DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mmp2 and MMP10

DIOPT Version :9

Sequence 1:	NP_995788.1	Gene:	Mmp2 / 35997	FlyBaseID:	FBgn0033438	Length:	758	Species:	Drosophila melanogaster
Sequence 2:	NP_002416.1	Gene:	MMP10 / 4319	HGNCID:	7156	Length:	476	Species:	Homo sapiens

Alignment Length:	679	Identity:	178/679 - (26%)
Similarity:	256/679 - (37%)	Gaps:	249/679 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 SEDIMYNYLMQFDYLPKSDLETGALRTEDQLKEAIRSLQSFGNITVTGEIDSATARLIQKPRCGV 110
            ::|:...||.::..|.| |::....:..:.:.:.|:.:|.|..:.|||::|:.|..:::||||||
Human    30 NKDLAQQYLEKYYNLEK-DVKQFRRKDSNLIVKKIQGMQKFLGLEVTGKLDTDTLEVMRKPRCGV 93

  Fly   111 GDRRSADSFSPDNLYHEIGSNVRVRRFALQG-PKWSRTDLTWSMVNRSMPDASK--VERMVQTAL 172
            .|.....||                    .| |||.:|.||:.:||.: ||..:  |:..::.||
Human    94 PDVGHFSSF--------------------PGMPKWRKTHLTYRIVNYT-PDLPRDAVDSAIEKAL 137

  Fly   173 DVWANHSKLTFREVYSDQADIQILFARRAHGDGYKFDGPGQVLAHAFYPGEGRGGDAHFDADETW 237
            .||...:.|||..:|..:|||.|.||.:.|||.|.|||||..||||:.||.|..||.|||.||.|
Human   138 KVWEEVTPLTFSRLYEGEADIMISFAVKEHGDFYSFDGPGHSLAHAYPPGPGLYGDIHFDDDEKW 202

  Fly   238 NFDGESDDSHGTNFLNVALHELGHSLGLAHSAIPDAVMFPWYQN-NEVAG-NLPDDDRYGIQQLY 300
                 ::|:.|||...||.|||||||||.|||..:|:|:|.|.: .|:|. .|..||..|||.||
Human   203 -----TEDASGTNLFLVAAHELGHSLGLFHSANTEALMYPLYNSFTELAQFRLSQDDVNGIQSLY 262

  Fly   301 GTKEKTWGPYKPQTTTTTTTTTTMRAMIYRADKPAYWPWNNPSNNPNNDRNRARERQEEERRRQE 365
            |          |...:|
Human   263 G----------PPPAST------------------------------------------------ 269

  Fly   366 KERRRQEEERRHQEEERRRQVEERQRQEEERWRQEQERQEEENRRRKIEHKSQWERNPSKERNRP 430

Human   270 ----------------------------------------------------------------- 269

  Fly   431 RERQEMERRRQEQERQEQERQEQEDRRRERERDRQLEWERRNRNGAREPVTPTANTTPRPTNKPY 495
                                                          .||:.||.:.   |:....
Human   270 ----------------------------------------------EEPLVPTKSV---PSGSEM 285

  Fly   496 PTVHRQHHHHNKPRKPKPDSCMTYYDAISIIRGELFIFRGPYLWRIGTSGLYNGYPTEIRRHWSA 560
            |.              |.|..:: :||||.:|||...|:..|.||              |.||:.
Human   286 PA--------------KCDPALS-FDAISTLRGEYLFFKDRYFWR--------------RSHWNP 321

  Fly   561 LPE---------NL-TKVDAVYENKQRQIVF-FIGREYYVFNSVMLAPGFPKPLASLGLPPTLTH 614
            .||         :| :.:||.||...|..|| |.|.|::......:..|:|:.:.:||.|||:..
Human   322 EPEFHLISAFWPSLPSYLDAAYEVNSRDTVFIFKGNEFWAIRGNEVQAGYPRGIHTLGFPPTIRK 386

  Fly   615 IDASFVWGHNNRTYMTSGTLYWRIDDYTGQVELDYPRDMS-IWSGVGYNIDAAFQYLDGKTYFFK 678
            |||:.......:||..:...|||.|:.:..:|..:||.:: .:.||...:||..|.. |..|||.
Human   387 IDAAVSDKEKKKTYFFAADKYWRFDENSQSMEQGFPRLIADDFPGVEPKVDAVLQAF-GFFYFFS 450

  Fly   679 NLGYWEFNDDRMKVAHARAKLSARRWMQC 707
            ....:||:.:...|.|.   |.:..|:.|
Human   451 GSSQFEFDPNARMVTHI---LKSNSWLHC 476

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mmp2	NP_995788.1	Peptidase_M10	143..301	CDD:278824	79/161 (49%)
		ZnMc_MMP	143..301	CDD:239805	79/161 (49%)
		HX	513..707	CDD:238046	62/205 (30%)
MMP10	NP_002416.1	PG_binding_1	33..86	CDD:307564	13/53 (25%)
		Cysteine switch. /evidence=ECO:0000250	89..96		5/6 (83%)
		Peptidase_M10	107..263	CDD:306839	79/161 (49%)
		HX	286..476	CDD:238046	64/222 (29%)
		Hemopexin 1	286..335		19/77 (25%)
		Hemopexin 2	336..382		14/45 (31%)
		Hemopexin 3	384..432		12/47 (26%)
		Hemopexin 4	433..476		13/46 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1565
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1075463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10201
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X44
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.920