Protein Alignment Mmp2 and MMP14

DIOPT Version :10

• Sequence 1: NP_995788.1
• Gene: Mmp2 / 35997
• FlyBaseID: FBgn0033438
• Length: 758
• Species: Drosophila melanogaster
• Sequence 2: NP_004986.1
• Gene: MMP14 / 4323
• HGNCID: 7160
• Length: 582
• Species: Homo sapiens
• Alignment Length: 766
• Identity: 205/766 - (26%)
• Similarity: 303/766 - (39%)
• Gaps: 244/766 - (31%)

  Fly     7 LATLLALFAQSMCIQELSLPPEGSHSTAATRSKKAKTAISEDIMYNYLMQFDYLPKSDLETGALR 71
            |.||....|.....|..|..||.                       :|.|:.|||..||.|...|
Human    15 LLTLGTALASLGSAQSSSFSPEA-----------------------WLQQYGYLPPGDLRTHTQR 56

  Fly    72 TEDQLKEAIRSLQSFGNITVTGEIDSATARLIQKPRCGVGDRRSADSFSPDNLYHEIGSNVRVRR 136
            :...|..||.::|.|..:.|||:.|:.|.:.:::|||||          ||....||.:|||.:|
Human    57 SPQSLSAAIAAMQKFYGLQVTGKADADTMKAMRRPRCGV----------PDKFGAEIKANVRRKR 111

  Fly   137 FALQGPKWSRTDLTWSMVNRSMPDASK--VERMVQTALDVWANHSKLTFREV--------YSDQA 191
            :|:||.||...::|:.:.|.: |...:  ....::.|..||.:.:.|.||||        :..||
Human   112 YAIQGLKWQHNEITFCIQNYT-PKVGEYATYEAIRKAFRVWESATPLRFREVPYAYIREGHEKQA 175

  Fly   192 DIQILFARRAHGDGYKFDGPGQVLAHAFYPGEGRGGDAHFDADETWNFDGESDDSHGTNFLNVAL 256
            ||.|.||...|||...|||.|..||||::||...|||.|||:.|.|..  .::|.:|.:...||:
Human   176 DIMIFFAEGFHGDSTPFDGEGGFLAHAYFPGPNIGGDTHFDSAEPWTV--RNEDLNGNDIFLVAV 238

  Fly   257 HELGHSLGLAHSAIPDAVMFPWYQ----NNEVAGNLPDDDRYGIQQLYGTKEKTWGPYKPQTTTT 317
            |||||:|||.||:.|.|:|.|:||    .|.|   ||||||.|||||||
Human   239 HELGHALGLEHSSDPSAIMAPFYQWMDTENFV---LPDDDRRGIQQLYG---------------- 284

  Fly   318 TTTTTTMRAMIYRADKPAYWPWNNPSNNPNNDRNRARERQEEERRRQEKERRRQEEERRHQEEER 382
                                                                             
Human   285 ----------------------------------------------------------------- 284

  Fly   383 RRQVEERQRQEEERWRQEQERQEEENRRRKIEHKSQWERNPSKERNRPRERQEMERRRQEQERQE 447
                                                                             
Human   285 ----------------------------------------------------------------- 284

  Fly   448 QERQEQEDRRRERERDRQLEWERRNRNGAREPVTPTANTTPRPTNKPYPTVHRQHHHHNKPRKPK 512
                                    ..:|....:.|...||.||:   .|         :||:.|.
Human   285 ------------------------GESGFPTKMPPQPRTTSRPS---VP---------DKPKNPT 313

  Fly   513 --PDSCMTYYDAISIIRGELFIFRGPYLWRIGTSGLYNGYPTEIRRHWSALPENLTKVDAVYENK 575
              |:.|...:|.::::|||:|:|:..:.||:..:.:.:|||..|.:.|..||   ..::..||.|
Human   314 YGPNICDGNFDTVAMLRGEMFVFKERWFWRVRNNQVMDGYPMPIGQFWRGLP---ASINTAYERK 375

  Fly   576 QRQIVFFIGREYYVFNSVMLAPGFPKPLASLGLPPTLTHIDASFVWGHNNRTYMTSGTLYWRIDD 640
            ..:.|||.|.:::||:...|.||:||.:..||.......|||:..|..|.:||...|..|:|.::
Human   376 DGKFVFFKGDKHWVFDEASLEPGYPKHIKELGRGLPTDKIDAALFWMPNGKTYFFRGNKYYRFNE 440

  Fly   641 YTGQVELDYPRDMSIWSGVGYNIDAAFQYLDGK-TYFFKNLGYWEFNDDRMKVAHARAKLSARRW 704
            ....|:.:||:::.:|.|:..:...:|...|.. |||:|...||:||:.::||.....|.:.|.|
Human   441 ELRAVDSEYPKNIKVWEGIPESPRGSFMGSDEVFTYFYKGNKYWKFNNQKLKVEPGYPKSALRDW 505

  Fly   705 MQCARSANEVDD--EQRWTASLVSEGEETGRSGSRELRINHFILSILLLAI 753
            |.|. |....|:  |:.....::...||.|.:.|....:...:|.:|:||:
Human   506 MGCP-SGGRPDEGTEEETEVIIIEVDEEGGGAVSAAAVVLPVLLLLLVLAV 555

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mmp2	NP_995788.1	PG_binding_1	52..103	CDD:460223	19/50 (38%)
		Peptidase_M10	143..301	CDD:425668	74/171 (43%)
		HX	513..707	CDD:238046	64/194 (33%)
MMP14	NP_004986.1	PG_binding_1	36..88	CDD:460223	20/74 (27%)
		Peptidase_M10	118..284	CDD:425668	74/171 (43%)
		HX	316..508	CDD:238046	64/194 (33%)
		DUF3377	<560..582	CDD:463374