Protein Alignment Mmp2 and mmp15

DIOPT Version :9

• Sequence 1: NP_995788.1
• Gene: Mmp2 / 35997
• FlyBaseID: FBgn0033438
• Length: 758
• Species: Drosophila melanogaster
• Sequence 2: NP_001015921.1
• Gene: mmp15 / 548675
• XenbaseID: XB-GENE-1014388
• Length: 648
• Species: Xenopus tropicalis
• Alignment Length: 749
• Identity: 212/749 - (28%)
• Similarity: 295/749 - (39%)
• Gaps: 231/749 - (30%)

  Fly    53 YLMQFDYLPKSDLETGALRTEDQLKEAIRSLQSFGNITVTGEIDSATARLIQKPRCGVGDRRSAD 117
            :|..:.|||::..:...:|:...|..||..:|.|..|..|||:|..|...:|||||||
 Frog    48 WLKLYGYLPQTSRQMSTMRSLQILSSAISEMQRFYGIPETGELDHTTTEWMQKPRCGV------- 105

  Fly   118 SFSPDNLYHEIGSNVRVRRFALQGPKWSRTDLTWSMVNRS-------MPDASKVERMVQTALDVW 175
               ||.....:.||:|.:|:|..|.||::..||:|:.|.|       ..||      ::.|.|||
 Frog   106 ---PDQFGTRVKSNMRRKRYAHTGRKWNQQHLTYSIQNYSDKLGMHNSIDA------IRKAFDVW 161

  Fly   176 ANHSKLTFREV-YS------DQADIQILFARRAHGDGYKFDGPGQVLAHAFYPGEGRGGDAHFDA 233
            :..:.|||||| |.      ..|||.||||...|||...|||||..||||::||.|.|||||||:
 Frog   162 SKATSLTFREVPYEAVRQRHSSADILILFASGFHGDSSPFDGPGGFLAHAYFPGPGMGGDAHFDS 226

  Fly   234 DETWNFDGESDDSHGTNFLNVALHELGHSLGLAHSAIPDAVMFPWYQNNEVAG-NLPDDDRYGIQ 297
            :|.|..  |:.|..|.:...||:|||||||||.||..|.|:|.|:||..:... .||:|||.|||
 Frog   227 EEPWTV--ENMDLAGNHLFLVAVHELGHSLGLEHSNNPSAIMAPFYQWMDTEDFQLPEDDRRGIQ 289

  Fly   298 QLYGTKEKTWGPYKPQTTTTTTTTTTMRAMIYRADKPAYWPWNNPSNNPNNDRNRARERQEEERR 362
            |||       ||...|..:|.:...|
 Frog   290 QLY-------GPPVDQIPSTQSPLPT--------------------------------------- 308

  Fly   363 RQEKERRRQEEERRHQEEERRRQVEERQRQEEERWRQEQERQEEENRRRKIEHKSQWERNPSKER 427
                                                                        |.|
 Frog   309 ------------------------------------------------------------PGK-- 311

  Fly   428 NRPRERQEMERRRQEQERQEQERQEQEDRRRERERDRQLEWERRNRNGAREPVTPTANTTPRPTN 492
                                   .|..|:                    |.|..|......||.|
 Frog   312 -----------------------PEVPDK--------------------RPPKPPPRGKPERPGN 333

  Fly   493 KPYPTVHRQHHHHNKPRKPK---PDSCMTYYDAISIIRGELFIFRGPYLWRIGTSGLYNGYPTEI 554
            .|.|         ..|..|.   |:.|...:||:|::|||:|:|:|.:.||:..:.:.:.||..|
 Frog   334 APPP---------RSPSNPDQYGPNICEGNFDAVSVLRGEMFVFKGAWFWRVRHNRVLDNYPMPI 389

  Fly   555 RRHWSALPENLTKVDAVYENKQRQIVFFIGREYYVFNSVMLAPGFPKPLASLGLPPTLTHIDASF 619
            ...|..||.|:|   |.||....:.|||.|.:|::|....|..|:|:||.|.|.......||.:.
 Frog   390 GHFWRGLPPNIT---AAYERHDGKFVFFKGEKYWLFREANLEAGYPQPLTSFGYGIPYDRIDTAI 451

  Fly   620 VWGHNNRTYMTSGTLYWRIDDYTGQVELDYPRDMSIWSGVGYNIDAAFQYLDGK-TYFFKNLGYW 683
            .|.....||:..|..|||.::.:...::.||:.:::|:|:......||...|.. |||:|...||
 Frog   452 FWEPTGHTYLFRGDKYWRFNEESRSADVGYPKPITVWAGIPDTPKGAFLSSDSTYTYFYKGAKYW 516

  Fly   684 EFNDDRMKVAHARAKLSARRWMQCARSA-NEVDDEQRW---------------------TASLVS 726
            :|::.::|......|...|.:|.|.... .:.|...||                     :.|...
 Frog   517 KFDNQQLKTEPGYPKSILRDFMGCQEEVFQDPDVVPRWPDVEHPPFNPDVESEDKDDKDSDSAGR 581

  Fly   727 EGEETGRSGSRELRINHF---------ILSILLL 751
            |...|||.....:.|:.:         |:.:|||
 Frog   582 EDPNTGRDVDVVVHIDEYTRAVSVAMVIVPLLLL 615

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mmp2	NP_995788.1	Peptidase_M10	143..301	CDD:278824	83/172 (48%)
		ZnMc_MMP	143..301	CDD:239805	83/172 (48%)
		HX	513..707	CDD:238046	64/194 (33%)
mmp15	NP_001015921.1	PG_binding_1	45..98	CDD:366659	16/49 (33%)
		Peptidase_M10	128..293	CDD:334067	84/179 (47%)
		HX	348..540	CDD:238046	64/194 (33%)
		DUF3377	579..648	CDD:371766	9/37 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	145	1.000	Domainoid score	I4538
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1075463at2759
OrthoFinder	1	1.000	-	-		FOG0000840
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10201
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3504
SonicParanoid	1	1.000	-	-		X44
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	9.050