DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mmp2 and MMP13

DIOPT Version :9

Sequence 1:	NP_995788.1	Gene:	Mmp2 / 35997	FlyBaseID:	FBgn0033438	Length:	758	Species:	Drosophila melanogaster
Sequence 2:	NP_002418.1	Gene:	MMP13 / 4322	HGNCID:	7159	Length:	471	Species:	Homo sapiens

Alignment Length:	704	Identity:	180/704 - (25%)
Similarity:	258/704 - (36%)	Gaps:	278/704 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 VLATLLALFAQSMCIQELSLPPEGSHSTAATRSKKAKTAISEDIMY--NYLMQFDYLPKSDLETG 68
            |||..|.| :.:.| :.|.||..|.....:          .||:.:  .||..: |.|.:  ..|
Human     5 VLAAFLFL-SWTHC-RALPLPSGGDEDDLS----------EEDLQFAERYLRSY-YHPTN--LAG 54

  Fly    69 ALR--TEDQLKEAIRSLQSFGNITVTGEIDSATARLIQKPRCGVGDRRSADSFSPDNLYHEIGS- 130
            .|:  ....:.|.:|.:|||..:.|||::|..|..:::||||||.|               :|.
Human    55 ILKENAASSMTERLREMQSFFGLEVTGKLDDNTLDVMKKPRCGVPD---------------VGEY 104

  Fly   131 NVRVRRFALQGPKWSRTDLTWSMVNRSMPDA--SKVERMVQTALDVWANHSKLTFREVYSDQADI 193
            ||..|..     |||:.:||:.:||.: ||.  |:||:..:.|..||::.:.|.|..::...|||
Human   105 NVFPRTL-----KWSKMNLTYRIVNYT-PDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADI 163

  Fly   194 QILFARRAHGDGYKFDGPGQVLAHAFYPGEGRGGDAHFDADETWNFDGESDDSHGTNFLNVALHE 258
            .|.|..:.|||.|.||||..:|||||.||...|||||||.||||     :..|.|.|...||.||
Human   164 MISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETW-----TSSSKGYNLFLVAAHE 223

  Fly   259 LGHSLGLAHSAIPDAVMFPWYQNNEVAGN----LPDDDRYGIQQLYGTKEKTWGPYKPQTTTTTT 319
            .||||||.||..|.|:|||.|   ...|.    |||||..|||.|||..::
Human   224 FGHSLGLDHSKDPGALMFPIY---TYTGKSHFMLPDDDVQGIQSLYGPGDE-------------- 271

  Fly   320 TTTTMRAMIYRADKPAYWPWNNPSNNPNNDRNRARERQEEERRRQEKERRRQEEERRHQEEERRR 384
                                     :||
Human   272 -------------------------DPN------------------------------------- 274

  Fly   385 QVEERQRQEEERWRQEQERQEEENRRRKIEHKSQWERNPSKERNRPRERQEMERRRQEQERQEQE 449

Human   275 ----------------------------------------------------------------- 274

  Fly   450 RQEQEDRRRERERDRQLEWERRNRNGAREPVTPTANTTPRPTNKPYPTVHRQHHHHNKPRKPK-P 513
                                                                      |:.|| |
Human   275 ----------------------------------------------------------PKHPKTP 281

  Fly   514 DSC--MTYYDAISIIRGELFIFRGPYLWRIGTSGLYNGYPTEI-------RRHWSALPENLTKVD 569
            |.|  ....|||:.:|||..||:..:.||:        :|.::       :..|..||   .::|
Human   282 DKCDPSLSLDAITSLRGETMIFKDRFFWRL--------HPQQVDAELFLTKSFWPELP---NRID 335

  Fly   570 AVYENKQRQIVF-FIGREYYVFNSVMLAPGFPKPLASLGLPPTLTHIDASFVWGHNNRTYMTSGT 633
            |.||:....::| |.||:::..|...:..|:||.::.||||..:..|.|:..:....:|.:.||.
Human   336 AAYEHPSHDLIFIFRGRKFWALNGYDILEGYPKKISELGLPKEVKKISAAVHFEDTGKTLLFSGN 400

  Fly   634 LYWRIDDYTGQVELDYPRDM-SIWSGVGYNIDAAFQYLDGKTYFFKNLGYWEFN 686
            ..||.||....::.||||.: ..:.|:|..:||.:: .:|..|||.....:|::
Human   401 QVWRYDDTNHIMDKDYPRLIEEDFPGIGDKVDAVYE-KNGYIYFFNGPIQFEYS 453

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mmp2	NP_995788.1	Peptidase_M10	143..301	CDD:278824	79/163 (48%)
		ZnMc_MMP	143..301	CDD:239805	79/163 (48%)
		HX	513..707	CDD:238046	55/185 (30%)
MMP13	NP_002418.1	PG_binding_1	32..91	CDD:307564	18/71 (25%)
		Cysteine switch. /evidence=ECO:0000250	94..101		6/21 (29%)
		Peptidase_M10	112..267	CDD:306839	79/163 (48%)
		Interaction with TIMP2	176..246		44/77 (57%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	263..284		11/219 (5%)
		Interaction with collagen	268..471		60/397 (15%)
		HX	281..471	CDD:238046	55/185 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1565
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1075463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10201
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X44
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.920