Protein Alignment Mmp2 and MMP3

DIOPT Version :10

• Sequence 1: NP_995788.1
• Gene: Mmp2 / 35997
• FlyBaseID: FBgn0033438
• Length: 758
• Species: Drosophila melanogaster
• Sequence 2: NP_002413.1
• Gene: MMP3 / 4314
• HGNCID: 7173
• Length: 477
• Species: Homo sapiens
• Alignment Length: 713
• Identity: 189/713 - (26%)
• Similarity: 265/713 - (37%)
• Gaps: 256/713 - (35%)

  Fly    10 LLALFAQSMCIQELSLPPEGSHSTAATRSKKAKTAISEDIMYNYLMQFDYLPKSDLETGALRTED 74
            :|.|...::|   .:.|.:|     |.|.:.....:.:..:.||     |..|.|::....|.:.
Human     6 ILLLLCVAVC---SAYPLDG-----AARGEDTSMNLVQKYLENY-----YDLKKDVKQFVRRKDS 57

  Fly    75 -QLKEAIRSLQSFGNITVTGEIDSATARLIQKPRCGVGDRRSADSFSPDNLYHEIGSNVRVRRFA 138
             .:.:.||.:|.|..:.|||::||.|..:::||||||.|               :|   ..|.|
Human    58 GPVVKKIREMQKFLGLEVTGKLDSDTLEVMRKPRCGVPD---------------VG---HFRTF- 103

  Fly   139 LQG-PKWSRTDLTWSMVNRSMPDASK--VERMVQTALDVWANHSKLTFREVYSDQADIQILFARR 200
             .| |||.:|.||:.:||.: ||..|  |:..|:.||.||...:.|||..:|..:|||.|.||.|
Human   104 -PGIPKWRKTHLTYRIVNYT-PDLPKDAVDSAVEKALKVWEEVTPLTFSRLYEGEADIMISFAVR 166

  Fly   201 AHGDGYKFDGPGQVLAHAFYPGEGRGGDAHFDADETWNFDGESDDSHGTNFLNVALHELGHSLGL 265
            .|||.|.|||||.|||||:.||.|..||||||.||.|     :.|:.|||...||.||:||||||
Human   167 EHGDFYPFDGPGNVLAHAYAPGPGINGDAHFDDDEQW-----TKDTTGTNLFLVAAHEIGHSLGL 226

  Fly   266 AHSAIPDAVMFPWYQN--NEVAGNLPDDDRYGIQQLYGTKEKTWGPYKPQTTTTTTTTTTMRAMI 328
            .|||..:|:|:|.|.:  :.....|..||..|||.|||..     |..|:|
Human   227 FHSANTEALMYPLYHSLTDLTRFRLSQDDINGIQSLYGPP-----PDSPET-------------- 272

  Fly   329 YRADKPAYWPWNNPSNNPNNDRNRARERQEEERRRQEKERRRQEEERRHQEEERRRQVEERQRQE 393
                                                                             
Human   273 ----------------------------------------------------------------- 272

  Fly   394 EERWRQEQERQEEENRRRKIEHKSQWERNPSKERNRPRERQEMERRRQEQERQEQERQEQEDRRR 458
                                                                             
Human   273 ----------------------------------------------------------------- 272

  Fly   459 ERERDRQLEWERRNRNGAREPVTPTANTTPRPTNKPYPTVHRQHHHHNKPRKPKPDSC--MTYYD 521
                                |:.||....|.|..                    |.:|  ...:|
Human   273 --------------------PLVPTEPVPPEPGT--------------------PANCDPALSFD 297

  Fly   522 AISIIRGELFIFRGPYLWRIGTSGLYNGYPTEIRRH-----WSALPENLTKVDAVYENKQRQIVF 581
            |:|.:|||:.||:..:.||.....|      |...|     |.:||..   |||.||...:.:||
Human   298 AVSTLRGEILIFKDRHFWRKSLRKL------EPELHLISSFWPSLPSG---VDAAYEVTSKDLVF 353

  Fly   582 -FIGREYYVFNSVMLAPGFPKPLASLGLPPTLTHIDASFVWGHNNRTYMTSGTLYWRIDDYTGQV 645
             |.|.:::......:..|:|:.:.:||.|||:..|||:......|:||......|||.|:....:
Human   354 IFKGNQFWAIRGNEVRAGYPRGIHTLGFPPTVRKIDAAISDKEKNKTYFFVEDKYWRFDEKRNSM 418

  Fly   646 ELDYPRDMS-IWSGVGYNIDAAFQYLDGKTYFFKNLGYWEFNDDRMKVAHARAKLSARRWMQC 707
            |..:|:.:: .:.|:...|||.|:.. |..|||......||:.:..||.|.   |.:..|:.|
Human   419 EPGFPKQIAEDFPGIDSKIDAVFEEF-GFFYFFTGSSQLEFDPNAKKVTHT---LKSNSWLNC 477

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mmp2	NP_995788.1	PG_binding_1	52..103	CDD:460223	16/51 (31%)
		Peptidase_M10	143..301	CDD:425668	81/161 (50%)
		HX	513..707	CDD:238046	62/202 (31%)
MMP3	NP_002413.1	PG_binding_1	25..87	CDD:460223	17/66 (26%)
		Cysteine switch. /evidence=ECO:0000250	90..97		6/21 (29%)
		Peptidase_M10	108..264	CDD:425668	81/161 (50%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	262..287		11/213 (5%)
		HX	287..477	CDD:238046	62/202 (31%)
		Hemopexin 1	287..336		16/54 (30%)
		Hemopexin 2	337..383		14/48 (29%)
		Hemopexin 3	385..433		12/47 (26%)
		Hemopexin 4	434..477		15/46 (33%)