DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mmp2 and MMP15

DIOPT Version :10

Sequence 1:NP_995788.1 Gene:Mmp2 / 35997 FlyBaseID:FBgn0033438 Length:758 Species:Drosophila melanogaster
Sequence 2:NP_002419.1 Gene:MMP15 / 4324 HGNCID:7161 Length:669 Species:Homo sapiens


Alignment Length:689 Identity:200/689 - (29%)
Similarity:282/689 - (40%) Gaps:194/689 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    52 NYLMQFDYLPKSDLETGALRTEDQLKEAIRSLQSFGNITVTGEIDSATARLIQKPRCGVGDRRSA 116
            |:|..:.|||:.......:|:...|..|:..:|.|..|.|||.:|..|...:::|||||      
Human    55 NWLRLYGYLPQPSRHMSTMRSAQILASALAEMQRFYGIPVTGVLDEETKEWMKRPRCGV------ 113

  Fly   117 DSFSPDNLYHEIGSNVRVR--RFALQGPKWSRTDLTWSMVN--------RSMPDASKVERMVQTA 171
                ||.....:.:|:|.|  |:||.|.||:...||:|:.|        .||       ..|:.|
Human   114 ----PDQFGVRVKANLRRRRKRYALTGRKWNNHHLTFSIQNYTEKLGWYHSM-------EAVRRA 167

  Fly   172 LDVWANHSKLTFREV-YSD-------QADIQILFARRAHGDGYKFDGPGQVLAHAFYPGEGRGGD 228
            ..||...:.|.|:|| |.|       :|||.:|||...|||...|||.|..||||::||.|.|||
Human   168 FRVWEQATPLVFQEVPYEDIRLRRQKEADIMVLFASGFHGDSSPFDGTGGFLAHAYFPGPGLGGD 232

  Fly   229 AHFDADETWNFDGESDDSHGTNFLNVALHELGHSLGLAHSAIPDAVMFPWYQNNEVAG-NLPDDD 292
            .||||||.|.|  .|.|.||.|...||:|||||:|||.||:.|:|:|.|:||..:|.. .||:||
Human   233 THFDADEPWTF--SSTDLHGNNLFLVAVHELGHALGLEHSSNPNAIMAPFYQWKDVDNFKLPEDD 295

  Fly   293 RYGIQQLYGTKEKTWGPYKPQTTTTTTTTTTMRAMIYRADKPAYWPWNNPSNNPNNDRNRARERQ 357
            ..||||||||.:.     :||.|....|.|                                   
Human   296 LRGIQQLYGTPDG-----QPQPTQPLPTVT----------------------------------- 320

  Fly   358 EEERRRQEKERRRQEEERRHQEEERRRQVEERQRQEEERWRQEQERQEEENRRRKIEHKSQWERN 422
                                                                          .|.
Human   321 --------------------------------------------------------------PRR 323

  Fly   423 PSKERNRPRERQEMERRRQEQERQEQERQEQEDRRRERERDRQLEWERRNRNGAREPVTPTANTT 487
            |.:..:||                                             .|.|..|.....
Human   324 PGRPDHRP---------------------------------------------PRPPQPPPPGGK 343

  Fly   488 PRPTNKPYPTVHRQHHHHNKPRKPKPDSCMTYYDAISIIRGELFIFRGPYLWRIGTSGLYNGYPT 552
            |....||.|.|  |.....:|.:..|:.|...:|.::::|||:|:|:|.:.||:..:.:.:.||.
Human   344 PERPPKPGPPV--QPRATERPDQYGPNICDGDFDTVAMLRGEMFVFKGRWFWRVRHNRVLDNYPM 406

  Fly   553 EIRRHWSALPENLTKVDAVYENKQRQIVFFIGREYYVFNSVMLAPGFPKPLASLGLPPTLTHIDA 617
            .|...|..||.:   :.|.||.:..:.|||.|..|::|....|.||:|:||.|.||......||.
Human   407 PIGHFWRGLPGD---ISAAYERQDGRFVFFKGDRYWLFREANLEPGYPQPLTSYGLGIPYDRIDT 468

  Fly   618 SFVWGHNNRTYMTSGTLYWRIDDYTGQVELDYPRDMSIWSGVGYNIDAAFQYLDGK-TYFFKNLG 681
            :..|.....|:......|||.::.|.:.:..||:.:|:|.|:..:...||...|.. |||:|...
Human   469 AIWWEPTGHTFFFQEDRYWRFNEETQRGDPGYPKPISVWQGIPASPKGAFLSNDAAYTYFYKGTK 533

  Fly   682 YWEFNDDRMKVAHARAKLSARRWMQCARSANEVDDEQRW 720
            ||:|:::|:::.....|...|.:|.|   ...|:...||
Human   534 YWKFDNERLRMEPGYPKSILRDFMGC---QEHVEPGPRW 569

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Mmp2NP_995788.1 PG_binding_1 52..103 CDD:460223 16/50 (32%)
Peptidase_M10 143..301 CDD:425668 82/174 (47%)
HX 513..707 CDD:238046 62/194 (32%)
MMP15NP_002419.1 PG_binding_1 53..106 CDD:460223 16/50 (32%)
Cysteine switch. /evidence=ECO:0000250 109..116 6/16 (38%)
Peptidase_M10 138..304 CDD:425668 82/174 (47%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 300..370 26/218 (12%)
HX 367..559 CDD:238046 62/194 (32%)
Hemopexin 1 367..415 15/47 (32%)
Hemopexin 2 416..461 19/47 (40%)
Hemopexin 3 463..511 13/47 (28%)
Hemopexin 4 512..559 14/46 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 574..593
DUF3377 <643..669 CDD:463374
Blue background indicates that the domain is not in the aligned region.

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