Protein Alignment Mmp2 and Mmp20

DIOPT Version :9

• Sequence 1: NP_995788.1
• Gene: Mmp2 / 35997
• FlyBaseID: FBgn0033438
• Length: 758
• Species: Drosophila melanogaster
• Sequence 2: NP_038931.1
• Gene: Mmp20 / 30800
• MGIID: 1353466
• Length: 482
• Species: Mus musculus
• Alignment Length: 690
• Identity: 169/690 - (24%)
• Similarity: 241/690 - (34%)
• Gaps: 243/690 - (35%)

  Fly    35 ATRSKKAKTAISEDIMYNYLMQFDYLPKSDLETG-------ALRTEDQLKEAIRSLQSFGNITVT 92
            ||.......|.......||.:...||.|...:.|       ..|..:.:...|:.||.|..:.||
Mouse    19 ATADPNLLAATPRTFRSNYHLAQAYLDKYYTKKGGPQAGEMVARESNPMIRRIKELQIFFGLKVT 83

  Fly    93 GEIDSATARLIQKPRCGVGDRRSADSFSPDNLYHEIGSNVRVRRFALQGPKWSRTDLTWSMVNRS 157
            |::|..|..:|:||||||.|..:...|..:                   |||.:..||: .:::.
Mouse    84 GKLDQNTMNVIKKPRCGVPDVANYRLFPGE-------------------PKWKKNILTY-RISKY 128

  Fly   158 MPDAS--KVERMVQTALDVWANHSKLTFREVYSDQADIQILFARRAHGDGYKFDGPGQVLAHAFY 220
            .|..|  :|::.:|.||..|:....|.|..:.|.:|||.|.|....|||.|.||||...|||||.
Mouse   129 TPSMSPTEVDKAIQMALHAWSTAVPLNFVRINSGEADIMISFETGDHGDSYPFDGPRGTLAHAFA 193

  Fly   221 PGEGRGGDAHFDADETWNFDGESDDSHGTNFLNVALHELGHSLGLAHSAIPDAVMFPWYQ-NNEV 284
            ||||.|||.|||..|.|..     .::|.|...||.||.||:|||.||..|.|:|:|.|: .|..
Mouse   194 PGEGLGGDTHFDNAEKWTM-----GTNGFNLFTVAAHEFGHALGLGHSTDPSALMYPTYKYQNPY 253

  Fly   285 AGNLPDDDRYGIQQLYGTKEKTWGPYKPQTTTTTTTTTTMRAMIYRADKPAYWPWNNPSNNPNND 349
            ..:||.||..|||.|||
Mouse   254 RFHLPKDDVKGIQALYG------------------------------------------------ 270

  Fly   350 RNRARERQEEERRRQEKERRRQEEERRHQEEERRRQVEERQRQEEERWRQEQERQEEENRRRKIE 414
                                                                             
Mouse   271 ----------------------------------------------------------------- 270

  Fly   415 HKSQWERNPSKERNRPRERQEMERRRQEQERQEQERQEQEDRRRERERDRQLEWERRNRNGAREP 479
                           ||:
Mouse   271 ---------------PRK----------------------------------------------- 273

  Fly   480 VTPTANTTPRPTNKPYPTVHRQHHHHNKPRKPK-PDSC--MTYYDAISIIRGELFIFRGPYLWRI 541
            :.|...|.|                |..|.||. ||.|  .:.:||::::..||..|:....||.
Mouse   274 IFPGKPTMP----------------HIPPHKPSIPDLCDSSSSFDAVTMLGKELLFFKDRIFWRR 322

  Fly   542 GTSGLYNGYPTEIRRH--WSALPENLTKVDAVYENKQRQIVFFI-GREYYVFNSVMLAPGFPKPL 603
            ...     .||.||..  .|:.|:.::.|||.||..:|.|.||. |..|:|.....: .|.|:.:
Mouse   323 QVH-----LPTGIRPSTITSSFPQLMSNVDAAYEVAERGIAFFFKGPHYWVTRGFHM-QGPPRTI 381

  Fly   604 ASLGLPPTLTHIDASFVWGHNNRTYMTSGTLYWRIDDYTGQVELDYPRDM-SIWSGVGYNIDAAF 667
            ...|.|..:..|||:.......:|....|..|:..|:...::|.|||::. ..:|||..:||||.
Mouse   382 YDFGFPRHVQRIDAAVYLKEPQKTLFFVGEEYYSYDERKKKMEKDYPKNTEEEFSGVSGHIDAAV 446

  Fly   668 QYLDGKTYFFKNLGYWEFNDDRMKVAHARAKLSARRWMQC 707
            : |:|..|||.....::::.::..|.   :.:.:..|:.|
Mouse   447 E-LNGYIYFFSGRKTFKYDTEKEDVV---SVVKSSSWIGC 482

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mmp2	NP_995788.1	Peptidase_M10	143..301	CDD:278824	71/160 (44%)
		ZnMc_MMP	143..301	CDD:239805	71/160 (44%)
		HX	513..707	CDD:238046	57/199 (29%)
Mmp20	NP_038931.1	PG_binding_1	39..94	CDD:279773	14/54 (26%)
		Cysteine switch. /evidence=ECO:0000250	97..104		5/6 (83%)
		Peptidase_M10	115..270	CDD:278824	71/160 (44%)
		ZnMc_MMP	115..270	CDD:239805	71/160 (44%)
		HX	292..482	CDD:238046	57/199 (29%)
		Hemopexin 1	292..342		16/54 (30%)
		Hemopexin 2	343..388		15/45 (33%)
		Hemopexin 3	390..438		12/47 (26%)
		Hemopexin 4	439..482		11/46 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	149	1.000	Domainoid score	I4394
eggNOG	1	0.900	-	-		E1_KOG1565
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1075463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10201
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X44
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.920