DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mmp2 and mmp14a

DIOPT Version :9

Sequence 1:	NP_995788.1	Gene:	Mmp2 / 35997	FlyBaseID:	FBgn0033438	Length:	758	Species:	Drosophila melanogaster
Sequence 2:	NP_919397.1	Gene:	mmp14a / 373882	ZFINID:	ZDB-GENE-030901-1	Length:	574	Species:	Danio rerio

Alignment Length:	725	Identity:	203/725 - (28%)
Similarity:	287/725 - (39%)	Gaps:	236/725 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 YLMQFDYLPKSDLETGALRTEDQLKEAIRSLQSFGNITVTGEIDSATARLIQKPRCGVGDRRSAD 117
            :|.|:.|||..|:...|:|:...:..||.::|.|..:||||.:|.||...:|:|||||
Zfish    36 WLQQYGYLPPGDVRAQAIRSPKSINSAISAMQKFYGLTVTGTMDPATLSAMQRPRCGV------- 93

  Fly   118 SFSPDNLYHEIGSNVRVRRFALQGPKWSRTDLTWSMVNRSMPDASK--VERMVQTALDVWANHSK 180
               ||....|:.||:|.:|:..||.||.:.::|:|:.|.: |...:  ....::.|..||...:.
Zfish    94 ---PDKFGSELKSNLRKKRYVAQGSKWDKREVTFSIQNYT-PKVGERATHEAIKKAFRVWEAVTP 154

  Fly   181 LTFREVYSDQ--------ADIQILFARRAHGDGYKFDGPGQVLAHAFYPGEGRGGDAHFDADETW 237
            |.|||:...|        |||.:.||...|||...|||.|..||||::||.|.|||.|||..|.|
Zfish   155 LKFREIPYSQINGKVEKFADIMLFFAEGFHGDSTPFDGEGGFLAHAYFPGHGIGGDTHFDEAEPW 219

  Fly   238 NFDGESDDSHGTNFLNVALHELGHSLGLAHSAIPDAVMFPWYQ----NNEVAGNLPDDDRYGIQQ 298
            . .|..|......|| ||:|||||:|||.||..|.|:|.|:||    .|.|   ||:|||.||||
Zfish   220 T-TGNVDKGGNDVFL-VAVHELGHALGLEHSGDPSAIMAPFYQWMDTENFV---LPEDDRRGIQQ 279

  Fly   299 LYGTKEKTWGPYKPQTTTTTTTTTTMRAMIYRADKPAYWPWNNPSNNPNNDRNRARERQEEERRR 363
            :||...:                          |||
Zfish   280 IYGAGSE--------------------------DKP----------------------------- 289

  Fly   364 QEKERRRQEEERRHQEEERRRQVEERQRQEEERWRQEQERQEEENRRRKIEHKSQWERNPSKERN 428

Zfish   290 ----------------------------------------------------------------- 289

  Fly   429 RPRERQEMERRRQEQERQEQERQEQEDRRRERERDRQLEWERRNRNGAREPVTPTANTTPRPTNK 493
                                                                .|.|   |||
Zfish   290 ----------------------------------------------------QPPA---PRP--- 296

  Fly   494 PYPTVHRQHHHHNKPRKPK--PDSCMTYYDAISIIRGELFIFRGPYLWRIGTSGLYNGYPTEIRR 556
              ||        ..|.:|.  ||.|..::|.|:.:|||:|:|:..:.||:.......|||..|..
Zfish   297 --PT--------RTPDRPSFGPDICEGHFDTIAFLRGEMFVFKEKWFWRVRDGKPQQGYPMPIGH 351

  Fly   557 HWSALPENLTKVDAVYENKQRQIVFFIGREYYVFNSVMLAPGFPKPLASLGLPPTLTHIDASFVW 621
            .|..||.:   ::|.||....:.|||.|.:|:|||...:..|:||....||.......:||:..:
Zfish   352 FWKGLPPS---INAAYERNDGKFVFFKGDKYWVFNEAKMEEGYPKTFKELGTGLPRDKLDAAIFY 413

  Fly   622 GHNNRTYMTSGTLYWRIDDYTGQVELDYPRDMSIWSGVGYNIDAAFQYLDG-KTYFFKNLGYWEF 685
            .....||...||.|:|.::.:..|:.|||:|:.:|.||..|:..||...|| ..||:|...||:|
Zfish   414 TPTGNTYFFRGTKYYRFNEESRSVDSDYPKDIGVWQGVPDNVKGAFMSEDGANAYFYKANKYWKF 478

  Fly   686 NDDRMKVAHARAKLSARRWMQCARSANEVDDEQRWTAS----LVSE--GEETG-RSGSRELRINH 743
            |:.::||.....|.....||.|     |.::.:|...:    |:.|  |.|.| ..|:..:.|..
Zfish   479 NNQQLKVEPGFPKSVLTNWMGC-----EAEEPKRRAGTDEEVLIIEVDGSEGGAMGGAAAIVIPL 538

  Fly   744 FILSILLLAI 753
            |:|:.:|:.:
Zfish   539 FLLACVLVTL 548

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mmp2	NP_995788.1	Peptidase_M10	143..301	CDD:278824	74/171 (43%)
		ZnMc_MMP	143..301	CDD:239805	74/171 (43%)
		HX	513..707	CDD:238046	68/194 (35%)
mmp14a	NP_919397.1	PG_binding_1	34..86	CDD:279773	19/49 (39%)
		Peptidase_M10	116..282	CDD:278824	74/171 (43%)
		ZnMc_MMP	116..282	CDD:239805	74/171 (43%)
		HX	308..500	CDD:238046	68/194 (35%)
		DUF3377	503..574	CDD:288690	11/46 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	47	1.000	Domainoid score	I11983
eggNOG	1	0.900	-	-		E1_KOG1565
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1075463at2759
OrthoFinder	1	1.000	-	-		FOG0000840
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10201
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3504
SonicParanoid	1	1.000	-	-		X44
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.950