DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mmp2 and Mmp25

DIOPT Version :9

Sequence 1:NP_995788.1 Gene:Mmp2 / 35997 FlyBaseID:FBgn0033438 Length:758 Species:Drosophila melanogaster
Sequence 2:NP_001028511.1 Gene:Mmp25 / 240047 MGIID:2443938 Length:615 Species:Mus musculus


Alignment Length:668 Identity:191/668 - (28%)
Similarity:272/668 - (40%) Gaps:208/668 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    53 YLMQFDYLPKSDLETGALRTEDQLKEAIRSLQSFGNITVTGEIDSATARLIQKPRCGVGDRRSAD 117
            :|.::.|||.:|.....:::.::|::||:.:|.|..:..||::|..|.:.::||||.:.|...| 
Mouse    90 WLTRYGYLPPADPVHAQMQSLEKLQDAIKVMQRFAGLPETGQMDPMTIKTMRKPRCSLPDVLGA- 153

  Fly   118 SFSPDNLYHEIGSNVRVRRFALQGPKWSRTDLTWSMVNRSMPDASK-----VERMVQTALDVWAN 177
                      .|...|.||::|.|..|.:..||||:  ||....|:     |..::..||.|||.
Mouse   154 ----------AGLVRRRRRYSLSGSVWKKRTLTWSI--RSFSQKSQLSPQIVRTLLSYALAVWAT 206

  Fly   178 HSKLTFREVYS--DQADIQILFARRAHGDGYKFDGPGQVLAHAFYPGEGR-GGDAHFDADETWNF 239
            .|.|||:||.|  .:.||.|.|||..|.|.|.|||.|..|||||:|||.. .||.|||.:|||.|
Mouse   207 ESGLTFQEVNSQYQEPDIIIHFARAYHQDSYPFDGSGGTLAHAFFPGEHPISGDTHFDDEETWTF 271

  Fly   240 DGESDDSHGTNFLNVALHELGHSLGLAHSAIPDAVMFPWYQ---NNEVAGNLPDDDRYGIQQLYG 301
             |.:|| :|.:...||:||.||:|||.||:.|:::|.|:||   .:.....||.|||.|:|||||
Mouse   272 -GSTDD-NGIDLFAVAVHEFGHALGLGHSSAPNSIMRPFYQGPVGDPATYRLPQDDRDGLQQLYG 334

  Fly   302 TKEKTWGPYKPQTTTTTTTTTTMRAMIYRADKPAYWPWNNPSNNPNNDRNRARERQEEERRRQEK 366
                                                   ..|.|||                   
Mouse   335 ---------------------------------------RVSQNPN------------------- 341

  Fly   367 ERRRQEEERRHQEEERRRQVEERQRQEEERWRQEQERQEEENRRRKIEHKSQWERNPSKERNRPR 431
                                                                         .|| 
Mouse   342 -------------------------------------------------------------ARP- 344

  Fly   432 ERQEMERRRQEQERQEQERQEQEDRRRERERDRQLEWERRNRNGAREPVTPTANTTPRPTNKPYP 496
                                                        .|:|:.|    .|:|...|  
Mouse   345 --------------------------------------------TRKPLVP----PPQPPAMP-- 359

  Fly   497 TVHRQHHHHNKPRKPKPDSCMTYYDAISIIRGELFIFRGPYLWRIGTSG-LYNGYPTEIRRHWSA 560
                    .:.|..|.||.|...:||::.||||:|:|:||:.||:..|| |.:..|..:.|.|..
Mouse   360 --------PDSPATPVPDRCEGNFDAVANIRGEIFLFKGPWFWRLQPSGQLVSPRPAGLHRFWEG 416

  Fly   561 LPENLTKVDAVYENK-QRQIVFFIGREYYVFNSVMLAPGFPKPLASLGLPPTLTHIDASFVWGHN 624
            ||.::..:.|.|... ..:|:.|.|.:::||....| .|..:||...||||. ..:||.|.|.||
Mouse   417 LPTHVKVIQAAYARPLDGRIILFSGPQFWVFQERQL-EGAARPLVEFGLPPG-EDVDAVFSWPHN 479

  Fly   625 NRTYMTSGTLYWRIDDYTGQVELDYPRDMSIWSGVGYNIDAAFQYLDGKTYFFKNLGYWEFNDDR 689
            .:||:..|..|||.|:...:.:..|||.:|:|.|..:..|.......|.|||||...:|.|.:..
Mouse   480 GKTYLIRGQKYWRYDEVAARPDPGYPRALSLWDGAPFAPDDVTISNTGDTYFFKGTHFWRFAEGS 544

  Fly   690 MKVAHARAKLSARRWMQC 707
            :|......:....:|:.|
Mouse   545 VKAESDSPQPIGPKWLDC 562

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Mmp2NP_995788.1 Peptidase_M10 143..301 CDD:278824 80/168 (48%)
ZnMc_MMP 143..301 CDD:239805 80/168 (48%)
HX 513..707 CDD:238046 68/195 (35%)
Mmp25NP_001028511.1 PG_binding_1 89..140 CDD:279773 14/49 (29%)
Cysteine switch. /evidence=ECO:0000250 143..150 3/6 (50%)
Peptidase_M10 170..334 CDD:278824 80/167 (48%)
ZnMc_MMP 170..334 CDD:239805 80/167 (48%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 336..366 13/168 (8%)
HX 368..562 CDD:238046 68/195 (35%)
Hemopexin 1 368..417 21/48 (44%)
Hemopexin 2 421..466 13/45 (29%)
Hemopexin 3 467..515 19/48 (40%)
Hemopexin 4 516..562 11/45 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 547..582 2/16 (13%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 47 1.000 Domainoid score I11919
eggNOG 1 0.900 - - E1_KOG1565
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 370 1.000 Inparanoid score I2112
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1075463at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3504
SonicParanoid 1 1.000 - - X44
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
87.900

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