Protein Alignment Mmp2 and Mmp11

DIOPT Version :9

• Sequence 1: NP_995788.1
• Gene: Mmp2 / 35997
• FlyBaseID: FBgn0033438
• Length: 758
• Species: Drosophila melanogaster
• Sequence 2: NP_037112.2
• Gene: Mmp11 / 25481
• RGDID: 3099
• Length: 491
• Species: Rattus norvegicus
• Alignment Length: 614
• Identity: 179/614 - (29%)
• Similarity: 233/614 - (37%)
• Gaps: 216/614 - (35%)

  Fly   107 RCGVGDRRSADSFSPDNLYHEIGSNVRVRRFALQGPKWSRTDLT-------WSMVNRSMPDASKV 164
            ||||.|       .||.|    .:..|.:||.|.|.:|.:||||       |.:|.      .:|
  Rat    83 RCGVPD-------PPDVL----NARNRQKRFVLSGGRWEKTDLTYRILRFPWQLVR------EQV 130

  Fly   165 ERMVQTALDVWANHSKLTFREVYSDQADIQILFARRAHGDGYKFDGPGQVLAHAFYPGEGRGGDA 229
            .:.|..||.||:..:.|||.||:..:|||.|.|.|..|||...|||||.:|||||:|...|.||.
  Rat   131 RQTVAEALRVWSEVTPLTFTEVHEGRADIMIDFTRYWHGDNLPFDGPGGILAHAFFPKTHREGDV 195

  Fly   230 HFDADETWNFDGESDDSHGTNFLNVALHELGHSLGLAHSAIPDAVMFPWYQNNEVAGNLPDDDRY 294
            |||.||||....:     ||:.|.||.||.||.|||.|:....|:|.|:| ......:|..|||.
  Rat   196 HFDYDETWTIGDK-----GTDLLQVAAHEFGHVLGLQHTTAAKALMSPFY-TFRYPLSLSPDDRR 254

  Fly   295 GIQQLYGTKEKTWGPYKPQTTTTTTTTTTMRAMIYRADKPAYWPWNNPSNNPNNDRNRARERQEE 359
            |||.|||         :||.|.|:.|.|.                   |:....|.|..
  Rat   255 GIQHLYG---------RPQLTPTSPTPTL-------------------SSQAGTDTNEI------ 285

  Fly   360 ERRRQEKERRRQEEERRHQEEERRRQVEERQRQEEERWRQEQERQEEENRRRKIEHKSQWERNPS 424
                                                                             
  Rat   286 ----------------------------------------------------------------- 285

  Fly   425 KERNRPRERQEMERRRQEQERQEQERQEQEDRRRERERDRQLEWERRNRNGAREPVTPTANTTPR 489
                                                              ..:||..|
  Rat   286 --------------------------------------------------ALQEPEVP------- 293

  Fly   490 PTNKPYPTVHRQHHHHNKPRKPKPDSCMTYYDAISIIRGELFIFRGPYLWRIGTSGLYNGYPTEI 554
                                   |:.|.|.:||:|.||||||.|:..::||:.:..|..|||...
  Rat   294 -----------------------PEVCETSFDAVSTIRGELFFFKAGFVWRLRSGQLQPGYPALA 335

  Fly   555 RRHWSALPENLTKVDAVYENKQRQIVFFIGREYYVFNSVMLAPGFPKPLASLGLPPTLTHIDASF 619
            .|||..||   :.|||.:|:.|.||.||.|.:|:|::......| |.||:.|||..:..|  |:.
  Rat   336 SRHWQGLP---SPVDAAFEDAQGQIWFFQGAQYWVYDGEKPVLG-PAPLSKLGLQGSPVH--AAL 394

  Fly   620 VWG-HNNRTYMTSGTLYWRIDDYTGQVELDYPRDMSIWSGVGYNIDAAFQYLDGKTYFFKNLGYW 683
            ||| ..|:.|...|..|||....|.:|:...||..:.|.||...||||||..:|..||.:...||
  Rat   395 VWGPEKNKIYFFRGGDYWRFHPRTQRVDNPVPRRTTDWRGVPSEIDAAFQDAEGYAYFLRGHLYW 459

  Fly   684 EFNDDRMKVAHARAKLSARRWMQCARSAN 712
            :|:..::||..:..:.....:..||..||
  Rat   460 KFDPVKVKVLESFPRPIGPDFFDCAEPAN 488

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mmp2	NP_995788.1	Peptidase_M10	143..301	CDD:278824	73/164 (45%)
		ZnMc_MMP	143..301	CDD:239805	73/164 (45%)
		HX	513..707	CDD:238046	75/194 (39%)
Mmp11	NP_037112.2	Cysteine switch. /evidence=ECO:0000250	82..89		5/12 (42%)
		Peptidase_M10	108..261	CDD:395334	73/164 (45%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	260..279		9/46 (20%)
		HX	294..483	CDD:238046	75/194 (39%)
		Hemopexin 1	298..342		20/43 (47%)
		Hemopexin 2	343..385		18/45 (40%)
		Hemopexin 3	387..435		16/49 (33%)
		Hemopexin 4	436..483		14/46 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	148	1.000	Domainoid score	I4331
eggNOG	1	0.900	-	-		E1_KOG1565
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1075463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10201
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X44
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	7	6.880