Protein Alignment Mmp2 and Mmp27

DIOPT Version :10

• Sequence 1: NP_995788.1
• Gene: Mmp2 / 35997
• FlyBaseID: FBgn0033438
• Length: 758
• Species: Drosophila melanogaster
• Sequence 2: NP_001100269.1
• Gene: Mmp27 / 300340
• RGDID: 1306642
• Length: 511
• Species: Rattus norvegicus
• Alignment Length: 692
• Identity: 164/692 - (23%)
• Similarity: 243/692 - (35%)
• Gaps: 246/692 - (35%)

  Fly    32 STAATRSKKAKTAISEDIMYNYLMQFDYLPKSDLETGAL---RTEDQLKEAIRSLQSFGNITVTG 93
            |:|....:|.|...:..:...||.||..|   ::|...|   :....|...::.:|:|..:||||
  Rat    15 SSAFLPDRKDKNEENNQLAQAYLNQFYSL---EIEGSHLVQSKNRSLLDGKLQEMQAFFGLTVTG 76

  Fly    94 EIDSATARLIQKPRCGVGDRRSADSFSPDNLYHEIGSNVRVRRFALQGPKWSRTDLTWSMVNRSM 158
            ::||.|..:::.|||||.|                     |.::....|.|.:.:||:.::|.:
  Rat    77 KLDSDTLEIMKVPRCGVPD---------------------VGQYGYTLPGWRKYNLTYRIMNYT- 119

  Fly   159 PDA--SKVERMVQTALDVWANHSKLTFREVYSDQADIQILFARRAHG-DGYKFDGPGQVLAHAFY 220
            ||.  :.|:..:|.||.||:..:.|.|..:....|||.|.|..|.|| ....||||..||.|||.
  Rat   120 PDMTHADVDEAIQKALQVWSKVTPLMFTRISKGVADIMIAFRTRVHGWCPRHFDGPLGVLGHAFP 184

  Fly   221 PGEGRGGDAHFDADETWNFDGESDDSHGTNFLNVALHELGHSLGLAHSAIPDAVMFPWYQN---N 282
            ||.|.|||.|||.||||.    :.|..|.|...||.||.||||||:||:...|:|||.|.:   |
  Rat   185 PGLGLGGDTHFDEDETWT----TGDGEGFNLFLVAAHEFGHSLGLSHSSDQTALMFPNYVSLDPN 245

  Fly   283 EVAGNLPDDDRYGIQQLYGTKEKTWGPYKPQTTTTTTTTTTMRAMIYRADKPAYWPWNNPSNNPN 347
            :..  |..||..|||.:||
  Rat   246 KYP--LSQDDINGIQSIYG---------------------------------------------- 262

  Fly   348 NDRNRARERQEEERRRQEKERRRQEEERRHQEEERRRQVEERQRQEEERWRQEQERQEEENRRRK 412
                                                                             
  Rat   263 ----------------------------------------------------------------- 262

  Fly   413 IEHKSQWERNPSKERNRPRERQEMERRRQEQERQEQERQEQEDRRRERERDRQLEWERRNRNGAR 477
                     :|||...:|                                           ||..
  Rat   263 ---------SPSKVPTKP-------------------------------------------NGNP 275

  Fly   478 EPVTPTANTTPRPTNKPYPTVHRQHHHHNKPRKPKPDSCMTYYDAISIIRGELFIFRGPYLWRIG 542
            .|.....|.|                                :||::..|.|:...:|.:|||:.
  Rat   276 VPCACEPNLT--------------------------------FDAVTTFRREIMFLKGRHLWRVY 308

  Fly   543 TSGLYNGYPTE-IRRHWSALPENLTKVDAVYENKQRQIVFFIGREYYVFNSVMLAPGFPKPLASL 606
            :.  ..|...| |...|.:||.:|   .|.||:.:.:::.|....::|.....:.||:||.:.:|
  Rat   309 SD--ITGAEFEFIDSFWPSLPADL---QAAYESPRDEVLVFKDENFWVIRGNSVLPGYPKSIHTL 368

  Fly   607 GLPPTLTHIDASFVWGHNNRTYMTSGTLYWRIDDYTGQVELDYP-RDMSIWSGVGYNIDAAFQYL 670
            |.|..:..|||:.......:|:...|...||.|:....::..:| |.|..:.|:...:||.|| .
  Rat   369 GFPRRVKKIDAAVCDHDTKKTFFFVGIWCWRYDEMAQAMDRGFPQRIMKRFPGIRLRVDAVFQ-R 432

  Fly   671 DGKTYFFKNLGYWEFNDDRMKVAHARAKLSARRWMQCARSAN 712
            :|..|||:....:|::   ||..:....:....|..|....|
  Rat   433 NGFFYFFRGSRQFEYD---MKAKNITQVMKTNTWFLCNEPLN 471

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mmp2	NP_995788.1	PG_binding_1	52..103	CDD:460223	17/53 (32%)
		Peptidase_M10	143..301	CDD:425668	71/163 (44%)
		HX	513..707	CDD:238046	51/195 (26%)
Mmp27	NP_001100269.1	PG_binding_1	31..86	CDD:460223	17/57 (30%)
		Peptidase_M10	106..262	CDD:425668	71/162 (44%)
		HX	277..466	CDD:238046	54/229 (24%)