DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mmp2 and MMP17

DIOPT Version :9

Sequence 1:	NP_995788.1	Gene:	Mmp2 / 35997	FlyBaseID:	FBgn0033438	Length:	758	Species:	Drosophila melanogaster
Sequence 2:	NP_057239.4	Gene:	MMP17 / 4326	HGNCID:	7163	Length:	603	Species:	Homo sapiens

Alignment Length:	714	Identity:	210/714 - (29%)
Similarity:	293/714 - (41%)	Gaps:	222/714 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LATLLALFAQSMCIQELSLPPEGSHSTAATRSKKAKTAISEDIM--YNYLMQFDYLPKSDLETGA 69
            |..||||..:..|......|.                  :||:.  ..:|.:|.|||.:|..||.
Human    25 LLLLLALGTRGGCAAPAPAPR------------------AEDLSLGVEWLSRFGYLPPADPTTGQ 71

  Fly    70 LRTEDQLKEAIRSLQSFGNITVTGEIDSATARLIQKPRCGVGDRRSADSFSPDNLYHEIGSNVRV 134
            |:|:::|.:||.::|.||.:..||.:|.||..|::.|||.:.|.             .:.:..|.
Human    72 LQTQEELSKAITAMQQFGGLEATGILDEATLALMKTPRCSLPDL-------------PVLTQARR 123

  Fly   135 RRFALQGPKWSRTDLTWSMVNRSMPDAS-----KVERMVQTALDVWANHSKLTFREVYSDQADIQ 194
            ||.|....||::.:|:|.:  |:.|..|     .|..::..||.||::.:.|.|.||....||||
Human   124 RRQAPAPTKWNKRNLSWRV--RTFPRDSPLGHDTVRALMYYALKVWSDIAPLNFHEVAGSAADIQ 186

  Fly   195 ILFARRAHGDGYKFDGPGQVLAHAFYPGEGR-GGDAHFDADETWNFDGESDDSHGTNFLNVALHE 258
            |.|::..|.|||.|||||..:||||:||... .||.|||.||.|.|  .|.|:||.:...||:||
Human   187 IDFSKADHNDGYPFDGPGGTVAHAFFPGHHHTAGDTHFDDDEAWTF--RSSDAHGMDLFAVAVHE 249

  Fly   259 LGHSLGLAHSAIPDAVMFPWYQNNEVAGNLPDDDRYGIQQLYGTKEKTWGPYKPQTTTTTTTTTT 323
            .||::||:|.|...::|.|:||     |.:.|..|||:            ||:
Human   250 FGHAIGLSHVAAAHSIMRPYYQ-----GPVGDPLRYGL------------PYE------------ 285

  Fly   324 MRAMIYRADKPAYWPWNNPSNNPNNDRNRARERQEEERRRQEKERRRQEEERRHQEEERRRQVEE 388
                    ||...|
Human   286 --------DKVRVW--------------------------------------------------- 291

  Fly   389 RQRQEEERWRQEQERQEEENRRRKIEHKSQWERNPSKERNRPRERQEMERRRQEQERQEQERQEQ 453

Human   292 ----------------------------------------------------------------- 291

  Fly   454 EDRRRERERDRQLEWERRNRNGAREPVTPTANTTPRPTNKPYPTVHRQHHHHNKPRKPKPDSCMT 518
                       ||       .|.||.|:|||. ...|...|.|..:|.   ...|||..|..|.|
Human   292 -----------QL-------YGVRESVSPTAQ-PEEPPLLPEPPDNRS---SAPPRKDVPHRCST 334

  Fly   519 YYDAISIIRGELFIFRGPYLWRIGTS-GLYNGYPTEIRRHWSALPENLTKVDAVYE-NKQRQIVF 581
            ::||::.||||.|.|:|.|.||:... .|.:..|.::.|.|..||.:|..|||||| ....:|||
Human   335 HFDAVAQIRGEAFFFKGKYFWRLTRDRHLVSLQPAQMHRFWRGLPLHLDSVDAVYERTSDHKIVF 399

  Fly   582 FIGREYYVFNSVMLAPGFPKPLASLGLPPTLTHIDASFVWGHNNRTYMTSGTLYWRIDDYTGQVE 646
            |.|..|:||....:..|:|:|::...|||  ..|||:|.|.||:|||.....||||.||:|..::
Human   400 FKGDRYWVFKDNNVEEGYPRPVSDFSLPP--GGIDAAFSWAHNDRTYFFKDQLYWRYDDHTRHMD 462

  Fly   647 LDYPRDMSIWSGVGYNIDAAFQYLDGKTYFFKNLGYWEFNDDRMKVAHARAKLSARRWMQCARS 710
            ..||....:|.||...:|.|.::.||.:|||:...||:..|..::||....:.:||.|:.|..|
Human   463 PGYPAQSPLWRGVPSTLDDAMRWSDGASYFFRGQEYWKVLDGELEVAPGYPQSTARDWLVCGDS 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mmp2	NP_995788.1	Peptidase_M10	143..301	CDD:278824	69/163 (42%)
		ZnMc_MMP	143..301	CDD:239805	69/163 (42%)
		HX	513..707	CDD:238046	79/195 (41%)
MMP17	NP_057239.4	PG_binding_1	47..105	CDD:279773	23/57 (40%)
		Cysteine switch. /evidence=ECO:0000250	108..115		3/6 (50%)
		Peptidase_M10	132..295	CDD:278824	76/337 (23%)
		ZnMc_MMP	132..295	CDD:239805	76/337 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	301..329		10/31 (32%)
		HX	329..523	CDD:238046	79/195 (41%)
		Hemopexin 1	333..378		17/44 (39%)
		Hemopexin 2	382..427		18/44 (41%)
		Hemopexin 3	428..475		21/48 (44%)
		Hemopexin 4	476..523		15/46 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	537..571
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	49	1.000	Domainoid score	I11824
eggNOG	1	0.900	-	-		E1_KOG1565
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H22669
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1075463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X44
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.820