DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mmp2 and mmp9

DIOPT Version :9

Sequence 1:	NP_995788.1	Gene:	Mmp2 / 35997	FlyBaseID:	FBgn0033438	Length:	758	Species:	Drosophila melanogaster
Sequence 2:	NP_998288.1	Gene:	mmp9 / 406397	ZFINID:	ZDB-GENE-040426-2132	Length:	680	Species:	Danio rerio

Alignment Length:	851	Identity:	177/851 - (20%)
Similarity:	264/851 - (31%)	Gaps:	395/851 - (46%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 KTAISEDIMYNYLMQFDYLPKSDLETGALRTEDQLKEAIRSLQSFGNITVTGEIDSATARLIQKP 106
            |...:..:...||.::.|:  ..|:...|:......:|::.||....:..||.:|..|...:::|
Zfish    36 KNMTNTQLADEYLKRYGYV--DVLQRSGLQAVISNAKALKKLQRQLGLEETGLLDQPTVDAMKQP 98

  Fly   107 RCGVGDRRSADSFSPDNLYHEIGSNVRVRRFALQGPKWSRTDLTWSMVNRSMPD--ASKVERMVQ 169
            ||||.|.|:..:|..|                   .||..||:|:.::|.| ||  ||.::....
Zfish    99 RCGVPDIRNYKTFDGD-------------------LKWDHTDVTYRILNYS-PDMEASLIDDAFA 143

  Fly   170 TALDVWANHSKLTFREVYSDQADIQILFARRAHGDGYKFDGPGQVLAHAFYPGEGRGGDAHFDAD 234
            .|..||::.:.|||..::...|||.|.|.:..|||.|.|||...:||||:.||||..||||||.|
Zfish   144 RAFKVWSDVTPLTFTRLFDGIADIMISFGKLDHGDPYPFDGKDGLLAHAYPPGEGTQGDAHFDDD 208

  Fly   235 ETW-------------------------------------------------------------- 237
            |.|
Zfish   209 EYWTLGSGPAIQTRYGNAEGAMCHFPFLFEGTSYSTCTTEGRTDGLPWCSTTADYDKDKKFGFCP 273

  Fly   238 -----NFDGESDD---------------------------------------------------- 245
                 .|||.|::
Zfish   274 SELLFTFDGNSNEAPCVFPFVFDGKKYDSCTTEGRNDGYRWCSTTANFDTDKKYGFCPNRDTAVI 338

  Fly   246 ------------------------SHGTN----------------------------FLNVALHE 258
                                    |.|.|                            || ||.||
Zfish   339 GGNSEGEPCHFPFTFLGNTYSSCTSEGRNDGKLWCGTTSNYDTDKKWGFCPDRGYSLFL-VAAHE 402

  Fly   259 LGHSLGLAHSAIPDAVMFPWYQNNEVAGNLPDDDRYGIQQLYGTKEKTWGPY----KPQTTTTTT 319
            .||:|||.||.|.||:|:|.|:..| ...|..||..|||.|||.:.   ||.    :|:|||::.
Zfish   403 FGHALGLDHSNIKDALMYPMYKYVE-GFPLHRDDIDGIQYLYGPRT---GPEPTAPQPRTTTSSP 463

  Fly   320 TTTTMRAMIYRADKPAYWPWNNPSNNPNNDRNRARERQEEERRRQEKERRRQEEERRHQEEERRR 384
            ...|         ||      :||:.
Zfish   464 VVPT---------KP------SPSDK--------------------------------------- 474

  Fly   385 QVEERQRQEEERWRQEQERQEEENRRRKIEHKSQWERNPSKERNRPRERQEMERRRQEQERQEQE 449

Zfish   475 ----------------------------------------------------------------- 474

  Fly   450 RQEQEDRRRERERDRQLEWERRNRNGAREPVTPTANTTPRPTNKPYPTVHRQHHHHNKPRKPKPD 514
                                           |.||:||.:..                   |..|
Zfish   475 -------------------------------TTTASTTTQVV-------------------PSDD 489

  Fly   515 SC-MTYYDAISIIRGELFIFRGPYLWRIGTSGLYNGYPTEIRRHWSALPENLTKVDAVYENK-QR 577
            :| :..:|||:.|:.||..|:....|:|..:|...| |..|...|.|||   ..:::.:|:. .:
Zfish   490 ACQIKEFDAITEIQKELHFFKDGRYWKISGNGERKG-PFMISAKWPALP---AVINSAFEDHLTK 550

  Fly   578 QIVFFIGREYYVF--NSVMLAPGFPKPLASLGLPPTLTHIDASFVWGHNNRTYMTSGTLYWRIDD 640
            :|.||..|:::|:  |.|:    .|:.:..||||..|..::.|...| ..:..:.:|..:||:|.
Zfish   551 KIYFFSERQFWVYSGNDVL----GPRKIEKLGLPSDLDKVEGSMQRG-KGKVLLFNGENFWRLDV 610

  Fly   641 YTGQVELDYPR-DMSIWSGVGYNIDAAFQYLDGKTYFFKNLGYWEFNDDRM--KVAHARAKLSAR 702
            ....::..||| ..:.:.||..:....|.| .|..||.:...||..|..|.  :|.:.:..|
Zfish   611 KAQLIDRGYPRFTDAAFGGVPIDSHDVFLY-KGFFYFCRESFYWRMNAKRQVDRVGYVKYDL--- 671

  Fly   703 RWMQCA 708
              ::|:
Zfish   672 --LKCS 675

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mmp2	NP_995788.1	Peptidase_M10	143..301	CDD:278824	80/330 (24%)
		ZnMc_MMP	143..301	CDD:239805	80/330 (24%)
		HX	513..707	CDD:238046	55/200 (28%)
mmp9	NP_998288.1	PG_binding_1	37..95	CDD:366659	12/59 (20%)
		Peptidase_M10	116..444	CDD:334067	80/330 (24%)
		FN2	224..272	CDD:128373	0/47 (0%)
		FN2	282..330	CDD:128373	2/47 (4%)
		FN2	340..388	CDD:128373	3/47 (6%)
		HX	489..674	CDD:238046	55/199 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1565
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1075463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10201
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X44
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.920