRKAFRVWEKVTPLQFEEIPYHKIKNGSEGPDIILLFASGYHGDMSLFDGEGGSLAHAFFPGP 206

  Fly   224 GRGGDAHFDADETWNFDGESDDSHGTNFLNVALHELGHSLGLAHSAIPDAVMFPWYQNNEVAG-N 287
            |.|||.|||.||.|..:  ..:..|.:...||:|||||:|||.||..|.|:|.|:||..:... .
Zfish   207 GMGGDTHFDTDEPWTLN--QQEGSGVDLFLVAVHELGHALGLEHSNNPSAIMAPFYQWMDTESFA 269

  Fly   288 LPDDDRYGIQQLYGTKEKTWGPYKPQTTTTTTTTTTMRAMIYRADKPAYWPWNNPSNNPNNDRNR 352
            |.|||..||.|:||:.|.......|.||..|||.           ||      .|:..
Zfish   270 LADDDINGIHQIYGSPETVTTQAAPTTTLFTTTA-----------KP------EPTTT------- 310

  Fly   353 ARERQEEERRRQEKERRRQEEERRHQEEERRRQVEERQRQEEERWRQEQERQEEENRRRKIEHKS 417
                                                             |.|.:..|
Zfish   311 -------------------------------------------------EAQPKTTR-------- 318

  Fly   418 QWERNPSKERNRPRERQEMERRRQEQERQEQERQEQEDRRRERERDRQLEWERRNRNGAREPVTP 482
                 ||.:..||                                     |        ..||.|
Zfish   319 -----PSLQPTRP-------------------------------------W--------MPPVNP 333

  Fly   483 TANTTPRPTNKPYPTVHRQHHHHNKPRKPKPDSCMTYYDAISIIRGELFIFRGPYLWRIGTSGLY 547
            |     |.|.:|.||        ::..:..||.|...:|.::::|||:|:|:|.:.||:..:.:.
Zfish   334 T-----RRTYRPQPT--------SRSNQDAPDICEGNFDTVTMLRGEMFVFKGRWFWRVRRNRVL 385

  Fly   548 NGYPTEIRRHWSALPENLTKVDAVYENKQRQIVFFIGREYYVFNSVMLAPGFPKPL--ASLGLPP 610
            :.||..|...|..|||:   :||.||....:.|||.|.:|::|....:.||:|:.|  ...|:|
Zfish   386 DNYPMPISFFWMGLPED---IDAAYERHDGKFVFFKGSKYWLFREADVEPGYPQDLFRYGQGMP- 446

  Fly   611 TLTHIDASFVWGHNNRTYMTSGTLYWRIDDYTGQVELDYPRDMSIWSGVGYNIDAAFQYLDGK-T 674
              ..:|.:..|..:..||...|..|||..:.:..::.|||:.:|:|..:..:...||...||. |
Zfish   447 --ERVDTAVWWEPSGYTYFFRGDRYWRFSEESRAMDKDYPKPVSVWGSIPVSPKGAFLSDDGAYT 509

  Fly   675 YFFKNLGYWEFNDDRMKVAHARAKLSARRWMQC 707
            ||:|...||.|::.||||.....:.....:|.|
Zfish   510 YFYKGTKYWRFDNKRMKVDSGYPRSILNDFMGC 542

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mmp2	NP_995788.1	PG_binding_1	52..103	CDD:460223	16/53 (30%)
		Peptidase_M10	143..301	CDD:425668	71/167 (43%)
		HX	513..707	CDD:238046	64/196 (33%)
mmp15a	XP_001924042.5	None