DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mmp2 and Mmp7

DIOPT Version :9

Sequence 1:	NP_995788.1	Gene:	Mmp2 / 35997	FlyBaseID:	FBgn0033438	Length:	758	Species:	Drosophila melanogaster
Sequence 2:	NP_036996.1	Gene:	Mmp7 / 25335	RGDID:	3100	Length:	267	Species:	Rattus norvegicus

Alignment Length:	305	Identity:	121/305 - (39%)
Similarity:	163/305 - (53%)	Gaps:	48/305 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 ATLLALFAQSMCIQELSLPPEGSHSTAATRSKKAKTAISEDIMYNYLMQFDYL--PKSDLETGAL 70
            |..|.|| :.:|:    ||  |..:...::.....||:..:...|||.:| ||  .|:...|.|:
  Rat     3 AMRLTLF-RIVCL----LP--GCLALPLSQEAGEVTALQWEQAQNYLRKF-YLHDSKTKKATSAV 59

  Fly    71 RTEDQLKEAIRSLQSFGNITVTGEIDSATARLIQKPRCGVGDRRSADSFSPDNLYHEIGSNVRVR 135
               |:|:|    :|.|..:..||::......::|||||||.|                     |.
  Rat    60 ---DKLRE----MQKFFGLPETGKLSPRVMEIMQKPRCGVPD---------------------VA 96

  Fly   136 RFAL--QGPKWSRTDLTWSMVNRSMPDASK--VERMVQTALDVWANHSKLTFREVYSDQADIQIL 196
            .|:|  ..|||....:|:.:|:.: .|..:  |:::|:.||.:|:....|.|:.|....|||.|.
  Rat    97 EFSLMPNSPKWHSRTVTYRIVSYT-TDLPRFLVDQIVKRALRMWSMQIPLNFKRVSWGTADIIIG 160

  Fly   197 FARRAHGDGYKFDGPGQVLAHAFYPGEGRGGDAHFDADETWNFDGESDDSHGTNFLNVALHELGH 261
            |||..|||.:.|||||..|.|||.||.|.|||||||.||.|. |||  || |.|||.||.|||||
  Rat   161 FARGDHGDNFPFDGPGNTLGHAFAPGPGLGGDAHFDKDEYWT-DGE--DS-GVNFLFVATHELGH 221

  Fly   262 SLGLAHSAIPDAVMFPWYQNNEVAG-NLPDDDRYGIQQLYGTKEK 305
            ||||.||::|.:||:|.||.:.... :|..||..|||:|||.:.|
  Rat   222 SLGLGHSSVPSSVMYPTYQGDHSEDFSLTKDDIAGIQKLYGKRNK 266

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mmp2	NP_995788.1	Peptidase_M10	143..301	CDD:278824	80/160 (50%)
		ZnMc_MMP	143..301	CDD:239805	80/160 (50%)
		HX	513..707	CDD:238046
Mmp7	NP_036996.1	PG_binding_1	34..85	CDD:396175	16/58 (28%)
		Cysteine switch. /evidence=ECO:0000250	88..95		6/27 (22%)
		Peptidase_M10	106..262	CDD:395334	80/160 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	148	1.000	Domainoid score	I4331
eggNOG	1	0.900	-	-		E1_KOG1565
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1075463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10201
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X44
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.920