DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mmp2 and MMP11

DIOPT Version :9

Sequence 1:	NP_995788.1	Gene:	Mmp2 / 35997	FlyBaseID:	FBgn0033438	Length:	758	Species:	Drosophila melanogaster
Sequence 2:	NP_005931.2	Gene:	MMP11 / 4320	HGNCID:	7157	Length:	488	Species:	Homo sapiens

Alignment Length:	718	Identity:	198/718 - (27%)
Similarity:	258/718 - (35%)	Gaps:	252/718 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 SKYVLATLLALFAQSMCIQELSLPPEGSHSTAATRSKKAKTAISEDIMYNYLMQFDYLPKSDLET 67
            ::.:|..:|.|..|...:...:|||:..|..|..|..:...|.              ||.|....
Human    12 ARALLPPMLLLLLQPPPLLARALPPDAHHLHAERRGPQPWHAA--------------LPSSPAPA 62

  Fly    68 GALRTEDQLKEAIRSLQSFGNITVTGEIDSATARLIQKPRCGVGDRRSADSFSPDNLYHEIGSNV 132
            .|      .:||.|...|                 ::.|||||.|  .:|..|..|
Human    63 PA------TQEAPRPASS-----------------LRPPRCGVPD--PSDGLSARN--------- 93

  Fly   133 RVRRFALQGPKWSRTDLT-------WSMVNRSMPDASKVERMVQTALDVWANHSKLTFREVYSDQ 190
            |.:||.|.|.:|.:||||       |.:|.      .:|.:.:..||.||::.:.|||.||:..:
Human    94 RQKRFVLSGGRWEKTDLTYRILRFPWQLVQ------EQVRQTMAEALKVWSDVTPLTFTEVHEGR 152

  Fly   191 ADIQILFARRAHGDGYKFDGPGQVLAHAFYPGEGRGGDAHFDADETWNFDGESDDSHGTNFLNVA 255
            |||.|.|||..|||...|||||.:|||||:|...|.||.|||.||||..    .|..||:.|.||
Human   153 ADIMIDFARYWHGDDLPFDGPGGILAHAFFPKTHREGDVHFDYDETWTI----GDDQGTDLLQVA 213

  Fly   256 LHELGHSLGLAHSAIPDAVMFPWYQNNEVAGNLPDDDRYGIQQLYGTKEKTWGPYKPQTTTTTTT 320
            .||.||.|||.|:....|:|..:|.........|||.| |:|.|||         :|..|.|:.|
Human   214 AHEFGHVLGLQHTTAAKALMSAFYTFRYPLSLSPDDCR-GVQHLYG---------QPWPTVTSRT 268

  Fly   321 TTTMRAMIYRADKPAYWPWNNPSNNPNNDRNRARERQEEERRRQEKERRRQEEERRHQEEERRRQ 385
                         ||..|      ....|.|..
Human   269 -------------PALGP------QAGIDTNEI-------------------------------- 282

  Fly   386 VEERQRQEEERWRQEQERQEEENRRRKIEHKSQWERNPSKERNRPRERQEMERRRQEQERQEQER 450

Human   283 ----------------------------------------------------------------- 282

  Fly   451 QEQEDRRRERERDRQLEWERRNRNGAREPVTPTANTTPRPTNKPYPTVHRQHHHHNKPRKPKPDS 515
                                       .|:.|.|                           .||:
Human   283 ---------------------------APLEPDA---------------------------PPDA 293

  Fly   516 CMTYYDAISIIRGELFIFRGPYLWRIGTSGLYNGYPTEIRRHWSALPENLTKVDAVYENKQRQIV 580
            |...:||:|.||||||.|:..::||:....|..|||....|||..||   :.|||.:|:.|..|.
Human   294 CEASFDAVSTIRGELFFFKAGFVWRLRGGQLQPGYPALASRHWQGLP---SPVDAAFEDAQGHIW 355

  Fly   581 FFIGREYYVFNSVMLAPGFPKPLASLGLPPTLTHIDASFVWG-HNNRTYMTSGTLYWRIDDYTGQ 644
            ||.|.:|:|::......| |.||..|||.....|  |:.||| ..|:.|...|..|||....|.:
Human   356 FFQGAQYWVYDGEKPVLG-PAPLTELGLVRFPVH--AALVWGPEKNKIYFFRGRDYWRFHPSTRR 417

  Fly   645 VELDYPRDMSIWSGVGYNIDAAFQYLDGKTYFFKNLGYWEFNDDRMKVAHARAKLSARRWMQCAR 709
            |:...||..:.|.||...||||||..||..||.:...||:|:..::|......:|....:..||.
Human   418 VDSPVPRRATDWRGVPSEIDAAFQDADGYAYFLRGRLYWKFDPVKVKALEGFPRLVGPDFFGCAE 482

  Fly   710 SAN 712
            .||
Human   483 PAN 485

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mmp2	NP_995788.1	Peptidase_M10	143..301	CDD:278824	72/164 (44%)
		ZnMc_MMP	143..301	CDD:239805	72/164 (44%)
		HX	513..707	CDD:238046	75/194 (39%)
MMP11	NP_005931.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	41..93		19/90 (21%)
		Cysteine switch. /evidence=ECO:0000250	78..85		6/8 (75%)
		Peptidase_M10	104..258	CDD:278824	72/164 (44%)
		ZnMc_MMP	104..258	CDD:239805	72/164 (44%)
		HX	291..480	CDD:238046	75/194 (39%)
		Hemopexin 1	291..339		22/47 (47%)
		Hemopexin 2	340..382		17/45 (38%)
		Hemopexin 3	384..432		16/49 (33%)
		Hemopexin 4	433..480		15/46 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1565
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1075463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10201
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X44
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	6	5.880