DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mmp2 and MMP19

DIOPT Version :9

Sequence 1:	NP_995788.1	Gene:	Mmp2 / 35997	FlyBaseID:	FBgn0033438	Length:	758	Species:	Drosophila melanogaster
Sequence 2:	NP_002420.1	Gene:	MMP19 / 4327	HGNCID:	7165	Length:	508	Species:	Homo sapiens

Alignment Length:	668	Identity:	162/668 - (24%)
Similarity:	246/668 - (36%)	Gaps:	223/668 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 ISEDIMYNYLMQFDYLPKSDLETGALRTEDQLKEAIRSLQSFGNITVTGEIDSATARLIQKPRCG 109
            ::|....:||.|:.||.|....:...:.|| :.||:|:.|....:.|:|::|.||...:::||||
Human    23 LAEVAPVDYLSQYGYLQKPLEGSNNFKPED-ITEALRAFQEASELPVSGQLDDATRARMRQPRCG 86

  Fly   110 VGDRRSADSFSPDNLYHEIGSNVRVRRFALQGPKWSRTDLTWSMVN--RSMPDASKVERMVQTAL 172
            :     .|.|           |.:..::.|.| :|.:..||:.::|  .::|..: ....::.|.
Human    87 L-----EDPF-----------NQKTLKYLLLG-RWRKKHLTFRILNLPSTLPPHT-ARAALRQAF 133

  Fly   173 DVWANHSKLTFREVYSDQADIQILF-ARRAHGDGYKFDGPGQVLAHAFYPGEGRGGDAHFDADET 236
            ..|:|.:.|||:||.:..|||::.| .|::......|||||:|||||..|   ..|..|||.||.
Human   134 QDWSNVAPLTFQEVQAGAADIRLSFHGRQSSYCSNTFDGPGRVLAHADIP---ELGSVHFDEDEF 195

  Fly   237 WNFDGESDDSHGTNFLNVALHELGHSLGLAHSAIPDAVMFPWYQNNEVAGNLPDDDRYGIQQLYG 301
            |.    .....|.|...:|.||:||:|||.||....|:|.|.|:.......|..||..|||.|||
Human   196 WT----EGTYRGVNLRIIAAHEVGHALGLGHSRYSQALMAPVYEGYRPHFKLHPDDVAGIQALYG 256

  Fly   302 TKEKTWGPYKPQTTTTTTTTTTMRAMIYRADKPAYWPWNNPSNNPNNDRNRARERQEEERRRQEK 366
            .|...                                              .|:.:|||
Human   257 KKSPV----------------------------------------------IRDEEEEE------ 269

  Fly   367 ERRRQEEERRHQEEERRRQVEERQRQEEERWRQEQERQEEENRRRKIEHKSQWERNPSKERNRPR 431

Human   270 ----------------------------------------------------------------- 269

  Fly   432 ERQEMERRRQEQERQEQERQEQEDRRRERERDRQLEWERRNRNGAREPVTPTANTTPRPTNKPYP 496
                                                                   |..||..|.|
Human   270 -------------------------------------------------------TELPTVPPVP 279

  Fly   497 TVHRQHHHHNKPRKPKPDSCMTYYDAISI-IRGELFIFRGPYLWRIGTSGLYNGYPTEIRRHWSA 560
            |         :| .|.||.|.:..||:.: .||:.:.|:|.|:|.:..||  .|....:...|..
Human   280 T---------EP-SPMPDPCSSELDAMMLGPRGKTYAFKGDYVWTVSDSG--PGPLFRVSALWEG 332

  Fly   561 LPENLTKVDAVYENKQRQIVFFIGREYYVFNSVMLAPGFPKPLASLGLPPTLTHIDASFVWGHNN 625
            ||.||..  |||..:.:.|.||.|.:.:.:.:..::|||||.|..  :.|.|   ||:..|..|.
Human   333 LPGNLDA--AVYSPRTQWIHFFKGDKVWRYINFKMSPGFPKKLNR--VEPNL---DAALYWPLNQ 390

  Fly   626 RTYMTSGTLYWRIDDYTGQVELDYPRDM-SIWSGVGYNIDAAFQYLDGKTYFFKNLGYWEFNDDR 689
            :.::..|:.||:.|:........||:.: .:::||.....||..:.||:.||||...||..| .:
Human   391 KVFLFKGSGYWQWDELARTDFSSYPKPIKGLFTGVPNQPSAAMSWQDGRVYFFKGKVYWRLN-QQ 454

  Fly   690 MKVAHARAKLSARRWMQC 707
            ::|.....:..:..||.|
Human   455 LRVEKGYPRNISHNWMHC 472

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mmp2	NP_995788.1	Peptidase_M10	143..301	CDD:278824	59/160 (37%)
		ZnMc_MMP	143..301	CDD:239805	59/160 (37%)
		HX	513..707	CDD:238046	60/195 (31%)
MMP19	NP_002420.1	PG_binding_1	31..80	CDD:307564	17/49 (35%)
		Cysteine switch. /evidence=ECO:0000250	83..90		4/11 (36%)
		ZnMc_MMP	103..256	CDD:239805	59/160 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	262..288		13/161 (8%)
		HX	286..472	CDD:238046	60/195 (31%)
		Hemopexin 1	286..333		15/48 (31%)
		Hemopexin 2	334..380		17/49 (35%)
		Hemopexin 3	381..425		10/43 (23%)
		Hemopexin 4	426..472		14/46 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1565
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1075463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10201
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X44
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.920