DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mmp2 and zmp-4

DIOPT Version :9

Sequence 1:	NP_995788.1	Gene:	Mmp2 / 35997	FlyBaseID:	FBgn0033438	Length:	758	Species:	Drosophila melanogaster
Sequence 2:	NP_506678.2	Gene:	zmp-4 / 179991	WormBaseID:	WBGene00012364	Length:	472	Species:	Caenorhabditis elegans

Alignment Length:	259	Identity:	60/259 - (23%)
Similarity:	103/259 - (39%)	Gaps:	40/259 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 YLMQFDYL---PKSDLETGALRTEDQLKEAIRSLQSFGNITVTGEIDSATARLIQKPRCGVGDRR 114
            ||.:|.|:   |..:::|....:|.|.|:|:...||......:|::|..|...:.:.||...|..
Worm    40 YLFKFGYMIPEPHQNVKTIQEPSEKQTKDALIRFQSAFLYYSSGDVDVPTQAKMNEWRCANNDMD 104

  Fly   115 SADSFSPDNLYHEIGSNVRVRRFALQGPKWSRTDLTWSMVNRSMPDA---SKVERMVQTALDVWA 176
            ......|                |.:...|::..||:.:||  .|:.   :::......|.:.|.
Worm   105 KGQPIPP----------------ASKKELWTKKSLTYKVVN--TPNTLSQAQIRSAAHEAFEQWT 151

  Fly   177 NHSKLTFREVYSDQADIQILFARRAHGDGYKFDGPGQVLAHAFYPGEGRGGDAHFDADETWNFDG 241
            ..|...|.|......||.|.|          :|.|...|..|....:........|.::.|.:
Worm   152 RASGFKFVETTGATPDITITF----------YDVPQSNLRIAGSASKPVNSHIILDKNQEWAY-- 204

  Fly   242 ESDDSHGTNFLNVALHELGHSLGLAHSAIPDAVMFPWYQ----NNEVAGNLPDDDRYGIQQLYG 301
            :|....|.:..:..|||:||.|||.|:....::|.|.::    .:.....:|:.||..|:::||
Worm   205 KSQAPMGISLYHTLLHEIGHILGLPHTFYRGSIMHPIFKPVLLPHGTVDTVPNVDRLAIRKIYG 268

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mmp2	NP_995788.1	Peptidase_M10	143..301	CDD:278824	38/164 (23%)
		ZnMc_MMP	143..301	CDD:239805	38/164 (23%)
		HX	513..707	CDD:238046
zmp-4	NP_506678.2	Peptidase_M10	118..268	CDD:334067	38/163 (23%)
zmp-4	NP_506678.2	HX	283..471	CDD:238046
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1565
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1075463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10201
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920