Protein Alignment Mmp2 and Mmp27

DIOPT Version :10

• Sequence 1: NP_995788.1
• Gene: Mmp2 / 35997
• FlyBaseID: FBgn0033438
• Length: 758
• Species: Drosophila melanogaster
• Sequence 2: NP_001297646.1
• Gene: Mmp27 / 234911
• MGIID: 3039232
• Length: 525
• Species: Mus musculus
• Alignment Length: 752
• Identity: 173/752 - (23%)
• Similarity: 265/752 - (35%)
• Gaps: 257/752 - (34%)

  Fly    10 LLALFAQSMCIQELSLPPEGSHSTAATRSKKAKTAISEDIMYNYLMQFDYLPKSDLETGALRTED 74
            ||:|....:.: ..:.||:          :|.|...:..:...||.||..|..........:...
Mouse    18 LLSLMVNFITL-SAAFPPD----------RKDKNEENNQLAQAYLNQFYSLEIEGSHFVQSKNRS 71

  Fly    75 QLKEAIRSLQSFGNITVTGEIDSATARLIQKPRCGVGDRRSADSFSPDNLYHEIGSNVRVRRFAL 139
            .....:|.:|:|..:||||::||.|..:::.|||||.|                     |.::..
Mouse    72 LFDGKLREMQAFFGLTVTGKLDSDTLAIMKVPRCGVPD---------------------VGQYGY 115

  Fly   140 QGPKWSRTDLTWSMVNRSMPD--ASKVERMVQTALDVWANHSKLTFREVYSDQADIQILFARRAH 202
            ..|.|.:..||:.::|.: ||  .:.|:..:|.||.||:..:.|||..:....|||.|.|....|
Mouse   116 TLPGWRKYSLTYRIMNYT-PDMTPADVDEAIQKALQVWSKVTPLTFTRISKGVADIMIAFRTGVH 179

  Fly   203 G-DGYKFDGPGQVLAHAFYPGEGRGGDAHFDADETWNFDGESDDSHGTNFLNVALHELGHSLGLA 266
            | ....||||..||.|||.||.|.|||.|||.||||    .:.|..|.|...||.||.||||||:
Mouse   180 GWCPRHFDGPLGVLGHAFPPGLGLGGDTHFDEDETW----IAKDGEGFNLFLVAAHEFGHSLGLS 240

  Fly   267 HSAIPDAVMFPWYQNNEVAG-NLPDDDRYGIQQLYGTKEKTWGPYKPQTTTTTTTTTTMRAMIYR 330
            ||....|:|||.|.:.:.:. .|..||..|||.:||:        .|:.||
Mouse   241 HSNDQTALMFPNYISLDPSKYPLSQDDIDGIQSIYGS--------PPKVTT-------------- 283

  Fly   331 ADKPAYWPWNNPSNNPNNDRNRARERQEEERRRQEKERRRQEEERRHQEEERRRQVEERQRQEEE 395
                                                                             
Mouse   284 ----------------------------------------------------------------- 283

  Fly   396 RWRQEQERQEEENRRRKIEHKSQWERNPSKERNRPRERQEMERRRQEQERQEQERQEQEDRRRER 460
                                                                             
Mouse   284 ----------------------------------------------------------------- 283

  Fly   461 ERDRQLEWERRNRNGAREPVTPTANTTPRPTNKPYPTVHRQHHHHNKPRKPKPDSCMTYYDAISI 525
                                .|:.|:.|...:   ||:                    .:|||:.
Mouse   284 --------------------KPSGNSEPHACD---PTL--------------------TFDAITT 305

  Fly   526 IRGELFIFRGPYLWRIGTSGLYNGYPTEIRRHWSALPENLTKVDAVYENKQRQIVFFIGREYYVF 590
            .|.|:..|:|.:|||: .|.:.......|...|.:||.:|   .|.||:.:.:::.|....::|.
Mouse   306 FRREVMFFKGRHLWRV-YSDIAGAEFEFIDSFWPSLPADL---QAAYESPRDELLVFKDENFWVI 366

  Fly   591 NSVMLAPGFPKPLASLGLPPTLTHIDASFVWGHNNR-TYMTSGTLYWRIDDYTGQVELDYP-RDM 653
            ....:.||:||.:.:||.|..:..|||: |..|:.| |:...|...||.|:....::..:| |.:
Mouse   367 RGYSVLPGYPKSIHTLGFPRRVKKIDAA-VCDHDTRKTFFFVGIWCWRYDEMAQAMDRGFPQRII 430

  Fly   654 SIWSGVGYNIDAAFQYLDGKTYFFKNLGYWEFNDDRMKVAHARAKLSARRWMQCARSANEVDDEQ 718
            ..:.|:...:||.||: :|..|||.....:|::   ||..:....:....|..|....|     .
Mouse   431 KCFPGIRLRVDAVFQH-NGFLYFFHGSRQFEYD---MKAKNITQVIKTNSWFLCNEPLN-----A 486

  Fly   719 RWTASLVSEGEETGRSGSRELRINHFILSILLLAIAN 755
            .:..|:..:....|     .:.::|..||:|..:|.:
Mouse   487 SFNVSVKGKANSIG-----TVILHHKRLSLLTFSIVH 518

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mmp2	NP_995788.1	PG_binding_1	52..103	CDD:460223	15/50 (30%)
		Peptidase_M10	143..301	CDD:425668	70/161 (43%)
		HX	513..707	CDD:238046	54/195 (28%)
Mmp27	NP_001297646.1	PG_binding_1	45..100	CDD:460223	15/54 (28%)
		Peptidase_M10	120..276	CDD:425668	70/160 (44%)
		HX	291..480	CDD:238046	57/220 (26%)