DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mmp2 and zmp-6

DIOPT Version :9

Sequence 1:	NP_995788.1	Gene:	Mmp2 / 35997	FlyBaseID:	FBgn0033438	Length:	758	Species:	Drosophila melanogaster
Sequence 2:	NP_498599.1	Gene:	zmp-6 / 176025	WormBaseID:	WBGene00020646	Length:	279	Species:	Caenorhabditis elegans

Alignment Length:	274	Identity:	78/274 - (28%)
Similarity:	119/274 - (43%)	Gaps:	60/274 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   114 RSADSFSPDNLYHEIGSNVRVRRFALQGPKWSRTDLTWSMVNRSM--PDASKVERMVQTALDVWA 176
            ::.|...|      ||...|.:|:.::..:|.:..|||.:..:::  ||...|...:..|.:.|:
Worm    25 KNLDFIKP------IGFGSREKRYVIRAKRWKKHTLTWQLQTQNLLDPDVFIVRNTMHRAFNEWS 83

  Fly   177 NHSKLTFREVYSD-----QADIQILFARRAHGDGYKFDGPGQVLAHAFYPGEGRGGDAHFDADET 236
            ..|.:.|||:..|     ..||.|.|.:..|.||:.|||...|:||||||.:||   .||||:|.
Worm    84 TVSSVDFREIPPDLVTKQPPDIYIAFEKGEHSDGFPFDGQDGVVAHAFYPRDGR---LHFDAEEQ 145

  Fly   237 WNFDGESDDSHGTNFLNVALHELGHSLGLAHSAIPDAVMFPWYQNNEVAGNLPDDDRYGIQQLY- 300
            |:.    :...|.|....|:||:||.|||.||....|.||...:..:.|..|.|||...|:.|:
Worm   146 WSL----NSVEGVNLFQTAVHEIGHLLGLEHSMDVRAAMFAAKRPYDPAFTLGDDDVRAIRSLFP 206

  Fly   301 ----------------------------GTKEKTWGPYKPQTTTTTTTTTTMRAMIYRADKPAYW 337
                                        |..|:...|:...:|||::::           ..:::
Worm   207 INETDANSGSEENSEDPVTTVKPISKEEGIDEENNDPFDASSTTTSSSS-----------PDSFF 260

  Fly   338 PWNNPSNNPNNDRN 351
            |:..||......||
Worm   261 PFPLPSIEHFQRRN 274

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mmp2	NP_995788.1	Peptidase_M10	143..301	CDD:278824	61/193 (32%)
		ZnMc_MMP	143..301	CDD:239805	61/193 (32%)
		HX	513..707	CDD:238046
zmp-6	NP_498599.1	ZnMc_MMP	48..205	CDD:239805	60/163 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1565
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1075463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10201
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3504
SonicParanoid	1	1.000	-	-		X44
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.950