Protein Alignment Mmp2 and Mmp17

DIOPT Version :10

• Sequence 1: NP_995788.1
• Gene: Mmp2 / 35997
• FlyBaseID: FBgn0033438
• Length: 758
• Species: Drosophila melanogaster
• Sequence 2: NP_001099395.1
• Gene: Mmp17 / 288626
• RGDID: 1311541
• Length: 587
• Species: Rattus norvegicus
• Alignment Length: 725
• Identity: 211/725 - (29%)
• Similarity: 305/725 - (42%)
• Gaps: 214/725 - (29%)

  Fly    23 LSLPPEGSHSTAATRSKKAKTAISEDIMYNYLMQFDYLPKSDLETGALRTEDQLKEAIRSLQSFG 87
            |:|...|..:..|.|::.....:      .:|.:|.|||.:|..||.|:|:::|.:||.::|.||
  Rat    30 LALAAHGGCAAPAPRAEDLSLGV------EWLSKFGYLPPADPATGQLQTQEELSKAITAMQQFG 88

  Fly    88 NITVTGEIDSATARLIQKPRCGVGDRRSADSFSPDNLYHEIGSNVRVRRFALQGPKWSRTDLTWS 152
            .:..||.:|.||..|::.|||.:.|.             .:|:..|.||......|||:.:|:|.
  Rat    89 GLETTGILDEATLALMKTPRCSLPDL-------------PLGAQSRRRRQTPLPTKWSKRNLSWR 140

  Fly   153 MVNRSMPDASKVER-----MVQTALDVWANHSKLTFREVYSDQADIQILFARRAHGDGYKFDGPG 212
            :  |:.|..|.:.|     ::..||.||::.:.|.|.||..:.|||||.|::..|.|||.|||||
  Rat   141 V--RTFPRDSPLGRDTVRALMYYALKVWSDITPLNFHEVAGNMADIQIDFSKADHNDGYPFDGPG 203

  Fly   213 QVLAHAFYPGEGR-GGDAHFDADETWNFDGESDDSHGTNFLNVALHELGHSLGLAHSAIPDAVMF 276
            ..:||||:||:.. .||.|||.||.|.|  .|.|:||.:...||:||.||::||:|.|.|.::|.
  Rat   204 GTVAHAFFPGDHHTAGDTHFDDDEAWTF--RSSDAHGMDLFAVAVHEFGHAIGLSHVAAPSSIMQ 266

  Fly   277 PWYQNNEVAGNLPDDDRYGIQQLYGTKEKTWGPYKPQTTTTTTTTTTMRAMIYRADKPAYWPWNN 341
            |:||     |.:.|..|||:            ||
  Rat   267 PYYQ-----GPVGDPLRYGL------------PY------------------------------- 283

  Fly   342 PSNNPNNDRNRARERQEEERRRQEKERRRQEEERRHQEEERRRQVEERQRQEEERWRQEQERQEE 406
                                                                             
  Rat   284 ----------------------------------------------------------------- 283

  Fly   407 ENRRRKIEHKSQWERNPSKERNRPRERQEMERRRQEQERQEQERQEQEDRRRERERDRQLEWERR 471
                                                           |||.|        .|:
  Rat   284 -----------------------------------------------EDRVR--------VWQ-- 291

  Fly   472 NRNGAREPVTPTAN-TTPRPTNKPYPTVHRQHHHHNKPRKPKPDSCMTYYDAISIIRGELFIFRG 535
             ..|.||.|:|||. .||.|...|.......:.....|:|..|..|..::||::.||||.|.|:|
  Rat   292 -LYGVRESVSPTAQLDTPEPEEPPLLPEPPNNRSSTPPQKDVPHRCTAHFDAVAQIRGEAFFFKG 355

  Fly   536 PYLWRIGTS-GLYNGYPTEIRRHWSALPENLTKVDAVYE-NKQRQIVFFIGREYYVFNSVMLAPG 598
            .|.||:... .|.:..|.::.|.|..||.:|..|||||| ....:||||.|..|:||....:..|
  Rat   356 KYFWRLTRDRHLVSLQPAQMHRFWRGLPLHLDSVDAVYERTSDHKIVFFKGDRYWVFKDNNVEEG 420

  Fly   599 FPKPLASLGLPPTLTHIDASFVWGHNNRTYMTSGTLYWRIDDYTGQVELDYPRDMSIWSGVGYNI 663
            :|:|::...|||  ..|||.|.|.||:|||.....||||.||:|.:::..||....:|.||...:
  Rat   421 YPRPVSDFSLPP--GGIDAVFSWAHNDRTYFFKDQLYWRYDDHTRRMDPGYPAQGPLWRGVPSVL 483

  Fly   664 DAAFQYLDGKTYFFKNLGYWEFNDDRMKVAHARAKLSARRWMQCARSANEVDDEQRWTASLVSEG 728
            |.|.::.||.:|||:...||:..|..::.|....:.:||.|:.|.....:.:|        |..|
  Rat   484 DDAMRWSDGASYFFRGQEYWKVLDGELEAAPGYPQSTARDWLVCGEQLADAED--------VGPG 540

  Fly   729 EETGRSGSRE 738
            .: ||||:::
  Rat   541 PQ-GRSGAQD 549

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mmp2	NP_995788.1	PG_binding_1	52..103	CDD:460223	21/50 (42%)
		Peptidase_M10	143..301	CDD:425668	71/163 (44%)
		HX	513..707	CDD:238046	77/195 (39%)
Mmp17	NP_001099395.1	PG_binding_1	44..104	CDD:460223	22/65 (34%)
		ZnMc_MMP	131..294	CDD:239805	78/337 (23%)
		HX	333..527	CDD:238046	77/195 (39%)