Protein Alignment Mmp2 and Mmp20

DIOPT Version :10

• Sequence 1: NP_995788.1
• Gene: Mmp2 / 35997
• FlyBaseID: FBgn0033438
• Length: 758
• Species: Drosophila melanogaster
• Sequence 2: NP_001100270.1
• Gene: Mmp20 / 300341
• RGDID: 1308730
• Length: 482
• Species: Rattus norvegicus
• Alignment Length: 690
• Identity: 170/690 - (24%)
• Similarity: 241/690 - (34%)
• Gaps: 243/690 - (35%)

  Fly    35 ATRSKKAKTAISEDIMYNYLMQFDYLPKSDLETG-------ALRTEDQLKEAIRSLQSFGNITVT 92
            ||.:.....|.......||.:...||.|...:.|       ..|..:.....|:.||:|..:.||
  Rat    19 ATAAPALLAATPRTFRSNYHLAQAYLDKYYTKKGGPQAGEMVARESNPTVRKIKELQTFFGLRVT 83

  Fly    93 GEIDSATARLIQKPRCGVGDRRSADSFSPDNLYHEIGSNVRVRRFALQGPKWSRTDLTWSMVNRS 157
            |::|..|..:|::|||||.|..:...|..:                   |||.:..||: .|::.
  Rat    84 GKLDQNTMDVIKRPRCGVPDVANYRLFPGE-------------------PKWKKNILTY-RVSKY 128

  Fly   158 MPDAS--KVERMVQTALDVWANHSKLTFREVYSDQADIQILFARRAHGDGYKFDGPGQVLAHAFY 220
            .|..|  :|::.|..||..|:....|.|..:.|.:|||.|.|....|||.|.||||...|||||.
  Rat   129 TPSMSPTEVDKAVHMALHAWSTAVPLIFVRINSGEADIMISFETGDHGDSYPFDGPRGTLAHAFA 193

  Fly   221 PGEGRGGDAHFDADETWNFDGESDDSHGTNFLNVALHELGHSLGLAHSAIPDAVMFPWYQ-NNEV 284
            ||||.|||.|||..|.|..     .::|.|...||.||.||:|||.||..|.|:|:|.|: .|..
  Rat   194 PGEGLGGDTHFDNAEKWTM-----GTNGFNLFTVAAHEFGHALGLGHSTDPSALMYPTYKYQNPY 253

  Fly   285 AGNLPDDDRYGIQQLYGTKEKTWGPYKPQTTTTTTTTTTMRAMIYRADKPAYWPWNNPSNNPNND 349
            ..:||.||..|||.|||.: ||: |.||
  Rat   254 RFHLPKDDVKGIQALYGPR-KTF-PGKP------------------------------------- 279

  Fly   350 RNRARERQEEERRRQEKERRRQEEERRHQEEERRRQVEERQRQEEERWRQEQERQEEENRRRKIE 414
                                                                             
  Rat   280 ----------------------------------------------------------------- 279

  Fly   415 HKSQWERNPSKERNRPRERQEMERRRQEQERQEQERQEQEDRRRERERDRQLEWERRNRNGAREP 479
                                                                             
  Rat   280 ----------------------------------------------------------------- 279

  Fly   480 VTPTANTTPRPTNKPYPTVHRQHHHHNKPRKPK-PDSC--MTYYDAISIIRGELFIFRGPYLWRI 541
                  |.|                |..|.||. ||.|  .:.:||::::..||..|:....||.
  Rat   280 ------TMP----------------HIPPHKPSIPDLCDSSSSFDAVTMLGKELLFFKDRIFWRR 322

  Fly   542 GTSGLYNGYPTEIRRH--WSALPENLTKVDAVYENKQRQIVFFI-GREYYVFNSVMLAPGFPKPL 603
            ...     .|..||..  .|:.|:.::.|||.||..:|.|.||. |..|:|.....: .|.|:.:
  Rat   323 RVH-----LPAGIRPSTITSSFPQLMSNVDAAYEVAERGIAFFFKGPHYWVTRGFQM-QGPPRTI 381

  Fly   604 ASLGLPPTLTHIDASFVWGHNNRTYMTSGTLYWRIDDYTGQVELDYPRDM-SIWSGVGYNIDAAF 667
            ...|.|..:..|||:.......:|....|..|:..|:...::|.|||:.. ..:|||..:||||.
  Rat   382 YDFGFPRHVQRIDAAVYLKEPQKTLFFVGEEYYSYDERKKKMEKDYPKSTEEEFSGVSGHIDAAV 446

  Fly   668 QYLDGKTYFFKNLGYWEFNDDRMKVAHARAKLSARRWMQC 707
            : |:|..|||.....::::.::..|.   :.:.:..|:.|
  Rat   447 E-LNGYIYFFSGPKTFKYDTEKEDVV---SVVKSSSWVGC 482

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mmp2	NP_995788.1	PG_binding_1	52..103	CDD:460223	16/57 (28%)
		Peptidase_M10	143..301	CDD:425668	72/160 (45%)
		HX	513..707	CDD:238046	56/199 (28%)
Mmp20	NP_001100270.1	PG_binding_1	39..94	CDD:460223	14/54 (26%)
		Peptidase_M10	115..270	CDD:425668	72/160 (45%)
		HX	292..464	CDD:238046	54/178 (30%)