DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mmp2 and MMP1

DIOPT Version :9

Sequence 1:	NP_995788.1	Gene:	Mmp2 / 35997	FlyBaseID:	FBgn0033438	Length:	758	Species:	Drosophila melanogaster
Sequence 2:	NP_002412.1	Gene:	MMP1 / 4312	HGNCID:	7155	Length:	469	Species:	Homo sapiens

Alignment Length:	694	Identity:	169/694 - (24%)
Similarity:	254/694 - (36%)	Gaps:	254/694 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 SHSTAATRSKKAKTAISEDIMYNYLMQFDYLPKSDLETGALRTEDQLKEAIRSLQSFGNITVTGE 94
            |||..||...:.:..   |::..||.::..|.....:....|....:.|.::.:|.|..:.|||:
Human    17 SHSFPATLETQEQDV---DLVQKYLEKYYNLKNDGRQVEKRRNSGPVVEKLKQMQEFFGLKVTGK 78

  Fly    95 IDSATARLIQKPRCGVGDRRSADSFSPDNLYHEIGSNVRVRRFALQ--GPKWSRTDLTWSMVNRS 157
            .|:.|.:::::|||||.|                     |.:|.|.  .|:|.:|.||:.:.|.:
Human    79 PDAETLKVMKQPRCGVPD---------------------VAQFVLTEGNPRWEQTHLTYRIENYT 122

  Fly   158 MPDASK--VERMVQTALDVWANHSKLTFREVYSDQADIQILFARRAHGDGYKFDGPGQVLAHAFY 220
             ||..:  |:..::.|..:|:|.:.|||.:|...||||.|.|.|..|.|...|||||..|||||.
Human   123 -PDLPRADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGNLAHAFQ 186

  Fly   221 PGEGRGGDAHFDADETWNFDGESDDSHGTNFLNVALHELGHSLGLAHSAIPDAVMFPWYQ-NNEV 284
            ||.|.|||||||.||.|     :::....|...||.|||||||||:||....|:|:|.|. :.:|
Human   187 PGPGIGGDAHFDEDERW-----TNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSYTFSGDV 246

  Fly   285 AGNLPDDDRYGIQQLYGTKEKTWGPYKPQTTTTTTTTTTMRAMIYRADKPAYWPWNNPSNNPNND 349
              .|..||..|||.:||
Human   247 --QLAQDDIDGIQAIYG------------------------------------------------ 261

  Fly   350 RNRARERQEEERRRQEKERRRQEEERRHQEEERRRQVEERQRQEEERWRQEQERQEEENRRRKIE 414

Human   262 ----------------------------------------------------------------- 261

  Fly   415 HKSQWERNPSKERNRPRERQEMERRRQEQERQEQERQEQEDRRRERERDRQLEWERRNRNGAREP 479
                                                                    |::|    |
Human   262 --------------------------------------------------------RSQN----P 266

  Fly   480 VTPTANTTPRPTNKPYPTVHRQHHHHNKPRKPKPDSCMTYYDAISIIRGELFIFRGPYLWRIGTS 544
            |.|....||:..                      ||.:| :|||:.||||:..|:..:..|.
Human   267 VQPIGPQTPKAC----------------------DSKLT-FDAITTIRGEVMFFKDRFYMRT--- 305

  Fly   545 GLYNGYPTEIRRH-----WSALPENLTKVDAVYENKQR-QIVFFIGREYYVFNSVMLAPGFPKPL 603
               |.:..|:..:     |..||..|   :|.||...| ::.||.|.:|:......:..|:||.:
Human   306 ---NPFYPEVELNFISVFWPQLPNGL---EAAYEFADRDEVRFFKGNKYWAVQGQNVLHGYPKDI 364

  Fly   604 -ASLGLPPTLTHIDASFVWGHNNRTYMTSGTLYWRIDDYTGQVELDYPRDMS-IWSGVGYNIDAA 666
             :|.|.|.|:.||||:....:..:||......|||.|:|...::..||:.:: .:.|:|:.:||.
Human   365 YSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFPGIGHKVDAV 429

  Fly   667 FQYLDGKTYFFKNLGYWEFNDDRMKVAHARAKLSARRWMQCARS 710
            |. .||..|||.....::|:....::...:   .|..|..|.::
Human   430 FM-KDGFFYFFHGTRQYKFDPKTKRILTLQ---KANSWFNCRKN 469

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mmp2	NP_995788.1	Peptidase_M10	143..301	CDD:278824	72/160 (45%)
		ZnMc_MMP	143..301	CDD:239805	72/160 (45%)
		HX	513..707	CDD:238046	59/201 (29%)
MMP1	NP_002412.1	PG_binding_1	27..87	CDD:396175	13/62 (21%)
		Cysteine switch. /evidence=ECO:0000269\|PubMed:15611040, ECO:0000269\|PubMed:2153297	90..97		6/27 (22%)
		Metalloprotease	98..276		83/358 (23%)
		Peptidase_M10	108..261	CDD:395334	72/160 (45%)
		HX	275..466	CDD:238046	60/226 (27%)
		Hemopexin 1	275..324		16/77 (21%)
		Hemopexin 2	325..371		15/48 (31%)
		Hemopexin 3	374..422		13/47 (28%)
		Hemopexin 4	423..466		12/46 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1565
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1075463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10201
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3504
SonicParanoid	1	1.000	-	-		X44
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.950