DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mmp2 and mmp2

DIOPT Version :9

Sequence 1:	NP_995788.1	Gene:	Mmp2 / 35997	FlyBaseID:	FBgn0033438	Length:	758	Species:	Drosophila melanogaster
Sequence 2:	NP_932333.1	Gene:	mmp2 / 337179	ZFINID:	ZDB-GENE-030131-9123	Length:	657	Species:	Danio rerio

Alignment Length:	791	Identity:	193/791 - (24%)
Similarity:	306/791 - (38%)	Gaps:	233/791 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MFSKYVLATLLALFAQSMCIQELSLPPEGSHSTAATRSKKAKTAISEDIMYNYLMQFDYLPKSDL 65
            :|....||:|....|.|..|:   .|.:   .||.|         .:::..:||.:|...||...
Zfish    16 VFLVQFLASLQTFAAPSPIIK---FPGD---DTAHT---------DKEVALHYLNKFYGCPKDRC 65

  Fly    66 ETGALRTEDQLKEAIRSLQSFGNITVTGEIDSATARLIQKPRCGVGDRRSADSFSPD----NLYH 126
            ....      ||:.::.:|.|..:..|||||..|..:::||||||          ||    |.:|
Zfish    66 NLMV------LKDTLKKMQKFFALPETGEIDQKTVEIMKKPRCGV----------PDVANYNFFH 114

  Fly   127 EIGSNVRVRRFALQGPKWSRTDLTWSMVNRSMPDASK--VERMVQTALDVWANHSKLTFREVYSD 189
                         :.|||.:.::|:.::..: ||..:  ::.....|..||::.:.|.|..:...
Zfish   115 -------------RKPKWGQKNVTYRILGHT-PDLDEDTIDDAFYRAFKVWSDVTPLKFTRIMDG 165

  Fly   190 QADIQILFARRAHGDGYKFDGPGQVLAHAFYPGEGRGGDAHFDADETW-------------NFDG 241
            :|||.|.|.|..|||||.|||...:|||||.||.|.|||:|||.||.|             |.:|
Zfish   166 EADIMINFGRNEHGDGYPFDGKDGLLAHAFAPGPGIGGDSHFDDDEQWTLGEGQVVKVKYGNAEG 230

  Fly   242 E--------------------SDD-----SHGTNF-----LNVALHELGHSLGLAHSAIPDAVMF 276
            |                    .||     |...||     .....|||..:||......|  ..|
Zfish   231 EFCKFPFLFMGKEYNSCTSQGRDDGFLWCSTTYNFDDDGKYGFCPHELLFTLGGNADGAP--CKF 293

  Fly   277 PW------YQNNEVAGNLPDDDRY---GIQQLYGTKEKTWGPYKPQTTTTTTTTTTMRAMIYRAD 332
            |:      |.:...:|.   ||.|   ...:.| .|:||:| :.|:|..:|:...:..|
Zfish   294 PFTFQGDKYDSCTTSGR---DDGYRWCATTEDY-DKDKTYG-FCPETAMSTSGGNSDGA------ 347

  Fly   333 KPAYWPWNNPSNNPNNDRNRARERQEEERRRQEKERRRQEEERRHQEEERRRQVEERQRQEEERW 397
             |..:|:....::.::.....                                     |.:.:.|
Zfish   348 -PCVFPFKFLGDSYDSCTTSG-------------------------------------RNDGKMW 374

  Fly   398 RQEQERQEEENRRRKIEHKSQWERNPSKERNRPRERQEMERRRQEQERQEQERQEQEDRR----- 457
            ....:..:::.:         |...|                               |:.
Zfish   375 CAVTKSFDDDRK---------WGFCP-------------------------------DQGYSLFL 399

  Fly   458 -RERERDRQLEWERRNRNGAREPVTPTANTTPR---------------PTNKPYPTVHRQHHHHN 506
             ...|....|..|..:..||......|...|.|               ||:||..|       |.
Zfish   400 VAAHEFGHALGLEHSDDPGALMAPIYTFTKTLRLSDDDVKGIQELYGEPTDKPLAT-------HT 457

  Fly   507 KPRKPKPDSC--MTYYDAISIIRGELFIFRGPYLWRIGTSGLYNGYPTEIRRHWSALPENLTKVD 569
            .|..|. |.|  ...:||::.||||:|.|:..:|:|..........|..:...||.|||   |:|
Zfish   458 PPVTPM-DVCNENIIFDAVAQIRGEIFFFKDRFLFRTADVRKKPTGPMLVATFWSELPE---KID 518

  Fly   570 AVYENK-QRQIVFFIGREYYVFNSVMLAPGFPKPLASLGLPPTLTHIDASFVWGHNNRTYMTSGT 633
            |.|||. :.:.|||.|.|.:|:::..|...:||.::|:|||..|..|||::.:....:||:.:|.
Zfish   519 AAYENPLEERTVFFAGDEMWVYSASTLEREYPKKISSMGLPSDLHGIDAAYSFHKTKKTYIFAGN 583

  Fly   634 LYWRIDDYTGQVELDYPRDMS-IWSGVGYNIDAAFQYL-DGKTYFFKNLGYWEFNDDRMKVAHAR 696
            .:||.::...:::..:|:.:: .|:.|..::|.|.... ||.:||||:..|.:.:|..:|:  .:
Zfish   584 KFWRYNEAKKKMDPGFPKIIADSWTAVPDDLDGALSLNGDGHSYFFKDSHYLKMDDSTLKI--IK 646

  Fly   697 AKLSARRWMQC 707
            .....:.|::|
Zfish   647 VGEVKKDWLRC 657

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mmp2	NP_995788.1	Peptidase_M10	143..301	CDD:278824	62/211 (29%)
		ZnMc_MMP	143..301	CDD:239805	62/211 (29%)
		HX	513..707	CDD:238046	61/198 (31%)
mmp2	NP_932333.1	PG_binding_1	<70..97	CDD:366659	10/26 (38%)
		Peptidase_M10	118..446	CDD:334067	86/419 (21%)
		FN2	226..274	CDD:128373	8/47 (17%)
		FN2	284..332	CDD:128373	13/54 (24%)
		FN2	342..390	CDD:128373	6/100 (6%)
		HX	463..657	CDD:238046	61/199 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1565
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1075463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10201
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X44
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.920