DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mmp2 and MMP7

DIOPT Version :9

Sequence 1:	NP_995788.1	Gene:	Mmp2 / 35997	FlyBaseID:	FBgn0033438	Length:	758	Species:	Drosophila melanogaster
Sequence 2:	NP_002414.1	Gene:	MMP7 / 4316	HGNCID:	7174	Length:	267	Species:	Homo sapiens

Alignment Length:	303	Identity:	118/303 - (38%)
Similarity:	163/303 - (53%)	Gaps:	47/303 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LLALFAQSMCIQELSLP-PEGSHSTAATRSKKAKTAISEDIMYNYLMQFDYLPKSDLETGALRTE 73
            |..|.|..:....|:|| |:.:...:..:.::|:         :||.:| ||  .|.||   :..
Human     3 LTVLCAVCLLPGSLALPLPQEAGGMSELQWEQAQ---------DYLKRF-YL--YDSET---KNA 52

  Fly    74 DQLKEAIRSLQSFGNITVTGEIDSATARLIQKPRCGVGDRRSADSFSPDNLYHEIGSNVRVRRFA 138
            :.|:..::.:|.|..:.:||.::|....::|||||||.|                     |..::
Human    53 NSLEAKLKEMQKFFGLPITGMLNSRVIEIMQKPRCGVPD---------------------VAEYS 96

  Fly   139 L--QGPKWSRTDLTWSMVN--RSMPDASKVERMVQTALDVWANHSKLTFREVYSDQADIQILFAR 199
            |  ..|||:...:|:.:|:  |.:|..: |:|:|..||::|.....|.||:|....|||.|.|||
Human    97 LFPNSPKWTSKVVTYRIVSYTRDLPHIT-VDRLVSKALNMWGKEIPLHFRKVVWGTADIMIGFAR 160

  Fly   200 RAHGDGYKFDGPGQVLAHAFYPGEGRGGDAHFDADETWNFDGESDDSHGTNFLNVALHELGHSLG 264
            .||||.|.|||||..|||||.||.|.|||||||.||.|. ||   .|.|.|||..|.||||||||
Human   161 GAHGDSYPFDGPGNTLAHAFAPGTGLGGDAHFDEDERWT-DG---SSLGINFLYAATHELGHSLG 221

  Fly   265 LAHSAIPDAVMFPWYQNNEVAG-NLPDDDRYGIQQLYGTKEKT 306
            :.||:.|:|||:|.|.|.:... .|..||..|||:|||.:..:
Human   222 MGHSSDPNAVMYPTYGNGDPQNFKLSQDDIKGIQKLYGKRSNS 264

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mmp2	NP_995788.1	Peptidase_M10	143..301	CDD:278824	83/160 (52%)
		ZnMc_MMP	143..301	CDD:239805	83/160 (52%)
		HX	513..707	CDD:238046
MMP7	NP_002414.1	PG_binding_1	31..82	CDD:396175	15/65 (23%)
		Cysteine switch. /evidence=ECO:0000250	85..92		6/27 (22%)
		Peptidase_M10	103..259	CDD:395334	83/160 (52%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	153	1.000	Domainoid score	I4299
eggNOG	1	0.900	-	-		E1_KOG1565
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1075463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10201
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X44
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.920